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Biomedical subjects

G Granditsch

Publications and source records attributed to G Granditsch.

At least 37 records · Page 2Linked to original sources
PubMed1986

[Failure to thrive as a main symptom of intracranial tumors in early childhood].

In the course of only three years we studied three children, who presented for a long time with failure to thrive as the only symptom of an intracranial tumour. Up to 24 months elapsed from the first manifestation at the age of four, ten and eleven months to the final diagnosis. A suprasellar tumour was discovered once, an infratentorial one twice. In spite of lower caloric intake a more rapid weight gain was documented after neurosurgery. The intracranial tumour is an important part of differential diagnosis in infants and young children not thriving satisfactorily.

Astrocytoma↗
PubMed1985

Toxic epidermal necrolysis due to antiepileptic therapy in an 8-year-old boy.

Toxic epidermal necrolysis (TEN) has rarely been documented in children. We treated an 8-year-old boy who developed generalized blistering dermatosis after anticonvulsive therapy with diphenylhydantoin. The diagnosis was proved by exfoliative cytology, histology, and electron microscopy. The disease entity and its differentiation from staphylococcal scalded-skin syndrome and toxic shock syndrome are reviewed.

Adult↗
PubMed1985

[Allergic alveolitis in cow milk allergy].

The case history of a 12 months old boy with recurrent pneumonia following ingestion of cow's milk is described. After receiving cow's milk containing formula he presented with fever, tachypnea, diffuse rales and crepitations over both lungs. The chest X-ray revealed marked bilateral alveolar shadows. A high titer of antibodies against the four major antigenic components of cow's milk protein was demonstrated by Ouchterlony's precipitation test and the fluorescent immunosorbent test. Withdrawal of cow's milk from the diet resulted in complete resolution of clinical and radiological findings.

Alveolitis, Extrinsic Allergic↗
PubMed1984

[Use of double-contrast examination of the small intestine in children].

Results of 28 double-contrast examinations of the small intestine in 19 children are described together with the technique employed. Pathological findings are seen in children with Crohn's disease. The radiological criteria of the healthy small intestine and the findings in case of Crohn's disease are described. This method should be used in children with suspicion of a morphological disease of the small intestine, especially in Crohn's disease, for first diagnosis and for follow-up, since it enables accurate interpretation of the findings. The double-contrast technique can help to largely avoid false-positive and false-negative x-ray findings. This justifies the relatively high effort.

Adolescent↗
PubMed1981

Exposure to X-rays during small bowel biopsies in children.

Peroral small bowel biopsy is a decisive step in the diagnosis of coeliac disease and is performed frequently. The patient's exposure to ionizing radiation during fluoroscopic control therefore deserves consideration. Compared to data in the literature, the biopsy method employed at the University Children's Hospital in Vienna achieves a markedly shorter duration of fluoroscopy. These values were registered during 1039 biopsies. In 439 examinations the exposure area products were also documented In 10 consecutive biopsies additional measurements were carried out by lithium fluoride thermoluminescence dosimeters attached to the patient. Expert biopsy-technique with precise and thoughtful use of modern fluoroscopes on the one hand, and critical self-control by routine documentation of the exposure area product and duration of fluoroscopy on the other can markedly reduce the patient's exposure to X-rays.

Biopsy↗
PubMed1979

[Psychosomal dwarfism with reversible growth hormone deficiency (author's transl)].

The diagnosis of psychosocial dwarfism in a 9 year-old boy with severe growth retardation (-6 1/2 standard deviations) was deduced from the typical history. The bone age was severely retarded and in the first days after admission a deficiency of growth hormone and other pituitary hormones was established. The change in environment per se led to a spontaneous reversal of the growth hormone deficiency within a short time. A rapid catch up growth was observed over the subsequent 2 1/2 years, as well as a normalisation of the psychological retardation.

Age Determination by Skeleton↗
PubMed1979

[Oligosymptomatic manifestation of congenital hypothyroidism (author's transl)].

A 4-year-old girl with congenital dysgenesis of the thyroid gland is reported. The girl's appearance was that of hypothyroidism in childhood but the classical symptoms of constipation and cerebral retardation were missing. Thus it is assumed that relative insufficiency of the ectopic thyroid at the base of the tongue produced manifestations only a short time before diagnosis, having had no influence on cerebral maturity.

Age Factors↗
PubMed1977

[Cholelithiasis in children and adolescents (authors transl)].

Cholelithiasis is a rare, but important condition to be considered in the differential diagnosis of abdominal symptoms in childhood and adolescence. A survey over a 20-year period revealed 10 cases between the ages of 11 and 20 years, with a clinical history of cholelithiasis of between 5 days and 6 years. The most consistent finding was epigastric or right upper quadrant pain. Serum chemistry did not contribute conclusively towards the diagnosis. Hereditary spherocytosis was demonstrated in 3 cases, 2 had familial gall bladder disease, whilst in the rest no cause could be found. Two patients are described in some detail: one girl with spherocytosis and a bilirubin of 78 mg/100 ml, presenting with choledochal obstruction and pancreatitis, and another girl with a history of recurrent abdominal pain, negative radiologial and chemical pathological findings and a tentative diagnosis of neurosis. Oral cholecystograms lead to the diagnosis in most cases; however i. v. cholangiograms should be considered whenever the diagnosis appears in doubt. All cases were treated by cholecystectomy and recovery was uneventful in 9 patients. Cholecystectomy should be performed in all patients with gall stones, even in the absence of symptoms.

Adolescent↗
PubMed1976

[Overflow incontinence (author's transl)].

The encopresis of faecal impaction is a paradoxical incontinence found with constipation or faecal retention due to somatic or psychic causes. Normal continence comprises the possibility to delay passages of stools and the avoidance of leakage of stool in the meantime. Continued delay of defaecations causes faecal impaction and paradoxical leakage of stool. It is necessary to break the vicious circle by emptying the rectal ampulla and to avoid further constipation by means of laxatives and diet. Uderlying psychological disturbances must be recognized and treated. Two individual cases among our patients illustrate various aspects of the problem.

Child↗
PubMed1976

[Immunological studies in childhood coeliac disease (author's transl)].

The predominance of IgA-containing plasma cells over IgM-containing plasma cells in the normal small bowel mucosa is well documented. In coeliac patients relatively higher numbers of IgM-positive cells were found by several authors in varying degrees. We investigated the proportion of IgA-, IgM and IgG- containing plasma cells in small bowel biopsy material from 21 coeliac children and 24 controls by means of the immunofluorescent double-staining technique. A greater increase of IgM-cells than has previously been described was found. Additionally anti-reticulin antibodies, precipitating antibodies to gliadin and immunoglobuline levels in the serum were determined and tissue typing was performed in a number of these children, and the correlations of these single results were studied. Although these immunological investigations can not substitute the examination of small bowel mucosa biopsies by means of the dissecting microscope and conventional histological methods, they are a valuable diagnostic aid and could help to avoid unnecessary repeat biopsies. They are of help in monitoring the course and therapy in coeliac patients.

Adolescent↗
PubMed1976

Creatine kinase isoenzymes in cerebrospinal fluid in a case of brain damage.

We present a case of a 11/2-year-old boy with toxic enteritis, consecutive consumption coagulopathy, and sever brain damage. During the acute phase we found high activity of the BB isoenzyme of creatine kinase in cerebrospinal fluid, but not in the serum. Isoenzyme MM could also be found in the spinal fluid (37.9% of the total activity). We conclude that analysis for creatine kinase isoenzymes in spinal fluid is of clinical importance.

Brain Injuries↗