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Biomedical subjects

G Høvding

Publications and source records attributed to G Høvding.

At least 37 records · Page 2Linked to original sources
PubMed1992

Epikeratophakia for keratoconus in mentally retarded patients. The use of fresh, free-hand made lamellar grafts.

Epikeratophakia for keratoconus was done in 11 mentally retarded patients, using fresh, free-hand made lamellar grafts. The mean follow-up period was 31.5 months. The grafts remained clear and well adapted in 7 cases (63.6%). Necrosis of the lower part of the graft occurred in 3 eyes (27.3%), and was probably caused by persisting epithelial defects. Only one of these grafts had to be removed. Despite concurrent eye diseases, such as cataract and possible amblyopia, an improved overall visual function was reported in 5 of the 11 patients (45.5%). No vision-threatening complications related to the epikeratophakia surgery was found.

Adult↗
PubMed1991

Multiple-dose, dose-response relationship for the topical carbonic anhydrase inhibitor MK-927.

The multiple-dose, dose-response curve of MK-927 was studied in a five-center, double-masked, randomized, placebo-controlled, parallel study of 2%, 1%, and 0.5% MK-927 in 76 patients with bilateral primary open angle glaucoma or ocular hypertension and intraocular pressure greater than 24 mm Hg following washout of ocular hypotensive medications. Patients received doses at 8 AM and 8 PM for 14 days, and parallel 12-hour intraocular pressure curves were performed prestudy and on day 14, with 4-hour curves on days 1 and 4. There was a significant dose-response relationship, with 0.5% MK-927 twice daily being a minimal-effect dose. Both 1% and 2% MK-927 were active through 12 hours postdose, and peak mean percent decrease in pressure at 2 hours postdose was 18.6% and 20.6%, respectively.

Administration, Topical↗
PubMed1990

[Contact lenses].

Explore the source record for details and available documents.

Contact Lenses↗
PubMed1990

Keratoprosthesis. I. Results obtained after implantation of 12 one-piece prostheses. A retrospective, follow-up study.

A total of 12 one-piece keratoprostheses were implanted in 6 eyes of 6 different patients with bilateral blinding, severe corneal disease with no possibility for a successful corneal transplantation. The prosthesis and the surgical procedure used are described. The short-term results were good, with 4 of the 6 patients obtaining a substantial visual improvement. In the remaining 2 patients preexisting pathology in the posterior segment of the eye was strongly suspected. However, the long-term complication rate was high, the chief problems being tissue necrosis around the prosthesis with eventual prosthesis loss and the development of retroprosthetic membranes. Repeated replacements of keratoprostheses extruded or removed because of complications were possible with restoration of the vision obtained after the first implantation.

Adult↗
PubMed1990

Keratoprosthesis. II. Results obtained after implantation of 27 dismountable two-piece prostheses. A retrospective, follow-up study.

During the years 1974-1987 a total of 27 two-piece keratoprostheses were implanted in 25 eyes of 22 different patients with bilateral blinding anterior segment disease with no possibility for a successful corneal transplantation. The prosthesis design and the surgical procedures used are described. The healing in and fixation of the prostheses were initially good in all cases, but 9 prostheses were lost or removed because of complications during the postoperative period of observation. The prosthesis retention time was significantly longer than that earlier achieved by the use of a one-piece prosthesis. In 18 of 27 cases a visual acuity of 6/60 or better was obtained. Postoperative complications included necrosis of the tissues covering and supporting the prosthesis, infection around the prosthesis, overgrowth of the surrounding tissues and the development of dense retroprosthetic membranes. Despite the obvious risks, keratoprosthesis surgery in a small number of patients with severe corneal disease represents the only potential hope for a visual rehabilitation, and should therefore be considered.

Adult↗
PubMed1990

Twelve-hour IOP control obtained by a single dose of timolol/pilocarpine combination eye drops.

The 12 h IOP control achieved by a single application of a newly developed ophthalmic solution containing 0.5% timolol and 2% resp. 4% pilocarpine was compared with that obtained by 1 dose of timolol 0.5% alone in 33 patients with manifest open angle glaucoma or ocular hypertension. The combined solutions gave a significantly better 12 h IOP control, evidenced by both a reduced mean diurnal IOP and a decreased frequency of larger pressure peaks.

Administration, Topical↗
PubMed1989

A comparison between acyclovir and trifluorothymidine ophthalmic ointment in the treatment of epithelial dendritic keratitis. A double blind, randomized parallel group trial.

This report presents the results of a double blind randomized study comprising 50 patients with epithelial herpes simplex keratitis. Twenty-five patients received 3% acyclovir ophthalmic ointment, the other 25 patients 2% trifluorothymidine (TFT) ophthalmic ointment. The mean duration of treatment in the 2 study groups before healing of the epithelial ulceration was obtained was 6.7 days and 5.9 days, respectively (no statistically significant difference). Two patient (8%) in the acyclovir group and 1 patient (4%) in the TFT group failed to heal within 14 days of treatment. No clinically significant adverse effects were recorded.

Acyclovir↗
PubMed1989

The prognosis of patients with hysterical visual impairment.

During the period 1962-1986, 54 patients received the diagnosis hysterical visual impairment, i.e. 1 out of every 631 patients admitted to our department. Isolated visual acuity impairment was the most common symptom, followed by combined visual acuity impairment and visual field constriction, whereas isolated visual field constriction occurred most infrequently. The mean age of the patients in the first group was significantly lower than that of the patients in the latter group. A questionnaire sent to all patients in 1987 was answered by 41 patients. Twenty-one of these (51%) felt that their visual function now was good, whereas 20 (49%) claimed that their visual function was still poor. Nine patients (22%) were disabled because of their visual problems. Twenty-nine of the patients who answered the questionnaire were re-examined. Sixteen of these (55%) still showed visual impairment at the follow-up, while 13 (45%) showed complete disappearance of visual complaints. The younger patients appeared to have a better prognosis than the older ones.

Adolescent↗
PubMed1987

Timolol/pilocarpine combination eye drops in open angle glaucoma and in ocular hypertension. A controlled randomized study.

The effect of a newly developed ophthalmic solution containing both 0.5% timolol and 2% resp. 4% pilocarpine was compared with that of timolol 0.5% eye drops alone in 93 patients with manifest simple or capsular glaucoma or ocular hypertension. The medications were administered twice daily. The absolute additive effect of pilocarpine was small, although the combined solutions caused a statistically significantly greater reduction of the intraocular pressure than that achieved by timolol alone. This additional effect appeared to last at least 12 h. The effect of the test solutions containing 2% resp. 4% pilocarpine was very similar. Apart from the well-known effects of the pilocarpine-induced miosis, the combined test medications were generally well tolerated.

Aged↗
PubMed1986

Prognostic factors in the development of manifest open angle glaucoma. A long-term follow-up study of hypertensive and normotensive eyes.

Ninety-three patients, who during a mass screening for glaucoma in 1962-63 attended a thorough ophthalmological examination, were re-examined in 1980-82. At the mass screening 42 patients had IOP greater than or equal to 21 mmHg in at least 1 eye, but none of the 93 patients had glaucomatous optic disc excavations or visual field defects. At the re-examination, 28 patients (30.1%) had developed manifest open angle glaucoma in at least 1 eye. This development was significantly correlated to the height of the IOP, both at the mass screening, during the period of observation and at the follow-up study (P less than 0.05-P less than 0.002). A reduced outflow facility measured at the mass screening was also significantly associated with the later development of manifest glaucomatous damage (P less than 0.05-P less than 0.01). In addition, fibrillopathy (pseudoexfoliation), manifest glaucoma in the 'fellow eye' and a positive family history for glaucoma were found to be important risk factors.

Adult↗
PubMed1984

Hydrophilic contact lenses in corneal disorders.

Hydrophilic 'bandage' lenses were fitted in 107 patients with corneal disorders not satisfactorily responding to conventional medical treatment. An over-all beneficial effect on both ocular discomfort, visual acuity and corneal disorder was found (P less than 0.002). Regarding each group separately only patients with bullous keratopathy and those with corneal ulcers achieved a significant reduction of ocular discomfort (P less than 0.002) and a significant improvement of visual acuity (P less than 0.05 - P less than 0.01). In bullous keratopathy corneal oedema was significantly reduced by concomitant use of contact lenses and 5% NaCl eye drops (P less than 0.01). Significant improvement of corneal disorder occurred in patients with corneal ulcers and in those with corneal lacerations (P less than 0.002 and P less than 0.01, respectively). Complications included corneal vascularization (7.5%) and keratitis/keratoconjunctivitis (5.6%). Prophylactic use of topical antibiotics appeared necessary only in dry eye disease.

Adolescent↗
PubMed1984

Deposits on hydrophilic 'bandage' lenses. A scanning electronmicroscopic and x-ray microanalytic study.

Scanning electronmicroscopy of 34 continuously worn Sauflon PW 'bandage' lenses showed an initial deposition of cellular debris, followed by an increasing, general, non-penetrating, organic coating, particularly on the anterior lens surface. No microorganisms were found. X-ray microanalysis of the 34 Sauflon PW lenses as well as 11 daily worn Hydroflex m lenses showed that elements may be added to or 'washed out' from the lenses during storage before preparation for microscopy. The elements obtained were constituents of both normal tear fluid and lens storage solutions. Only sulphur appeared firmly bound in the deposits, probably as sulphur-containing macromolecules of ocular mucus. Calcium was only detected in a few cases.

Contact Lenses, Hydrophilic↗
PubMed1983

Variations of central corneal curvature during the first year of contact lens wear.

During hard, hydrophilic and silicone lens wear the variations of central corneal curvature in the 2 eyes of each individual were significantly correlated. Mean changes of principal radii of curvature were small in each lens group (-0.075-+0.068 mm). Hydrophilic lens wearers showed an initial mean flattening of corneal curvature, followed by a significant steepening. Hard lens wearers apparently showed the opposite sequence of mean changes. Silicone lens wearers showed a significant mean corneal flattening. Central corneal asphericity was reduced during hard lens wear. Considerable individual curvature changes occurred (-0.35-+0.30 mm), but none of these necessitated lens refitting. Changes of the central corneal thickness and curvature during hard lens wear were apparently inversely correlated, the ratio between the changes being about -0.08:1. Hard and silicone lenses probably exerted a mechanical moulding effect. The exact aetiology of curvature changes in hydrophilic lens wearers remains obscure. Corneal curvature changes appear less reliable than corneal oedema in the detection of lens-induced impairment.

Adolescent↗
PubMed1983

Variations of refractive error during the first year of contact lens wear.

The variations of refractive errors during both hard, hydrophilic and silicone lens wear were significantly correlated in the 2 eyes of each individual. In each lens group the mean changes of spherical and cylindrical refractive errors were small (-0.458D-+0.250D and -0.325D-+0.056D, respectively). Considerable individual refractive changes occurred (spherical change: -3.0D-+1.5D, cylindrical change: -2.5D-+1.0D). However, only 2 subjects noticed spectacle blur and a normal visual acuity was always obtained by spectacle refraction immediately after lens removal. This indicated that clinically significant distortion of the central cornea did not take place. Hydrophilic lens wearers showed an increasing myopia during lens wear. Otherwise the refractive changes were not significantly influenced by the duration of lens wear. Refractive changes appeared to be significantly correlated to changes of the central anterior corneal curvature, the ratio of dioptric changes being about 1:1.

Adolescent↗
PubMed1983

A clinical study of the association between thickness and curvature of the central cornea.

The right eye of 105 healthy subjects aged 14-48 years were examined. The mean central corneal thickness was 0.532 mm. The mean horizontal and vertical radius of central anterior corneal curvature was 7.86 mm and 7.66 mm, respectively. The results indicated that some weak, positive association probably exists between the thickness and curvature of the central cornea, the coefficient of regression between the 2 parameters being about 1.5. Thus a thick cornea tends to be slightly flatter than a thin cornea.

Adolescent↗
PubMed1983

The fluid content of hydrophilic contact lenses on the eye.

Hydroflex m, Hydroflex 72 and Sauflon PW lenses were tested (declared fluid content 38.4%, 72% and 79%, respectively). At room temperature in vitro the mean fluid content of Hydroflex m and Sauflon PW was significantly higher than declared (P less than 0.002), but this might be due to insufficient blotting of the lens surface. The mean fluid content of Hydroflex 72 was about 2.5% lower than declared (P less than 0.002). During wear the fluid content of Hydroflex m did not differ significantly from the in vitro recordings at room temperature, while the fluid content of worn Hydroflex 72 and Sauflon PW was about 2% lower than in vitro (P less than 0.002). This difference was mainly due to the greater temperature susceptibility of these lens materials. Apart from a slight decrease during the first few h after insertion (P less than 0.05), the fluid content of the lenses was not significantly influenced by the duration of wear. The mean contact lens surface temperature during wear was 30.7 degrees C.

Clinical Trials as Topic↗