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Biomedical subjects

G Guillet

Publications and source records attributed to G Guillet.

At least 19 recordsLinked to original sources
PubMed1995

[Darier-Ferrand dermatofibrosarcoma in children].

BACKGROUND: Dermatofibrosarcoma is a tumor relatively ignored in childhood. CASE REPORT: A 11 year-old boy was referred because he suffered from a tumor of the neck, which had progressively developed after a cervical traumatism occurring 4 years earlier. Examination showed a tumor moderately infiltrated, attached to the overlying erythematous skin. Biopsy showed ill-limited dermal and hypodermal proliferation of fusiform cells with a storiform arrangement. Two successive excisions were necessary and the patient is well 2 years later. CONCLUSION: This case confirms responsibility of previous traumatism, progressiveness of course and necessity of large excision.

Child↗
PubMed1993

Prognostic significance of cytotoxic T cells in individuals infected with human immunodeficiency virus.

Nine dual-fluorescence combinations were used to enumerate T-cell subsets in 112 human immunodeficiency virus type 1-infected patients. Two blood samples were analyzed, with a 6-month interval between the tests, in 53 of these 112 patients. The alteration in CD4 over this period of time correlated with the change in CD8 and CD8S6F1 (P < 0.02 and P < 0.01), irrespective of the disease stage. Two groups of patients were defined by the CD8S6F1 subset at the first normal levels. Changes in numbers of CD4, CD4CD45RA, and CD4CD29 were significantly higher in group B than in group A patients. The absolute count of CD8S6F1 could thus serve as an indicator of the ensuing depletion of the CD4 population, as well as the CD4 subsets.

Adolescent↗
PubMed1992

Natural history of sensitizations in atopic dermatitis. A 3-year follow-up in 250 children: food allergy and high risk of respiratory symptoms.

BACKGROUND AND DESIGN: The aim of the study was to define the natural history of sensitization in atopic dermatitis (AD) through cross-sectional (comparison of three age classes) and longitudinal study: 250 children with minor (32.5%), moderate (32.5%), and severe (35%) AD were examined for aeroallergen and food hypersensitivity (skin tests, clinical scoring after allergen elimination, and food challenges). RESULTS: The allergic screening was negative in minor AD and positive in 33% of cases of moderate AD that were concerned with aeroallergen sensitizations with only limited respiratory involvement. This suggests that nonspecific cutaneous hyperreactivity remains an almost exclusive precipitating factor in moderate or minor AD. Severe AD was characterized by a positive allergologic assessment in 100% of patients: food allergens were incriminated as flare factors in 96% of patients, with associated aeroallergen sensitization in 36%. Even at a young age (less than or equal to 2 years), the severe AD group is marked by an extreme frequency of food sensitization (93%) that persists in 73% of children younger than 7 years and 67% younger than 16 years. From the comparison of three age classes, the sequence of food and respiratory sensitization seems to be part of the natural course of AD. Prospective study in 29 children of group 1 (less than 2 years) with a 3-year follow-up confirms the data of the cross-sectional study since 27 had development of aeroallergen sensitization, with respiratory symptoms as early as age 3 years in 23 of these children. CONCLUSION: The detection of food allergy in a child presenting with AD is likely to indicate a prognosis of severe AD and should be considered by dermatologists as a potentially important predictor of further respiratory symptoms.

Child↗
PubMed1992

[Progressive and confluent hypomelanosis of the melanodermic metis].

Melanodermic half-castes may develop a progressive and extensive hypomelanosis presenting as an original skin condition. The course of the disease is characteristic: it occurs mainly in females from 18 to 25 years of age with a progressive development of hypochromic and coalescent macules on the back and abdomen. This disease may regress spontaneously within 5 years and healing seems to be facilitated by UV exposure. Decreased epidermal melanin is the only histological feature. Ultrastructural examination has led to characterize this bizarre disease by a switch from stage IV single melanosomes negroid type to small type I-III aggregated melanosomes (caucasoid phenotype of melanogenesis). Although the pathogenesis of the disorder remains obscure, it may be stated that the variation in skin coloration in these patients is due to a variation in melanosome size and distribution. It is possible that this variation is due to a decrease in production of type IV melanosomes and that this apparent change of ultrastructural phenotype represent the consequence of a simple imbalance in melanosomes production favoring small I to III melanosomes. This disease is not restricted to a limited geographic group: it is present in melanodermic half-castes of different areas and therefore deserves to be known and recognized.

Adult↗
PubMed1991

Identification of a 220 kDa membrane-associated plant cell protein immunologically related to human beta-spectrin.

Electrophoretic analysis of low ionic strength extracts of tomato plant leaves revealed the presence of two proteins of apparent molecular weights of 240 kDa and 220 kDa which co-migrated with purified human erythrocyte alpha- and beta-spectrin subunits. Immunochemical analyses employing an affinity-purified polyclonal antibody to human erythrocyte beta-spectrin reacted specifically with the 220 kDa plant cell protein. Immunofluorescence microscopy indicated that the beta-spectrin antibody recognized an antigen which was primarily restricted to the peripheral areas of the cells. Collectively, these results suggest that the cells of higher plants contain polypeptides related to the spectrin family of proteins. It is proposed that the plant cell possesses a membrane skeleton which is structurally and perhaps functionally analogous to that of the animal cell.

Chromatography, Affinity↗