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Biomedical subjects

G Grünberg

Publications and source records attributed to G Grünberg.

At least 19 recordsLinked to original sources

[Sudeck's bone atrophy after leg phlebography - a case study of an unusual complication (author's transl)].

In a 39-year old man, a painful oedema had formed at the back of the foot perimalleolary one day after paravasal contrast medium injection following ascending phlebography. 8 weeks later, the x-ray film showed a maculate Sudeck's bone atrophy in the region of the toes, ankles and the heel. Sudeck's bone atrophy had obviously developed on account of a specific vegetative reactivity, subsequent to the local inflammation.

Adult↗

[The surgically treated aortic valve defect in the pre- and postoperative x-ray].

Within a postoperative control study of 81 patients with aortic valvular disease 14 patients showed cardiomegaly. This might be caused by several reasons as insufficiency of valvular prosthesis, coronary disease, adipositas or wrong digitalis application. All patients with pulmonary congestion, except one, showed a complete removal of congestion, because the wide position of the vessels was not yet fixed.

Adult↗

[The value of xerotomography of the lung and mediastinum in routine diagnosis (author's transl)].

Using controlled case material (n = 55), the weighted value of xerotomography is compared with that of conventional film tomography for the examination of mediastinum and lung. The validity of information of both methods for the final diagnosis is compared. In the visualisation of bronchial units and vascular structures, xerotomography is slightly superior to tomography with silver halogenide films, due to high degree of sharpness of detail, great object range and amplification of the marginal areas. Nodular hilar processes which are in spatial relationship to plane, pulmonary infiltrations or are overshadowed by the cardiac shadow, can be better clarified via conventional technique because of the differences in film density. Overshadowing of linear structures can simulate calcifications in the xeroradiographic image. In our opinion, a combination of film tomography in two planes with xerotomography in an optimal sectional plane can be recommended as a suitable procedure.

Bronchi↗

[The radiographic appearances following correction of left-to-right shunts (author's transl)].

Amongst 22 patients with corrected left-to-right shunts, a diminution in heart size and reduction in central pulmonary arteries and pulmonary plethora was found in about half the patients. A good operative result can be expected, particularly in younger patients with less severe lesions, where the vessels had not been subjected to a high pressure for a long period. The failure of vessels to return to normal is assurmed to be due to changes in the vessel walls. Possible causes for persistent cardiomegaly are, in addition to persistent shunts, coronary artery disease, obesity, inadequate digitalisation and aortic and mitral insufficiency.

Adult↗

[Fibrinolytic therapy in deep venous thrombosis of the upper and lower extremity].

Fibrinolytic therapy was carried out in 59 patients suffering from a total of 60 deep venous thromboses of the iliac segment (n = 24), the femoropopliteal segment (n = 18), the deep calf veins (n = 2), or the subclavian vein (n = 16). 46 patients received streptokinase (SK), 4 were given urokinase (UK), and 10 were treated with streptokinase followed by urokinase (SK + UK). The duration of fibrinolytic therapy was between 19 and 596 hours (x = 166 +/- 111 hrs). Phlebographic examination was used to determine the location of the thrombotic occlusion as well as to evaluate therapeutic results. To assure sufficient anticoagulatory protection during therapy with streptokinase the dose of streptokinase was either reduced by steps of 20,000 U/hr to a minimum of 40,000 U/hr or heparin was added as a continuous infusion. Urokinase was administered with a mean loading dose of 75,000 IU followed by an average maintenance dose of 40,000 IU/hr; it was always given in combination with heparin. When therapeutic success was graded as complete/partial/no recanalisation, the following results were obtained: thrombotic occlusion up to 1 week old 35%/48%/17%; up to 2 weeks old 57%/14%/29%; 3 or 4 weeks old 12%/38%/50%; older than 4 weeks 13%/37%/50%. The two most common side effects were a fall of the hemoglobin and a rise of body temperature. Treatment with SK had to be interrupted for bleeding in two cases. One patient diet after rupture of the liver and of the spleen following development of subcapsular hematoma in these organs, 3 patients survived pulmonary embolism without major long-term impairment. Considering medical and social aspects (preservation of capability for working in young adults) it appears justified to administer fibrinolytic agents up to a thrombus age of 14 days, in some cases even up to a thrombus age of 28 days. Good results in cases of deep vein thrombosis of the lower limbs are often obtained only when fibrinolytic therapy is extended beyond 96 hours. It should be performed in intensive care units only. Follow-up examinations of the venous drainage capacity up to 2 years after fibrinolytic therapy document the good therapeutic effect that is warrented by streptokinase or urokinase induced complete recanalisation.

Adolescent↗

[Combined carotid and femoral angiography in arterial occlusive disease (author's transl)].

"Asymptomatic" carotid stenosis with a murmur is an indication for carotid angiography, particularly in patients with peripheral arterial occlusive disease. Carotid angiography in the neck, carried out in two planes, makes it possible to differentiate different types of stenosis. Plaques and ulcerating strictures are a source of micro-emboli. The extent and localisation of extracranial carotid stenoses must be precisely defined because of their haemodynamic effects, particularly before major vascular surgery, which may result in a transient fall in blood pressure. Carotid angiography can be combined with femoral angiography in patients with peripheral arterial occlusive disease. In our experience, the combined angiography does not result in any increase in the complication rate. This experience is based on 38 patients seen in the last 14 months.

Angiography↗

[The value of xero-radiography of the breast following mammoplasty with silicone prostheses (author's transl)].

The well known advantages of xero-radiography make this particularly suitable for the evaluation of silicone prostheses which were implanted either after a subcutaneous mastectomy or during plastic surgery. Xero-radiography is valuable for demonstrating the soft tissues behind NaCl and Makrodex prostheses and is therefore particularly suitable when searching for tumours in these patients. In addition, it allows one to judge the cosmetic results, such as thickness and shape of the soft tissues, contours and wrinkling of the prostheses.

Breast↗

[Magnification technique in peripheral angiography (author's transl)].

Fourteen exactly similar conventional and magnified serial angiograms were compared and the advantages and disadvantages of magnification angiography are discussed. Particular attention was paid to exact comparability of the series in order to make the analysis valid. In three patients small end-vessels and collaterals were visible on the magnification angiogram which could not be seen on the ordinary series even in retrospect. Macro-angiography was also valuable in cases of microsurgery, both before and after operation. Considering the well-known disadvantages of magnification angiography, such as increased radiation and cost, its use appears to be indicated only for the elucidation of special problems.

Angiography↗

[Experience with percutaneous embolization of renal tumours (author's transl)].

We have repeated first observations of various authors of blocking angiography in 8 patients with renal tumours. Comparing angiographic findings and the surgical specimens, the success of embolization could be assessed. Control angiography 2 months following an inoperable renal tumor showed shrinking of the tumour by about one half and improvement of the general condition of the patient.

Adenocarcinoma↗

[Late diagnosis of thrombosis of the pelvic, femoral or calf veins (author's transl)].

The time interval which elapses from the occurrence to the diagnosis of thrombosis of the pelvic, femoral or calf veins was investigated in a retrospective study. As could be shown from the histories of 66 patients with phlebographically documented localization and extent of the thrombosis, in 85% of the cases the correct diagnosis was only made past the 7th day following the presumptive beginning of the thrombotic process, i.e. at a time when the period optimal for a fibrinolytic or surgical treatment had already passed. J-fibronogen-method in patients with an increased risk for thrombotic complications is recommended.

Diagnostic Errors↗

[Contra-lateral selective hip angiography (author's transl)].

A new method for the selective demonstration of the larger and smaller vessels which supply the hip is described. A curved catheter is introduced into the opposite femoral artery, it is advanced into the common iliac artery and a guide wire is then introduced into the femoral artery on the side to be examined. The catheter is withdrawn and a second, soft, catheter is introduced over the remaining guide into the femoral artery. The appropriate vessels can then be selectively catheterized by means of the catheter and guide wire. Good selective demonstration was achieved in 14 patients with various types of hip disease.

Angiography↗

A new method for producing a chronic E. coli pyelonephritis in rabbits.

Chronic pyelonephritis, especially that caused by the most common invader E. coli, corresponding satisfactorily to the pathophysiology of the human disease is difficult to reproduce. We have developed a pattern of infection with which we succeeded reliably in producing a chronic E. coli pyelonephritis. This was achieved by inserting a plastic catheter into the renal pelvis. A suspension of E. coli was injected via the catheter into the renal pelvis of 32 rabbits. This pattern of infection takes a chronic progressive course and, in all cases, results in typical macroscopic and histological changes in the kidney. The bacterial excretion in the urine remains unchanged over a period of months. With the experimental procedure described, the pathogenesis and pathophysiology of chronic E. coli pyelonephritis can be clearly studied. Drugs currently used on patients can be tested for their effectiveness in long-term application.

Animals↗

[Pancreaticography and its correlation with angiography and ultrasonography in diagnosis of the pancreas (author's transl)].

The endoscopic retrograde pancreaticography demonstrates - when suspecting "pancreas anulare" - the part of the pancreatic duct system that forms a ring around the duodenum, helping to recognize this anomaly. In chronic pancreatitis deformities of the pancreatic ducts may be visualized 2-3 years after the onset of the disease. There are deformities of the outlining and the course of the ducts as well as solitary and multiple stenosis and -most important- dilatation of the main duct and its branches. In pancreas abscess, necrotic cavities, and pseudocysts the retograde pancreaticography visualizes solitary or multiple perforations of the duct and pooling of contrast medium in cavities. Carcinoma of the pancreas presents stenosis, occlusion and deviation of the main duct and its branches and sometimes with lakes of contrast medium in ares of necrosis. Pancreaticography following trauma demonstrates similar to chronic pancreatitis laking of contrast medium following perforation. The endoscopic retrograde pancreatico-cholangiography has - like angiography and ultrasound - its special indications in diagnosis of the pancreas. They are important in cases which have affected primarily or secondarily the duct system. Its reliability in confirming and differentiating a disease increases with more accurate indication. In this journal in 1965 a critical review of roentgenologic examinations of the pancreas presumed that development of a valid preoperative pancreaticography would lead to priority of this method. This priority has become true in chronic pancreatitis, calculous pancreatitis and visualization of necrotic cavities. In those examples the endoscopic retrograde pancreatico-cholangiography is still not dominating all cases.

Angiography↗