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Biomedical subjects

G Griffith

Publications and source records attributed to G Griffith.

7 recordsLinked to original sources
PubMed1990

Malignant left-sided large bowel obstruction managed by subtotal/total colectomy.

Of 60 patients presenting with acute obstructing carcinoma of the left colon, 49 underwent immediate resection either by radical subtotal/total colectomy (31 patients, group I) or by radical segmental resection (18 patients, group II) of whom three had immediate anastomosis after on-table bowel irrigation and 15 had a planned staged procedure. The operative mortality rate was 3 per cent in group I and 11 per cent in group II (not a statistically significant difference). However, substantial differences were found for major morbidity (6 versus 44 per cent in groups I and II respectively; P less than 0.01) and mean length of hospital stay (17 days in group I versus 35 days in group II; P less than 0.05). All three patients who had on-table lavage developed anastomotic leaks which necessitated a second operation to form a stoma. Six patients (19 per cent) in group I required antidiarrhoeal medication in the immediate postoperative period. However, subsequent improvement in stool frequency was noted in all patients. It is concluded that subtotal/total colectomy is an acceptable means of managing patients with obstructing carcinoma of the left colon in that it is associated with a low morbidity and mortality rate and good functional results.

Aged↗
PubMed1989

Altered laryngeal function following thyroidectomy.

The laryngograph was used to record and compare the voice changes in 11 thyroidectomy patients and 14 controls. The frequency histogram was studied and the change in its spread following surgery used to identify abnormal vocal fold movements due to recurrent laryngeal nerve damage. It also demonstrated changes which occur in thyroidectomy patients and not in patients having other operations. The possible causes include external laryngeal nerve damage.

Adult↗
PubMed1988

Plasma lipoproteins in neonatal, preruminant, and weaned calf.

This study compared plasma lipoprotein fraction profiles and lipid composition in the calf at 3 d, 3 wk, and 12 wk (weaned). For all ages the major plasma lipoprotein fraction was high density lipoproteins (52 to 73%), followed by very high density lipoproteins (10 to 22%), low density lipoproteins (13 to 18%), and chylomicrons plus very low density lipoproteins (5 to 9%). Most plasma lipid was cholesterol esters (41 to 49%) and phosphatidylcholine (21 to 29%). Most cholesterol esters (66 to 81%) and phosphatidylcholine (68 to 80%) were in high density lipoproteins; free fatty acids (83 to 96%) and lysophosphatidylcholine (75 to 85%) in very high density lipoproteins; and triglycerides (93 to 98%) in the remaining lipoprotein fractions. Of the three ages studied, 3-d-old calves had comparatively low plasma total lipids, high density lipoproteins, cholesterol esters, phosphatidylcholine, and linoleic acid in all lipid classes; they had relatively high plasma very high density lipoproteins, triglycerides, free fatty acids, phosphatidylethanolamine, and 20:3 n-9 fatty acid (indicative of essential fatty acids deficiency). Lipoprotein classes and lipid composition were similar at wk 3 and 12. Comparison of fatty acid profiles for phosphatidylcholine with those for lysophosphatidylcholine and cholesterol esters indicated plasma lecithin-cholesterol acyltransferase was active in calves at all three ages studied.

Aging↗
PubMed1979

Isolation and concentration of organophosphorus pesticides from drinking water at the ng/L level, using macroreticular resin.

A screening method has been developed for determining organophosphorus pesticides at ng/L levels in drinking water. Sixteen organophosphorus pesticides, diazinon, diazinon-oxon, dimethoate, ronnel, beta-phosphamidon, methyl parathion, ethyl parathion, malathion, chlorpyrifos, fenitrothion, ruelene, methidathion, ethion, EPN, phosalone, and phosmet, were extracted by Amberlite XAD-2 resin from 100 and 200 L drinking water previously spiked with these pesticides. The pesticides were eluted from the XAD-2 resin with acetone-hexane (15+85). The concentrated extract was analyzed by gas chromatography using a nitrogen-phosphorus selective detector and by gas chromatography-mass spectrometry using selected ion monitoring. Recoveries at the 10 and 100 ng/L spiking levels were greater than 90%, except recoveries for dimethoate and phosphamidon were 37 and 42%, respectively. The analysis of 300 L Ottawa tap water showed no detectable amounts (less than 1 ng/L) of any of the 16 organophosphorus pesticides.

Chromatography, Gas↗