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Biomedical subjects

G H WHIPPLE

Publications and source records attributed to G H WHIPPLE.

At least 19 recordsLinked to original sources
PubMed1964

DETECTION AND QUANTITATION OF FALLOUT PARTICLES IN A HUMAN LUNG.

Portions of an adult human lung were studied by autoradiography in order to detect the presence of fallout particles. The radioactivity in the remainder of the tissue was determined with a gamma-ray spectrometer. Four particles were found and their activities were determined. From the measurement for total-fission-product activity in the lung tissue it was calculated that there were approximately 264 particles in the right lung at the time of death.

Autoradiography↗
PubMed1960

Vitamin B12Co-60 readily passes the placenta into fetal organs and nursing provides B12 from mother to pup. A record of its distribution.

The placenta is permeable to B(12)Co(60). Together with salts, sugar, amino acids, vitamins, and proteins, the B(12) is contributed to the growing embryos from the mother's body stores. At birth, the placenta contains a liberal amount of B(12), which the mother regains by ingestion of the placentas. Nursing draws a liberal amount of B(12)Co(60) from the mother's stores and contributes it to the body of the pups where it is absorbed and distributed in the various organs, much as noted when adult dogs are injected with B(12)Co(60). A redistribution is noted as the months pass; but the high values in the heart, liver, and gastric mucosa persist, and the brain usually shows a slow increase. Enterohepatic circulation of B(12) may involve bile and enteric content plus hepatic, gastric, and pancreatic epithelial secretion. This type of body recycling of radioactive B(12) is discussed but not proven. High values of B(12) in the heart, brain, gastric mucosa, and liver indicate that the vitamin is functionally active, not an inert fraction.

Adult↗
PubMed1959

Depletion of reserve protein from extravascular extracellular fluid; C14 labeling of plasma proteins in dogs after plasmapheresis.

During protein depletion produced by plasmapheresis and a very low protein diet there is a proportionately greater decrease in extravascular, extracellular fluid protein than in plasma protein. A shift in the normal ratio of protein in these 2 compartments, approximately 1 to 1 in the dog, to over 2 to 1 as a result of depletion indicates an important, labile source of reserve protein for the plasma in the interstitial fluids. This reserve source is limited since a maximum drop of 50 per cent in the total exchangeable pool and of 75 per cent in the extravascular, extracellular protein occurred after both shorter and longer periods of depletion. Under the rigid conditions of these experiments additional plasma protein removal was associated with loss of weight despite adequate caloric intake. Investigation of the status of the interstitial fluid proteins in other conditions associated with disturbed protein metabolism seems warranted.

Animals↗
PubMed1958

Vitamin B12Co60 distribution in dog tissues during many months; red cell stroma with labeled B12 in hemolytic anemia.

Experiments dealing with the distribution of B(12)Co(60) in the dog indicate that with time (9 months after administration) there is a shift in the distribution of the vitamin as compared to the short term experiments, as well as prolonged retention of the vitamin within various dog tissues. The heart, gastric mucosa, liver, spleen, and brain show high concentrations of the isotope in long term experiments. This distribution, in the heart for example, does not fit with an hypothetical breakdown of B(12)Co(60) complex and storage of a physiologically inactive fraction. Repeated periods of anemia produced by phenylhydrazine make it possible to demonstrate radioactive material in red cell stroma of dogs that have previously received vitamin B(12)Co(60). This radioactive material must have come from other body stores, such as liver and stomach. The high concentration of B(12)Co(60) in the gastric mucosa suggests a relationship between it and the intrinsic factor as described by Castle.

Anemia↗