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Biomedical subjects

G Grigorov

Publications and source records attributed to G Grigorov.

At least 19 recordsLinked to original sources
PubMed2003

Optimization of helical tomotherapy treatment plans for prostate cancer.

Helical tomotherapy (HT) is a novel treatment approach where the ring gantry irradiation geometry of a helical CT scanner is combined with an intensity-modulated megavoltage x-ray fan beam. An inverse treatment planning system (TomoTherapy Inc., Madison) was used to optimize the treatment plans for ten randomly selected prostate patients. Five different sets of margins (2, 5, 7.5 and 10 mm uniform 3D margins and a non-uniform margin of 5 to 10 mm) were employed for the prostate (GTV2) and seminal vesicles (GTV1). The dose distribution was evaluated in targets, rectum, bladder and femoral heads. HT plans are characterized by a rapid dose fall off around the target in all directions resulting in low doses (less than 30% of the dose at ICRU reference point) to the femurs in all cases. Up to a margin of 5 mm for target structures, it was always possible to satisfy the requirements for dose delivery set by RTOG protocol P-0126. Using a 'class solution', HT plans require minimal operator interaction and result in excellent sparing of normal structures in prostate radiotherapy.

Dose-Response Relationship, Radiation↗
PubMed1995

[The basic principles of the antibiotic therapy of burn patients].

Proceeding from many years experience with antibiotic treatment of bacterial infections in burnt patients, accumulated in the Section of Burns and Plastic Surgery, and pertinent literature reports, the basic principles of antibacterial therapy in this contingency of patients are set forth. A detailed protocol is presented, based on: 1) presence of clinical and laboratory evidence of infection and its location, and the most likely causing agents involved, 2) bacteriological data on the commonest causing agents of local and systemic infection in burns, and their sensitivity to antibiotics, 3) duration and surface, deepness and location of the burn injury, and 4) spectrum of action, pharmacokinetics, pharmacodynamics and side effects of the various groups of antibiotics, consistent with the age and concomitant diseases of the patients. A number of antibiotic constellations in cases presenting sepsis where resorting to "blind" therapy is necessitated, are recommended. It is underscored that the protocol suggested is open for modifications, and also that antibiotic therapy efficiency may be anticipated only when combined with adequate infusional and operative management.

Anti-Bacterial Agents↗
PubMed1989

[Acute pancreatitis].

Clinical records of acute pancreatitis for the period 1983-1987 are summarized. Included in the study were 312 cases. The morbidity curve showed biphasic age pattern. The increased diagnostic importance of blood and urinary alpha-amylase and of leucocytosis is emphasized; their levels were increased above the normal ones accordingly in 62.54 +/- 3.54%, 83.55 +/- 2.23% and 58.90 +/- 3.65% of the cases. Echographic examination of the abdominal organs is essential for the diagnosis. Sixty seven patients (21.48 +/- 0.2 per cent) were operated with case fatality rate 23.88 +/- 17%. Of those who received conservative treatment four died (1.63 +/- 0.81 per cent). kontrikal was applied in 91.99 +/- 1.60% of the cases. The overall mortality for five years was 6.41 +/- 1.39 per cent. Analysis was made of the number and type of operative interventions, the post-mortem finding and the complications. It is assumed that the rather good results of treatment of acute pancreatitis were due to the complex approach including lavage of bursa omentalis and the abdominal cavity in complicated cases, applied in the last 3-4 years.

Acute Disease↗
PubMed1980

[Infusion therapy via retrograde cannulation of the saphenous vein in burn patients].

This is a report on a method of retrograde vena saphena cannulation-peripherally in the internal malleolus region- for the purpose of carrying out infusion therapy, it was used in 47 patients with extensive burns, mainly children, with already exhausted possibilities of finding a venous source by routine procedures, the offered method meets fully the requirements of performing infusion resuscitation for a duration of 1-4 days. No side effects were recorded.

Burns↗