PubMed Health⌕ Search

Biomedical subjects

G Gonda

Publications and source records attributed to G Gonda.

At least 19 recordsLinked to original sources
PubMed2002

Esophageal intramural metastasis from adenocarcinoma of the gastroesophageal junction.

Among a total of 143 patients examined for diagnosis of adenocarcinoma of the cardia, intramural esophageal metastases were verified in six patients (4.19 %). In each case the diagnosis was confirmed by histological examination. The histological structure of the primary tumors and metastases was the same. Metastases were detected by endoscopic ultrasound examination in three cases. All the cardia tumors proved to be well advanced. As well as endoscopic identification of the primary tumor, thorough examination of the proximal part of the esophagus is of great importance.

Adenocarcinoma↗
PubMed2001

[Siewert-Stein classification of adenocarcinoma of the esophagogastric junction].

Nowadays the terminology used for the definition of adenocarcinomas at the oesophagogastric junction is "cardiac carcinoma", which can be easily misunderstood. This definition of adenocarcinomas of the oesophagogastric junction does not allow correct comparison of diagnosis (endoscopic, radiological and pathologic), epidemiology and surgical therapy in national and international aspects, because different tumours can develope in the same area, and all called cardia tumors. Siewert and Stein recommended a classification to solve this problem. The classification of the tumours is morphological/topographical. Type I is adenocarcinoma of the distal part of the oesophagus. Type II is adenocarcinoma of the real cardia and type III is subcardial gastric adenocarcinoma. At classification, we always consider results of endoscopy (ortograde and retroflexed view of the oesophago-gastric junction), the x-rays of the oesophagus and stomach, findings at the operation and pathohistologic results. Between 1/1/1974 and 31/12/2000, a total number of 50,878 upper panendoscopic examinations were performed at the Endoscopic Laboratory of the Surgical Department. Adenocarcinoma of the cardia was diagnosed in 488 patients. According to the Siewert-Stein classification, type I tumour was found in 123 (25.2%), type II in 240 (49.18%), and type III was present in 125 (25.61%) patients. The importance of this classification is it enables unified pre-operative assessment and it can also help to decide the type of the surgical intervention. In our patients with type I cancer--depending of the size of the tumour--distal 2/3 oesophagectomy with the resection of the proximal lesser curve of the stomach or total gastrectomy were performed. In the first group oesophago-jejuno-gastrostomy, in case of total gastrectomy Roux-en-Y loop anastomosis was created. In patients with types II and III cancers total gastrectomy was performed. In every patient lymphadenectomy was performed. We suggest the use of this new classification in clinical, gastroenterology--with special regard to the endoscopy--and pathology.

Adenocarcinoma↗
PubMed2001

[Rare late complication after subtotal esophagectomy].

We report a case of a peptic ulcer developed in the stomach tube used for the replacement of the esophagus. The patient was a 60 years old female who had undergone subtotal esophagectomy for mid esophageal malignancy, with intrapleural stomach replacement. Urgent endoscopy revealed an excavated, bleeding ulcer in the thoracic part of the stomach. After unsuccessful medical treatment urgent operation was performed via right thoracotomy. Opening the stomach an ulcer was found on the posterior wall of the stomach, it was penetrating to the right atrium of the heart. The bleeding was controlled by suturing the atrium wall. The patient treated with i.v. Omeprazol in the postoperative period. On the 21st postoperative day a rebleeding occurred causing shock. After reoperation the patient died. This complication is very rare. We emphasise the importance of postoperative pH measurement investigations showing the presence of duodenogastric reflux disease.

Esophagectomy↗
PubMed2001

[Esophageal implantation metastasis from adenocarcinoma of the cardia].

A 74 years old male patient was admitted to our department suffering from dysphagia for five months. Gastric Barium studies showed a cardia tumour with polypoid lesions in the wall of the esophagus, and gastro-esophageal reflux disease was also diagnosed. Endoscopy verified a cardia tumour with esophageal metastasis, and biopsy was obtained from the two lesions. Histology showed that both tumours were adenocarcinomas. Endoscopic ultrasonography classified the cardia tumour as grade T2. As observed during endoscopy, the wall of the esophagus at the level of the polypoid lesion was hypo-echogenic and thick which was result of thickened mucosa. Total gastrectomy and oesophagectomy was performed. Pathology showed that the cardia tumour was pT2N2 and type Siewert-Stein II. The esophageal polypoid lesion was also proved an adenocarcinoma, which was localized only to the mucosa. No tumour cells were found in the blood- or in lymph vessels between the tumour and the esophageal adenocarcinoma. We think that the polypoid adenocarcinoma in the esophagus is an esophageal metastasis implantation from the cardia adenocarcinoma. It is based on the exclusion of other possible tumour dissemination routes. Probably the gastro-esophageal reflux is responsible for the implantation of tumour cells.

Adenocarcinoma↗
PubMed2000

[Regression of gastric MALT lymphoma after eradication of Helicobacter pylori infection followed by endoscopic ultrasound].

The authors report a case of a 42 year-old female patient, who was admitted with epigastric pain and weight loss to our department. Upper gastrointestinal endoscopy two ulcerated lesions revealed in the stomach at the corpus-antrum border. Histologically the lesion proved to be a low grade, malignant B cell MALT lymphoma. Coexistent Helicobacter pylori infection was detected with modified Giemsa staining. Endoscopic ultrasonography was performed to determine the depth of tumorous infiltration of the gastric wall: the tumor was confined to the mucosa and submucosa. No regional lymph node was observed. As a result of successful Helicobacter pylori eradication the regression of MALT lymphoma occurred. The follow-up examinations showed the regression of the tumour and the patient became asymptomatic. A control ultrasonographic examinations demonstrated the normal five layers structure of the gastric wall without any alteration. In our patient Helicobacter pylori eradication was an effective therapy for gastric MALT lymphoma as well. Our results similar as are published in the literature. Endoscopic ultrasonography is very useful in the assessment of the tumours involvement of the gastric wall. In the proper follow-up examinations of the patient endoscopy, histology and endoscopic ultrasound together are the methods to apply including Helicobacter pylori control.

Adult↗
PubMed1999

[Ganglioneuroma of the adrenal gland].

149 patients with adrenal incidentalomas were examined. Sixty-eight cases were histologically confirmed, five of them had ganglioneuromas. On the basis of these patients history current knowledge of this benign tumour was summarized. Histological and pathological characteristics of one tumour suggest that ganglioneuromas may develop by maturing of malignant neuroblastic tumours. The clinical symptoms (abdominal pain, meteorism) were local. In 2 of 5 cases mildly elevated levels of urinary vanillylmandelic acid and catecholamine could be measured. One patient had persisting hypertension after surgery. In an other patient previous diarrhoea stopped after the removal of tumour. On the basis of ultrasound and computertomographic features, the size and origin of a tumour and its relation to the surrounding organs can be well characterized. One patient was inoperable because of an infiltratively spreading tumour, but during five years of follow-up no tumour progression could be observed with computertomography. After surgery we could follow only 2 of 4 patients. Until now no recurrence of tumour were detected.

Adolescent↗
PubMed1999

Pituitary adenylate cyclase activating polypeptide (PACAP) is present in human and cat gastric glands.

In the present work we have studied the occurrence of pituitary adenylate cyclase activating polypeptide (PACAP) in human and cat stomach mucosa using immunohistochemistry. As seen under a light microscope, there were many large rounded and ovoid cells that were PACAP immunopositive, mainly in the neck of the gastric glands of both species. The immunopositive material was predominant in the perinuclear area. The PACAP immunolabeling was specific because the preincubation of the antiserum with PACAP abolished the immunostaining. In human samples under electron microscope, the PACAP immunoreactive cells have shown the characteristics of parietal cells. In faintly stained cells, the localization of DAB reaction product was associated with the surface of the intracellular canaliculi. Cell labeling could not be observed besides parietal cells.

Animals↗
PubMed1995

[Pulmonary echinococcosis].

Two patients with pulmonal Echinococcosis are presented by the authors. Contact with cestoda carrier animals cannot be revealed. At the first patient, who was without any complaints, the two round shadows in her chest X-ray were detected accidentally by screening examination and before the operation only eosinophilia, many eosinophil granulocytes in the pleural effusion and the positive complement binding reaction were related to the Echinococcosis, which was proved by the histological examination of the intraoperative biopsy. The other patient had complaints during months. In this case the Echinococcus granulosus broke into the bronchus and emptied in the sputum. Postoperative histological diagnosis can be obtained by help of the excision from the intraluminal alteration which was visible during bronchoscopy. The authors summarize the etiology, the clinical signs, the diagnose and the therapy of Echinococcosis. They call attention to the incidence of this mainly tropical disease in Hungary and to the rare soliter pulmonal manifestation of the Echinococcosis.

Adult↗
PubMed1994

The value of ultrasound in preoperative assessment of the myometrial and cervical invasion in endometrial carcinoma.

This study was undertaken to determine the accuracy of ultrasonography in depicting the depth of myometrial invasion and cervical involvement in women with adenocarcinoma of the endometrium. During the past 2 years, pelvic ultrasound using abdominal and vaginal probes was carried out as part of routine preoperative work-up in 69 consecutive patients with carcinoma of the endometrium. Fifty-eight patients were primarily operated on; the remaining 11 had preoperative intracavitary irradiation followed by surgery at the referral hospital. All patients underwent total abdominal hysterectomy with bilateral salpingo-oophorectomy and staging laparotomy. A Hitachi EUB 450 ultrasound machine with a high-resolution 6.5-MHz transvaginal transducer was used to assess the intrauterine extension of the tumor. Myometrial extension was measured from the endometrial-myometrial interface to the deepest edge of the tumor extension into the myometrium and was categorized as 0%, < 50%, or > 50% myometrial invasion. Cervical involvement was determined based on irregular echogenicity of the tumor in the cervix of the uterus. Sixty-three of 69 patients had no cervical involvement on ultrasound, whereas the cervix was negative in 60 subjects on pathological examination; i.e., there were 3 false-negative and no false-positive results. The correlation was highly significant (P < 0.001). Of these, the endocervix was involved in 5 cases (stage IIa) and there were 4 patients with stage IIb disease. All 3 false-negative cases were stage IIa, with microscopical involvement in 2 patients. In the third case histology demonstrated disease extending low to the inner cervical os and was considered involvement of the cervix. The inner half of myometrium was involved in 28 patients and the outer half in 31, and there was no myometrial invasion in 10 cases. The corresponding values for ultrasound were 29, 31, and 9, respectively; i.e., there was only 1 false-positive and no false-negative results. The correlation is highly significant (P < 0.001). Sonography revealed irregular interface between the endometrium and myometrium, giving the appearance of measurable myometrial involvement in the only woman with a false-positive result. Our results indicate that transvaginal sonography correctly predicts endometrial and cervical involvement in endometrial carcinoma. In evaluating these factors, ultrasound using transvaginal probes is probably more accurate than intraoperative gross evaluation or frozen section analysis. Preoperative knowledge of these variables allows the gynecologists an appropriate consultation in terms of extended surgery and to select those patients who might benefit from referral to gynecologic oncology centers.

Adenocarcinoma↗
PubMed1992

[Solitary plasmacytoma of the lung].

A case of solitary plasmacytoma of the lung in a 64 year old woman is reported. The anatomical and clinical features of this exceedingly rare form are discussed. Stress is laid on the 'fact that diagnostic certainty can only be obtained by immunohistochemistry. It is also necessary that patients be subjected to periodical radiological and immunological studies in the postoperative period to detect the possible occurrence of multiple myeloma.

Female↗
PubMed1978

Apparent movement, eye movements and phoria when two eyes alternate in viewing a stimulus.

Three experiments were conducted to test the hypothesis that the apparent movement of a stimulus when the two eyes are alternately occluded can be explained by phoria and Hering's principles of visual direction. In experiments 1 and 2, the direction of apparent movement, eye position, and eye movements were measured when eye movements did and did not occur. In experiment 3, the magnitude of apparent movement and the extent of phoria were comapred. Results from the experiments 1 and 2 indicated that the direction of apparent movement could be predicted from the direction of phoria, in conjunction with Hering's principles, and was not contingent on eye movements. In experiment 3, a high positive correlation (r = 0.95) between the magnitude of apparent movement and the extent of phoria was obtained.

Eye Movements↗