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Biomedical subjects

G HERTTING

Publications and source records attributed to G HERTTING.

At least 19 recordsLinked to original sources
PubMed1962

Actions of bretylium and guanethidine on the uptake and release of [3H]-noradrenaline.

The effect of bretylium and guanethidine has been studied on the uptake and the spontaneous and reserpine-induced release of [(3)H]-noradrenaline in the rat heart and in the splenic nerve endings of the cat. Bretylium and guanethidine inhibited the uptake by the heart of circulating [(3)H]-noradrenaline. Bretylium blocked spontaneous and reserpine-induced release of [(3)H]-noradrenaline, while guanethidine caused release and partially antagonized the reserpine-induced release. Both compounds produced a transient liberation of [(3)H]-noradrenaline from splenic nerves, but blocked the release of the [(3)H]-catechol amine following stimulation of the splenic nerve.

Amidines↗
PubMed1962

On the mechanism of tachyphylaxis to tyramine in the isolated rat heart.

Tyramine was shown to release [(3)H]-catecholamines from an isolated rat heart previously perfused with [(3)H]-noradrenaline. With successive injections of tyramine the amount of [(3)H]-catecholamine released fell progressively and there was a parallel decrease in the increment of amplitude and rate of contraction of the heart. Reserpinized hearts were shown to take up less [(3)H]-noradrenaline than normal hearts. Release of radioactivity and loss of responsiveness to tyramine occurred more rapidly in the reserpinized heart. In the same preparation the uptake of [(14)C]-tyramine exceeded the quantity of the noradrenaline released.

Animals↗