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Biomedical subjects

G Hartwich

Publications and source records attributed to G Hartwich.

At least 19 recordsLinked to original sources
PubMed1986

[Type identity of the swine parasites Globocephalus longemucronatus and G. urosubulatus (Nematoda, Strongyloidea)].

On the basis of a critical analysis of the literature and of our own investigations, it is pointed out that the two hookworm species known from European swine, namely Globocephalus longemucronatus Molin, 1861 and G. urosobulatus (Alessandrini, 1909), are identical. All the differences hitherto used to distinguish these species are shown to be due to incorrect descriptions of the taxonomic characters or to misinterpretations of statements made by former authors. Accordingly, only one species of Globocephalus occurs in Europe, which has to be named G. longemucronatus Molin, 1861, with Crassisoma urosubulatum Alessandrini, 1909 as its junior synonym. A short diagnosis of this species is given.

Animals↗
PubMed1979

[Chemotherapy of bronchial carcinoma].

Prognosis of bronchial carcinoma remains poor despite improved early diagnosis and campaigns of informing the public about the risk factors. In the majority of histological entities chemotherapy cannot change this situation. However, in case of oat cell carcinoma a high rate of responders together with prolongation of survival rate can be achieved by chemotherapy. The best results are obtained with combined chemotherapy and early radiation therapy.

Antineoplastic Agents↗
PubMed1979

[Gamma globulin in secondary antibody deficiency syndrome].

12 patients with secondary antibody deficiency syndrome received a new gammaglobulin compound intravenously (lyoph. SRK Sandoz). The drug was given in a 3% NaCl-solution once to four times. At the end of the infusion of 6 g gammaglobulin and after one week, serum levels were significantly higher. Gammaglobulin intravenously was well tolerated in all cases. Severe infections during the period of treatment were not observed.

Antibody Specificity↗
PubMed1979

[A prospective multi-centre study of the response of metastatic gastrointestinal tumours (author's transl)].

In a prospective, multi-centre, randomized study of 109 patients with metastatic gastro-intestinal adenocarcinomas the response rate, survival time and side-effects of two drug combinations, carmustin +5-fluorouracil and carmustin + ftorafur, were compared (same carmustin dosage in both groups). Response to the treatment was 32.7% in those receiving carmustin +5-fluorouracil, 26.3% in those on carmustin + ftorafur. This difference occurred among the 42 patients with gastric adenocarcinoma (33.3% compared with 25%), as well as in 11 with pancreatic adenocarcinoma, and in 56 with colorectal adenocarcinoma (32.1% and 28.6%). Median survival time for 5-fluorouracil + carmustin was 330 days, double that for ftorafur + carmustin (163 days). Bone-marrow toxicity (leukopenia, thrombopenia) was below 10% for both drug combinations. Alopecia occurred in only a few patients. Gastro-intestinal toxicity was common (20% and 18.5%, respectively), but there was no difference between the two groups. The somewhat lower effectiveness of ftorafur compared with 5-fluorouracil was probably due to the deliberately smaller dosage of the former.

Adenocarcinoma↗
PubMed1979

[Clinical expressions of plasmocytoma (author's transl)].

Multiple myeloma is the most frequent type of hemoblastic disorders including paraproteinemia. Most cases show a disseminated involvement; few patients have solitary lesions of the bones or connective tissues. Different localizations are the reason for the multiform clinical picture of the disease. The main symptoms result from neurological and dermatological involvement, less usual are gastrointestinal complaints. Fractures, neurological deficiencies, lack of antibodies and failure of the kidneys determine the course of plasmocytoma. Our case reports are demonstrating examples of the different clinical expressions.

Aged↗
PubMed1979

[Ascaridia platyceri n.sp., a new species of nematode from parrots].

A new species of bird parasitic nematode, Ascaridia platyceri n. sp., is described from the small intestine of Platycerus eximius and 8 further species of Psittacidae maintained in Zoological Gardens and private holdings in the GDR. The new species differs from the 3 species of Ascaridia hitherto known from parrots mainly in the shape of the anterior border of the lips as well as in the number and position of the caudal papillae in the male.

Animals↗
PubMed1978

[Treatment results of therapy resistant acute leukemias with 7 cystostatic agents (TRAMPCO-scheme)].

Treatment of therapy-resistant acute leukemia with 7 cytostatics (TRAMPCO) 13 adult patients with acute leukemia, primarily and secondarily resistant to other combined therapy, as well as 2 untreated patients were treated with 7 cytostatic drugs according to the so called TRAMPCO-regimen. 5 complete remissions and 5 partial remissions were obtained corresponding to a degree of response of 66%. The duration of remission was relatively short with 1 to 5 months, in one case more than 6 months. The toxicity of the combined therapy could be tolerated, the personal subjective tolerance was good. The Trampco-regiment therefore represents a realistic possibility in the treatment of acute leukemia resistant to other forms of treatment.

Acute Disease↗
PubMed1978

[What are the dangers of splenectomy in Hodgkin's disease?].

Splenectomy is a surgical procedure of medium severity, the mean lethality rate is 1%, the complication rate 10 to 20%. The surgical risk is dependent upon age and general condition of the patient, the severity of the disease, and the experience of the surgeon. The risk of late complications due to surgery is determined mainly by infections as well as ileus, requiring relaparatomy. The risk of infections is higher in children than in adults: one has to be aware of miningitis and sepsis in about 10% of the patients; half of those cases end lethal. An analysis of advantages versus risks of splenectomy must be made for each patient individually. For optimal treatment it is necessary to know the stage of the disease. Concerning M. Hodgkin, explorative laparatomy combined with splenectomy should be performed in stage I to III A. If, however, the surgical risk is rather high primarily and if there are no therapeutical consequences to be expected, splenectomy should not be performed because of the known risks and disadvantages.

Adult↗
PubMed1978

[Plasmacytoma].

Plasmocytoma is generally a systemic disorder and has to be differentiated from solitary plasmocytoma of bones and connective tissue. Diagnosis is based on the typical bone marrow findings, the demonstration of monoclonal paraprotein and the radiological skeletal changes. Prognosis is poor, life expectancy limited to about 18 months. Specific therapy with cytotoxic drugs leads in many cases to marked improvement of the general condition, relative freedom of pain and a decreased complication rate.

Aged↗