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Biomedical subjects

G Haddock

Publications and source records attributed to G Haddock.

50 records · Page 3Linked to original sources
PubMed1993

Gastric phytobezoar: unusual association and resolution.

A 58 year old man underwent a laparotomy for intestinal obstruction, which proved to be due to intestinal pseudo-obstruction. Following a slow postoperative course, he was discovered to have a gastric phytobezoar. The association between bezoars and pseudo-obstruction has not been previously described, but might be expected. The gastric phytobezoar could not be fragmented mechanically, but it completely disappeared when enteral feeding was commenced. The possibility of a future role of enteral feeding in this situation is suggested.

Bezoars↗
PubMed1992

Paediatric trauma in northern Iraq: the Kurdish refugee crisis.

In May 1991 a team of five doctors and two nurses from Edinburgh hospitals were flown to Northern Iraq to assist in the Kurdish refugee relief effort. The two surgical members of the team helped to re-establish surgical services in a small hospital in the Iraqi town of Zakho. During an 8-day stay in the hospital, frequently in extremely difficult circumstances, the surgical team undertook 19 major and 15 minor surgical procedures in 25 patients; 11 major and eight minor procedures were undertaken in 15 children under the age of 16 years. The largest group of children treated had suffered bomb-blast injuries from unexploded ordinance; injuries sustained were primarily to the hands, face and upper trunk. Road traffic accidents and burns were also common. Two children requiring postoperative intensive care were evacuated by military helicopter at night to hospital facilities in Turkey.

Adolescent↗
PubMed1991

The effect of the somatostatin analogue SMS 201-995 on experimental pancreatic carcinogenesis in the Syrian golden hamster.

Somatostatin analogues have been suggested as possible therapy for human pancreatic cancer. This paper investigates the effect of the somatostatin analogue SMS 201-995 (Sandoz) in the Syrian golden hamster model of nitrosamine-induced pancreatic carcinogenesis. Step-wise increasing doses of i.v. SMS 201-995 suppressed pancreatic juice output from a median basal value of 212 mg/kg body wt/h (Q1:Q3 = 121:334) to a median basal value of 70 mg/kg body wt/h during infusion of 5 micrograms/kg body wt/h of SMS 201-995 (Q1:Q3 = 64:102, P less than 0.05). Chronic s.c. injection of 5 and 10 micrograms/kg body wt SMS 201-995 twice daily for 3 days each week, did not affect pancreatic wet wt or pancreatic total DNA content after 1 or 6 weeks of treatment when compared to controls. The most interesting and unexpected finding in our study was that SMS 201-995 seemed to promote pancreatic carcinogenesis when administered in low dosage. More SMS 201-995 treated animals receiving 5 micrograms/kg body wt developed invasive pancreatic adenocarcinoma than controls after 15 weeks of carcinogen (4/10 animals versus 0/10, P less than 0.05, Fisher's exact test) and pancreatic involvement by tumour was more extensive (17/75 pancreatic blocks affected versus 0/71, P less than 0.001). When carcinoma in situ and microcarcinomata were analysed with invasive lesions, animals injected with 5 micrograms/kg body wt SMS 201-995 were still significantly more affected than controls (33/75 blocks versus 9/71, P less than 0.001). Hamsters injected with the higher SMS 201-995 dose (10 micrograms/kg body wt) did not show any increase in malignancy over the controls. These results suggest that the effect of SMS 201-995 on pancreatic carcinogenesis in the Syrian hamster is complex and varies with dose administered. Further work is required before its use on man can be justified.

Animals↗
PubMed1990

Aetiology of pancreatic cancer.

Curative surgery is possible in only a small minority of patients with pancreatic cancer and, to date, responses to chemotherapy and radiotherapy have been disappointing. To make any impact on the incidence of the disease a clearer understanding of its aetiology is required. This review explores present knowledge of the aetiology and epidemiology of pancreatic cancer.

Cholelithiasis↗
PubMed1989

Esophageal tamponade in the management of acute variceal hemorrhage.

Over a seven-year period, 138 patients with portal hypertension presented on 223 occasions with endoscopically proven acute variceal hemorrhage. Hemorrhage ceased spontaneously on 92 occasions (41%). On 126 occasions (57%) passage of the four-lumen modification of the Sengstaken-Blakemore tube was required, and hemorrhage was successfully controlled in 98%. Intubation was refused on five occasions (2%). Hemorrhage recurred during these 223 admissions on 47 occasions (21%); on 11 occasions a second rebleed occurred and on two occasions, a third. Tamponade was required during all of these rebleeds and arrest of hemorrhage was achieved in 87%. Hemorrhage in patients with poorer modified Child's grade was less likely to cease with intubation. The overall rate of control in the 186 episodes of hemorrhage requiring tamponade was 94%. There were 28 complications attributed to the use of tamponade in 186 episodes of hemorrhage (15%). On 12 occasions these complications proved fatal (6.4%). In four further patients failure of tamponade to control hemorrhage was fatal.

Adolescent↗
PubMed1989

99mTc-nanocolloid bone marrow scintigraphy in prostatic cancer.

Bone marrow scintigraphy was performed in 23 patients with histologically proven carcinoma of the prostate, using a new radiopharmaceutical, Technetium-99m nanocolloid. The results suggest that although bone marrow scintigraphy is less sensitive than conventional bone scintigraphy in the detection of skeletal metastases from prostatic carcinoma, the technique may have a place in the management of patients with advanced metastatic disease, especially those who are anaemic, by identifying those patients at risk from myelosuppressive therapy.

Adult↗
PubMed1989

Metastatic vipoma arising from colonic primary tumour.

We describe a case of a tumour of the sigmoid colon with hepatic metastases in a patient with previously documented ulcerative colitis. A diagnosis of metastatic vipoma was made on the basis of high plasma levels of vasoactive intestinal polypeptide (VIP). Profuse diarrhoea and profound metabolic upset were corrected by the use of a somatostatin analogue SMS 201-995, whilst conventional cytotoxic therapy produced a significant tumour response with return of the plasma VIP level to normal.

Adenoma, Islet Cell↗
PubMed1988

Survey of antibiotic prophylaxis in gastrointestinal surgery in Scotland--5 years on.

The results of a 5-year follow-up survey of the use of prophylactic antibiotics in gastrointestinal surgery in Scotland are reported. There have been significant increases in the routine use of prophylactic antibiotics during elective cholecystectomy (21% to 53% of surgeons; P less than 0.001) and appendicectomy (49% to 79% of surgeons; P less than 0.001). In addition a substantial number of surgeons used prophylactic antibiotics in selected high risk patients undergoing biliary tract surgery and gastroduodenal surgery.

Anti-Bacterial Agents↗
PubMed1987

Polyorchidism.

Polyorchidism is an unusual abnormality of the genital tract in which supernumerary testes are present, usually within the scrotum. We report a recently encountered case, discuss the aetiology of the condition and suggest a course of management when encountered at operation.

Adolescent↗
PubMedDate not supplied

Resettlement of long-stay psychiatric patients.

A follow-up study of patients from two long-stay psychiatric hospitals in East Yorkshire health authority looked at a sample of patients who had been discharged into the community and a sample within the institution. The study looked particularly at the quality of life of patients who had been discharged and at any differences between them and patients still living in the institution.

Consumer Behavior↗