[The treatment of snake bite injuries].
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Biomedical subjects
Publications and source records attributed to G Gmyrek.
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An approximation variant of the 1-compartment model and its clinical application in routine work are described. It is demonstrated how quantity and distribution of the dialyses, clearance and duration of the dialysis are to be chosen in order to obtain in a patient a course of the urea concentration striven for. A probable residual dialysis is taken into consideration. By this means an adaptation of the management of dialysis to the protein balance of the patient and to the effect of the dialysis with regard to easily dialysable substances is possible. The system demonstrated stood the test in clinical routine work. It is simple in its application, since the connections can be brought in easily legible graphs. Decisions in practice on duration of the dialysis, type of dialyzer and frequency of dialysis get a quantifiable basis.
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An equipment for the continuous recording of the oxygen consumption and other parameters in the awake rabbit is presented. Construction, function, advantages, and failings were described. More than 300 successful animal experiments were carried out by means of this equipment till now. It is characterized by a clear structure and a simple operation and has a stable function. Important indications are the course and the therapy of the shock, the energy transformation in the postoperative respectively the posttraumatic phase, and the influence of drugs on the metabolism.
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A technically simple method for the continuous recording of the arterial blood pressure in the conscious rabbit is described. For the placement of the catheter it is not necessary to perform a temporally expensive preparation. The median auricular artery of the animal can be used repeatedly above all. In case the arterial mean pressure is needful as a control mechanism then this method is recommended especially.
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Regional function parameters under myocardial ischemia are frequently clearly changed when the parameters as the stroke volume, cardiac output, ejection fraction and the like are still unchanged by a compensation mechanism. Length changes can be measured regionally and phasically by means of a mercury wire strain gauge. The active shortening during the ejection time in relation to the total length change in this region is a possibility for the registration of the relative systolic shortening (delta LS%). Changes will be quantified still clearer and earlier if in the x-y display a vector representation of the regional displacements with the pressure in the left ventricle takes place. The plane of this vector decreased already a few seconds after the coronary occlusion. This is therefore a special early change in ischemia. The important for the estimation of therapeutic measures and other indirect measuring methods is accentuated.
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The relatively rare complications developing under local anaesthesia may be due to various causes. The possibilities of the development of accidents under local anaesthesia are outlined; and prophylactic and therapeutic measures are deduced. A schematic premedication cannot prevent the development of complications with a sufficient degree of certainty; for instance, in certain cases the administration of atropine alone will still worsen the course of a complication. On the contrary, an individual premedication should be aimed at, especially in risk patients; the dosage must take into consideration all important factors. Consequently, atropine is of less importance than, for example, psychopharmaca and beta-receptor blockers.
The ventricle function can be established by the vectorial description of left-ventricular pressure parameters or flow sizes, respectively. The vector diagrammes result from the momentaneous pressure within the ventricle on the X-axis and the differentiated pressure curve or the aortic flow, respectively, on the Y-axis. Well surveyable from the vector loop received (LVP/dp/dt) are established dp/dtmax, dp/dtmin, LVPmax, LVEDP as well as the tg of the pressure increase speed or the pressure decrease speed, respectively, pro developed pressure. By way of example medicamentous changes of the vector diagrammes were induced and the parameters mentioned established. The vectorial demonstration of the left-ventricular haemodynamics seems to give additional informations concerning the phase of centraction and relaxation
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