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Biomedical subjects

G H Reynolds

Publications and source records attributed to G H Reynolds.

28 records · Page 2Linked to original sources
PubMed1976

National gonorrhea therapy monitoring study: adverse drug reactions.

The Center for Disease Control and cooperating clinics monitored adverse drug reactions in 6,969 patients who were treated for suspected uncomplicated gonorrhea with one of the four 1972 United States Public Health Service (USPHS) recommended regimens and returned for reexamination. Of those patients receiving the aqueous procaine penicillin G (APPG)-probenecid regimen, 2.0% had at least one adverse reaction and 0.18% experienced procaine reactions. No life-threatening reactions occurred. The overall reaction rates for the ampicillin-probenecid, tetracycline and spectinomycin regimens were 0.62%, 5.9%, and 0.61%, respectively. Our findings document the relative safety of the USPHS recommended regimens.

Drug Administration Schedule↗
PubMedDate not supplied

Gonorrhea in the United States: 1967-1979.

Sex-, race-, and age-specific gonorrhea cases and rates reported by public and private sources were studied. The role of the age, sex, and race composition of the population was used to explain changing trends of morbidity due to gonorrhea. Beginning in 1967, reported cases of gonorrhea in the United States increased at an annual rate of 13% through 1975, with increases in women twice those in men. The group aged 20-24 years had the highest age-specific rates of gonorrhea in both men and women, while the highest percentage increases were observed in the 15-19-year-old age group. Since 1975, numbers of reported cases have stabilized. Decreases in rates of gonorrhea were more pronounced in men than in women. Among all ages, the group aged 20-24 showed the largest decrease for race and sex categories, except for nonwhite women.

Adolescent↗
PubMedDate not supplied

Syphilis in the United States: 1967-1979.

Reported data on cases of primary and secondary syphilis in the United States during 1967-1979 were analyzed by age, race, sex, and reporting source. Although the incidence of primary and secondary syphilis fluctuated little in the United States between 1967 and 1979, the ratio of male to female cases increased twofold, from 1.5:1 to 3:1. Cases in men, primarily those aged 25-39 years, reported by public clinics increased from 32% to 56% of the total cases reported; in particular, cases among white males reported by public clinics increased by 351%. The percentage of white men with early syphilis who attended public clinics and who reported at least one male sex partner increased from 38% in 1969 to 70% in 1979. These findings suggest that an essential change occurred in the epidemiology of early syphilis in the United States: white gay men became proportionately more burdened by the disease, and increasing transmission of the disease occurred within this segment of the population in the United States.

Adolescent↗
PubMedDate not supplied

Therapy of uncomplicated gonorrhea due to antibiotic-resistant Neisseria gonorrhoeae.

Antibiotics available to treat uncomplicated anogenital infections due to beta-lactamase-producing Neisseria gonorrhoeae include spectinomycin, ceftriaxone, and clavulanic acid added to aqueous procaine penicillin G or amoxicillin. Important variables in deciding which antibiotic regimen to use include effectiveness against urethral, cervical, pharyngeal, and rectal infections; cost; eradication of coexisting incubating syphilis; adverse effects; efficacy against strains of N. gonorrhoeae with chromosomally mediated resistance to antimicrobial agents; ease of administration; patient acceptance; and the potential for inducing resistance to antimicrobial agents in pathogens other than those causing sexually transmitted diseases. This review outlines the advantages and disadvantages of the various regimens.

Anti-Bacterial Agents↗