Biomedical subjects

G Glezerson

Publications and source records attributed to G Glezerson.

6 recordsLinked to original sources

PubMed1993

The neuroendocrine cell population of the human prostate gland.

Neuroendocrine cells have been reported in up to 50% of all prostatic adenocarcinomas. These cells appear to influence the prognosis of these tumors. The distribution of the neuroendocrine cell population in the normal prostate gland, through all stages of development, has not been documented previously. We define the distribution of this cell population and describe 4 cellular morphological variants. The neuroendocrine cells of the peripheral zone appear to respond to factors present at birth and at puberty, while those of the periurethral glands and prostatic duct system are not influenced by this factor. It is postulated that this factor may be the levels of circulating androgens. The presence of at least 2 functionally distinct populations of neuroendocrine cells raises the possibility of 2 different embryonic origins. The study documents the distribution of calcitonin-producing cells but fails to detect the presence of somatostatin.

Adolescent↗

PubMed1992

Prostate-specific antigen and prostate-specific acid phosphatase in neuroendocrine cells of prostate cancer.

Prostate-specific antigen is a specific immunohistochemical marker of benign prostatic epithelium and prostate cancer. A subpopulation of neuroendocrine cells seen in 50% of cancers do not produce this protein marker. These cells appear to secrete prostate-specific acid phosphatase. This finding may explain the marked variation in serum prostate-specific antigen levels in all stages of prostate cancer.

Acid Phosphatase↗

PubMed1991

Neuro-endocrine cells--a new prognostic parameter in prostate cancer.

Neuro-endocrine cells are a recognised component of prostatic ducts and acini. Half of all clinically manifest cancers show neuro-endocrine differentiation. Occult carcinomas have a lower incidence of such differentiation. Neuro-endocrine cells are of major prognostic importance and appear more reliable in predicting patients' survival than do conventional histological grading systems.

Adenocarcinoma↗

PubMed1991

Crossed renal ectopia. Case report.

Crossed renal ectopia is a relatively rare anomaly with non-specific manifestations, sometimes diagnosed incidentally. Eight cases are reported, the etiology, diagnostic approach and management of the urological complications are discussed.

Adolescent↗

PubMed1990

Prostatic carcinoma: histological and immunohistological factors affecting prognosis.

Neuro-endocrine or paracrine cells of the human prostate and urethra have been identified by various methods, predominantly silver stains and immunocytochemistry. The incidence of neuro-endocrine differentiation in prostatic carcinoma has varied considerably from 10 to 100%, but has not been studied previously as an independent factor affecting prognosis. Nucleolar organiser regions (NORs) are loops of ribosomal RNA occurring in the nucleoli of cells which ultimately process RNA genes. NORs have been demonstrated by silver (Ag) staining techniques and have been studied in numerous malignant tumours. A pilot study from this laboratory has shown a distinct and significant difference in AgNOR staining between prostatic carcinoma and benign prostatic epithelial hyperplasia. A retrospective study was performed with at least 6 years' follow-up. This confirmed the presence of neuro-endocrine cells in more than half of the patients under investigation. A significant correlation between survival and the absence of neuro-endocrine cells was demonstrated. AgNOR staining was shown to be of no prognostic value.

Follow-Up Studies↗

PubMed1989

Post-traumatic parotid fistulae and sialoceles. A prospective study of conservative management in 51 cases.

The management of parotid sialoceles and fistulae have been unsatisfactory in the past, and numerous methods of treatment with varying success and morbidity have been described. The present prospective study reports results of conservative therapy in 51 patients over a 3-year period. In 50 patients, the injury healed upon conservative management. During the early phase of the study, a limited conservative regimen through which the patients received nothing orally for 5 days only was used. During the latter part of the study, patients were administered nothing orally until complete healing of the injury. In terms of the time it took for healing of the injury, the differences of the two regimens (24 +/- 4 vs. 9.4 +/- 0.9 days) was highly significant (p less than 0.001). The response to conservative management depended on the severity of injury as demonstrated by sialography. Injury to minor intraparotid ducts (G1) healed in significantly less time compared with that to a major intraparotid duct (G2) or ductal injuries (p less than 0.001). There was no difference between the healing of G2 injury (10.3 +/- 1.8 days) and partial ductal transections (10.5 +/- 2.2 days) (p greater than 0.05). There was a significantly greater delay in healing with complete duct transections (21.5 +/- 3.7 days) compared with partial duct transections and G2 injuries (10.2 +/- 2.1 days) (p less than 0.01). There was no difference in the mean period for healing between salivary fistulae and sialoceles (p greater than 0.05). It is concluded that a new classification of parotid fistulae based on sialographic findings has prognostic and therapeutic value. Furthermore, the excellent results achieved with conservative therapy in this study suggest that it may be the initial treatment of choice for parotid fistulae.

Acute Disease↗