[Effect of nifedipine on peripheral blood flow in patients with atherosclerotic arterial disease of the lower limbs. A controlled study].
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Biomedical subjects
Publications and source records attributed to G Guerrera.
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The main cardiovascular problems caused by heroin addiction are examined, with particular emphasis on acute pulmonary oedema, the most dangerous and dramatic complication, of which the pathogenetic, clinical, diagnostic and therapeutic aspects are described.
Hyperuricaemia was encountered in 29% of 55 subjects with essential hypertension, who had not been treated with anti-hypertensive drugs, as against a 10% incidence in a group with normal blood pressure. No relationship between hyperuricaemia and level of hypertension was found. The normal glomerular filtration, the frequent reduction in uric acid clearance and its correlation with uricaemia are held to be indicative of a tubular defect in the excretion of uric acid, as a cause of hyperuricaemia. The reduction in renal plasma flow and its significant correlation with uricaemia and uric acid clearance are considered probable causes of reduced renal excretion. In conclusion it is hypothesised that hypertension triggers renal haemodynamic disturbances and hence hyperuricaemia.
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ECG abnormalities of various types and extent were noted in subjects with pheochromocytoma. In the majority of cases, they regressed after surgical resection of the tumour. The underlying pathogenetic mechanisms are discussed in the light of the functional and organic cardiac and vascular alterations induced by the abnormal increase in catecholamines. Reference is also made to the literature in support of the diagnostic and prognostic soundness of ECG with regard to both pheochromocytoma and any heart involvement it may cause.
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