Biomedical subjects

G Gus

Publications and source records attributed to G Gus.

3 recordsLinked to original sources

PubMed1989

Reduced locomotor activity of rats made histidinemic by injection of histidine.

Acute histidinemia was provoked in 30-d-old male Wistar rats by injecting intraperitoneally either histidine alone (0.5 mg/g body wt) or histidine (0.25 mg/g body wt) plus the histidase inhibitor nitromethane (0.73 mg/g body wt). Histidase activity was approximately 90% inhibited in rats receiving nitromethane. Serum histidine in both groups reached levels similar to those of histidinemic patients. Rats were subjected to the open field behavioral task, and the number of rearings and crossings were counted. A consistently lower locomotor activity was observed in the histidinemic rats. It is proposed that reduced locomotor activity and its relationship to psychomotor development should be investigated in histidinemic children.

Animals↗

PubMed1989

A simple simulated public speaking test for evaluating anxiolytic drugs.

1. We evaluated the feasibility of using a simulated public speaking (SPS) test to assess the activity of anxiolytic drugs. SPS was achieved by requesting subjects to present a speech to an audiocassette recorder. Thirty volunteers were randomly assigned to one of three groups treated with 10 mg diazepam, 10 mg buspirone or placebo, under double-blind conditions. One h after drug administration, subjective states were measured by the Visual Analogue Mood Scale (VAMS), the State-Trait Anxiety Inventory (STAI) and by a Bodily Symptoms Scale (BSS). Heart rate and blood pressure were also recorded. 2. SPS induced both physiological and subjective changes characteristic of anxiety. Moreover, diazepam attenuated experimentally induced increases in excitement (as measured by VAMS) and agitation (as measured by BSS). Therefore, SPS using an audiocassette recorder is sensitive to a prototypical anxiolytic and may thus be a useful test for evaluating putative anxiolytics. 3. No effect was observed with the new anxiolytic drug buspirone. However, the present negative result may be explained by clinical data indicating that patients may experience a longer lag period before the onset of the anxiolytic effect of buspirone.

Adult↗

PubMedDate not supplied

[The patients' perception about their illness: a pilot study].

This preliminary study aims at inquiring the patients' perceptions about their own illness process. Therefore, 19 clinical inpatients from the Hospital de Clínicas de Porto Alegre interviewed. After a qualitative data analysis, it was observed that in a medical consultation there are, at least, two perspectives concerning the illness process. First, the physician's perspective, taking into account systems and organs structural and/or functional abnormalities (disease), and second, the patient's perspective, based on her or his perception of events that occur when getting sick (illness). In addition, the patient's perspective generally presents a preoccupation with the etiology of the disease. Keeping in mind these different viewpoints, it is crucial to establish the medical-patient dialog, aiming at reaching a better relationship between the patient and her/his physician.

Adult↗