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Biomedical subjects

G Grümmer

Publications and source records attributed to G Grümmer.

9 recordsLinked to original sources
PubMed1996

Electrophoretic fingerprinting and multiparameter analysis of cells and particles.

A recently developed electrophoretic instrumentation based on a real-time image processing system has been applied to electrophoretic fingerprinting and multiparameter analysis of cells and other particles. The comparison between theoretical and experimental electrophoretic fingerprints, completed by the analysis of differences between measured fingerprints, offers a new methodology for better understanding and controlling of the processes at solid/liquid interfaces. Moreover, the multi-parameter analysis including electrophoretic mobility, size, density and shape of cells can complete the diagnosis and prognosis of diseases.

Ascitic Fluid↗
PubMed1995

New methods for the investigation of blood-biomaterial interaction.

Quantitative microscopy with integrated image processing is a useful tool for investigation of the interaction of blood components with biomaterials. We have developed new automated measuring devices suitable for simultaneously characterizing biological cells (size, shape, localization, migration, electrophoresis), synthetic particles (electrophoretic fingerprinting), and dialysis membranes (morphology, electric charge). These techniques are useful for the investigation of cell adherence on biomaterials, localization of cells in membrane filters (Chemotaxis), characterization of the protein adsorption on model systems, detection of cytokines (produced after lymphocyte-biomaterial contact), and estimation of morphological properties and charge distribution in dialysis membranes.

Biocompatible Materials↗
PubMed1994

Electrophoretic mobility profiles: new aspects of characterization and discrimination of biological surfaces.

An advanced method of measuring and analyzing electrophoretic mobility profiles (electrophoretic fingerprints) was developed and for the first time applied to the cell surface. Dissociation constants calculated from a suitable mathematical model describe dissociation and, in part, adsorption processes on the surface and can thus be used for the characterization of complex processes on biological surfaces and the evaluation of small differences between cell surfaces.

Adsorption↗