[Prions and infantile pathology].
The authors briefly review the problem of prions pathology (with particular emphasis on children). The outstanding interest of the subject justifies this review.
Animals↗
Biomedical subjects
G Gomirato
Publications and source records attributed to G Gomirato.
Prion-induced neuro-psychiatric syndromes.
Although further research is needed, the most recent thinking is that prions are tiny protein particles without DNA or RNA which have the ability to infect humans or animals. Prions cause slow infections which are fatal, experimentally transmissible, evoke no immune resistance from the infected host and are more resistant to disinfectants and chemical or physical agents than the other micro-organisms that proliferate in the infected host. Update no evidence of possible passage by mouth from cows to men with consequent illness.
Animals↗
[On the diagnosis of so-called "constitutional" bone diseases].
The authors review the diagnosis process of so-called "constitutional" bone diseases. They criticize the nomenclature and international classification of them and suggest a diagnostic classification which is virtually independent of structural and metabolic criteria: based on the site and extent of pathological manifestations. The paper also examines the term "dysmorphia", given that it is the shape of the bone segment which initially attracts and guides the clinical diagnosis of embryonal osteochondropathies and suggest it.
Body Constitution↗
The diagnosis of so-called "constitutional" bone dysmorphias (embryonal osteochondropathies).
The authors review the diagnosis of so-called "consitutional" bone diseases. They criticise the international nomenclature and classification of the latter and propose a diagnostic classification for embryonal osteochondropathies, which is virtually independent of the structural and metabolic criteria, based on the criterion of site and the extent of pathological manifestations. They also examine the term "dysmorphia" given that it is the shape of the bone segment which first attracts attention and guides the clinical diagnosis of embryonal osteochrondropathies.
Bone Diseases↗
[Cytokines, immunostimulation and lactic enzymes].
On the basis of numerous experimental studies the authors advance the hypothesis of the use of lactoferments for immunomodulating purposes. This entails using a traditional and innocuous method for infantile prophylaxis and therapy, (adapted for immunodepressive and even iatrogenic syndromes) which might be assigned a new role through modern, large-scale experimental research.
Age Factors↗
[Low cholesterol and pathological manifestations].
The paper reviews the literature on the association between hypocholesterolemia and various pathologies. There are few studies on this topic and these are often fragmented and uncertain, in particular with regard to children. However, studies with a wide statistical basis have focused on the different stages of adulthood. There does not appear to be a genuine link between "low cholesterol" and disease in childhood, although the contrary would appear to be true. The authors invite pediatricians to examine this aspect further in view of the major repercussions that it may have on a wide range of factors. For this reason the authors consider it worthwhile presenting this innovative topic and field of research.
Cholesterol↗
Some objections to the international nomenclature for constitutional diseases of the bone.
The International Nomenclature of Constitutional Diseases of Bone is criticised and the concept of embryonic osteochondropathy is proposed as an alternative approach. It is claimed for example that the term "constitutional" has no real scientific or, above all, medical meaning. The defects of this "official" nomenclature are highlighted and a slimmer classification system of use in the diagnosis of osteochondroblastic mesenchymopathies is recommended.
Bone Diseases, Developmental↗
Criticism of the International Nomenclature of Constitutional Diseases of Bone.
The International Nomenclature of Constitutional Diseases of Bone is criticised and the concept of embryonic osteochondropathy is proposed as an alternative approach. It is claimed for example that the term "constitutional" has no real scientific or, above all, medical meaning. The defects of this "official" nomenclature are highlighted and a slimmer classification system of use in the diagnosis of osteochondroblastic mesenchymopathies is recommended.
Bone Diseases, Developmental↗
[Relationship between the immune system and the neuroendocrine system in childhood].
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Age Factors↗
[The atherosclerosis problem in infancy. Some considerations].
The problem of some aspects of infantile atherosclerosis is examined synthetically (period of onset, classification of hyperdyslipidemia, lipidic fractions, threshold values, variations with age) and prevention examined at length. In particular, stress is laid on a "mixed" mass screening method to prevent many subjects being untouched by targeted screening investigation.
Arteriosclerosis↗
[Diagnostic considerations in "constitutional bone diseases"].
The author makes a few diagnostic comments regarding the so-called constitutional bone diseases, quoting the international nomenclature and a classification which is thought to be useful for diagnosis, based on clinical and radiological criteria rather than purely structural and metabolic findings.
Bone Diseases, Developmental↗
[A case of familial bilateral polycystic kidney].
The paper describes a case of bilateral polycystic kidney in a 14-year-old whose father and 3 brothers are also affected by bilateral renal cystic dysplasia (as is a paternal aunt), while a paternal uncle is affected by constant hematuria with no ultrasound signs of renal cystic dysplasia. The case in question is an adult type of dominant autosomal polycystic renal dysplasia, affecting all the males in the family and also a female within the family nucleus. The case is described in the light of the most recent reports on the subject and the problem of prevention is also discussed.
Adolescent↗
[Remarks on a clinical case of partial carbamyl phosphate synthetase deficiency].
A preliminary undiagnosed case of partial carbamyl-phosphate-synthetase deficiency in a 14 year old patient is described. This extremely rare metabolic disorder is unlikely to produce clinical symptoms at such an advanced age. Details are given of the clinical picture, the diagnosis (by liver biopsy and post mortem liver examination) and the attempts at treatment.
Adolescent↗
[Bronchopneumopathies in children. Diagnostic criteria].
After reviewing the incidence and aetiology of the lower respiratory infections found among children, the problem of diagnosis is tackled in relation to phenomenology and laboratory contributions before a detailed examination of diagnostic radiology. It is emphasised that diagnosis, which has a direct influence on choice of treatment, is essentially based on epidemiological and clinical data for which radiological findings merely constitute a back-up, however valuable, except in special cases.
Bacterial Infections↗
[Effect of cimetropium bromide in the treatment of colic in the first 3 months of life. Randomized study].
UNLABELLED: 20% of unweaned children aged below three months suffer from so-called gaseous colic. The effectiveness and tolerance of an antimuscarinic drug with high spasmolytic activity on the smooth visceral musculature, cimetropium bromide, has been evaluated, excluding cases of intolerance to cow's milk and other pathologies. 40 random patients of both sexes of average age 4.4 weeks (symptoms lasting for one week with crying fits lasting for more than 90 minutes consecutively, on at least 3 days a week) split into two groups of 20 patients each were studied. TREATMENT: A) 1.2 mg/kg 1 hour before bottle; B) 2.0 mg/kg 1 hour before bottle. Speedy reduction in the number of crying episodes (Group A: from 2.8 +/- 0.3 to 0.1 +/- 0.1; Group B: from 2.8 +/- 0.4 to 0.6 +/- 0.4; differences n.s.) and in their duration (Group A: 99 min +/- 10 min to 5 min +/- 3 min; Group B: from 121 min +/- 11 min to 15 min +/- 9 min; differences n.s.). The pharmacological treatment was considered: Group A: very good in 75% of cases; Group B: very good in 70% of cases. In Group B 4 episodes of stypsis occurred and these resolved immediately upon suspension of the drug. Given the equal effectiveness and better tolerance, the use of cimetropium bromide is recommended at the lower dosage.
Colic↗
[A case of Beckwith-Wiedemann syndrome].
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Beckwith-Wiedemann Syndrome↗
[Early feeding of the newborn infant: a retrospective evaluation of 3 alternative patterns].
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Animals↗
Experimental pharmacological Parkinsonism (preliminary report).
The purpose of our project was to analyse membrane-bound proteins in Haloperidol-treated rats with clear Parkinson type motor inhibitions. Membrane-bound protein was chosen because the main sites of functional changes in the Parkinson syndrome may be the plasma membrane and postsynaptic membranes of nerve cells. Twenty male Sprague-Dawley rats were treated with Haloperidol for 67 days. The areas analyzed were the hippocampus and the caudate nucleus. The electrophoretic analyses were done by the method of Ballou (1974) as further elaborated by Booth (1977). Double-labeling analysis of 7 protein fractions after gel electrophoresis showed the presence of a 50 000-dalton protein in fraction 3 of the caudate nucleus (see block diagrams) in the haloperidol-treated animals but not in the hippocampus material.
Animals↗