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G Hasçelik

Publications and source records attributed to G Hasçelik.

34 records · Page 2Linked to original sources
PubMed1995

The effect of tonsillectomy on neutrophil chemotaxis in adults with chronic tonsillitis.

Neutrophil random motility and chemotactic responsiveness were determined in 17 healthy adults and 19 adult patients with chronic tonsillitis before and 10 days after tonsillectomy, using a modified Boyden chamber method. The mean chemotactic index values of the healthy controls were significantly higher when compared with the chronic tonsillitis patients before tonsillectomy. The postoperative mean chemotactic values were increased, and there was a statistically significant difference between the mean chemotactic index of neutrophils in preoperative and postoperative patients. The authors conclude that this change in host defense mechanism may be the reason for frequent attacks of acute tonsillitis in these patients.

Adult↗
PubMed1993

Effect of povidone-iodine lavage on peritoneal defence mechanisms in rats.

OBJECTIVE: To assess the effect of povidone iodine lavage on peritoneal defence mechanisms in rats. DESIGN: Randomised study. MATERIAL: 90 Wistar albino rats. INTERVENTION: Rats were divided in three groups of 30. All rats underwent midline laparotomy, and 20 rats in each group had peritoneal lavage with 20 ml 1% povidone iodine, samples being taken before lavage in 10 and after lavage in 10. MAIN OUTCOME MEASURES: Effect of povidone-iodine lavage compared with laparotomy alone on bactericidal activity of peritoneal fluid (group 1); chemotactic indices of polymorphonuclear leucocytes (PMNL) (group 2); and total cell counts, cell types, and peritoneal phagocytic activity (group 3). RESULTS: Lavage with povidone-iodine increased the total peritoneal cell count/washing from 10.4 x 10(6) to 12.4 x 10(6) (p < 0.005), peritoneal bactericidal activity from 69.2% to 92.7% (p < 0.05), and peritoneal phagocytic activity from 58.9% to 73.7% (p < 0.05) at the end of four hours. Chemotactic indices of peritoneal PMNL before and after lavage were 1.90 and 1.89, respectively. Among the cells in the peritoneal fluid, the proportion of PMNL increased, whereas those of macrophages, lymphocytes, and mast cells decreased (p < 0.005). CONCLUSIONS: These results differ from those that we found previously after saline lavage. Lavage with 1% povidone-iodine does not increase the detrimental effect of saline lavage; on the contrary, it may even enhance peritoneal defence mechanisms. Any detrimental effects of povidone-iodine lavage should be attributed to systemic rather than local toxicity.

Animals↗
PubMed1992

Acute experimental unilateral orchitis in the rabbit and its effect on fertility.

We examined the nature of contralateral damage following unilateral orchitis to see if an immunologically mediated mechanism was present. Experimentally induced orchitis in 18 white New Zealand rabbits were examined and compared to 20 in the control groups. Serum antisperm antibody presence and bilateral testicular biopsies (Johansen biopsy score, mean seminiferous tubule diameter) were examined and pregnancy rates were noted. Acute orchitis seemed to be a causative factor in production of antisperm antibody and the presence of antisperm antibody caused histologic changes in contralateral testicles and therefore impaired fertility.

Acute Disease↗
PubMed1991

[The invitro activity of teicoplanin and vancomycin against gram positive microorganisms (corrected)].

The in vitro activities of teicoplanin and vancomycin against 288 gram positive cocci were determined by broth macrodilution method. MIC 90 values for teicoplanin were lmcg/ml for coagulase positive staphylococci (n = 115), 4 mcg/ml for coagulase negative staphylococci (n = 93), 0.50 mcg/ml for S. faecalis (n = 50) and 0.125 mcg/ml for S. pyogenes (n = 30). MIC 90 values for vancomycin were lmcg/ml 1 mcg/ml, 1 mcg/ml and 0.25 mcg/ml respectively. We were not able to detect in vitro resistance against teicoplanin and vancomycin.

Anti-Bacterial Agents↗
PubMed1990

[In vitro activity of aztreonam, cefoperazone and ceftriaxone against gram-negative bacteria].

In this study, the in vitro activity of aztreonam was compared with that of cefoperazone and ceftriaxone against 1000 gram-negative bacilli. Among gram-negative bacteria, resistance to aztreonam, cefoperazone and ceftriaxone were noted 2.7%, 11.3%, 11.5% respectively. The results obtained in this study indicate that aztreonam is highly effective against gram-negative bacilli.

Aztreonam↗
PubMed1990

[Comparison of the in vitro antibacterial activity of ofloxacin and nalidixic acid].

The in-vitro activity of ofloxacin and nalidixic acid was determined against 964 Gram-negative and 66 Gram-positive isolates from different clinical specimens. Ofloxacin showed excellent in vitro activity against Enterobacteriaceae. The compound was significantly more potent than nalidixic acid against Pseudomonas spp. Acinetobacter spp. and Staphylococcus spp. We conclude from our studies that ofloxacin could be a valuable therapeutic agent with a variety of indications.

Acinetobacter↗
PubMed1990

[Group B streptococcal endocarditis].

In this article, a case of group B streptococcal endocarditis in a diabetic patient, taking immunosuppressive therapy because of dermatomyositis is reported.

Dermatomyositis↗
PubMed1989

[Frequency and in vitro antibiotic sensitivity of bacitracin-resistant beta-hemolytic streptococci from throat swab specimens].

The recovery of beta-hemolytic streptococci from throat specimens, from November 1, 1988 to January 6, 1989, was analyzed. Beta-hemolytic streptococci were isolated from 927 of the 5050 throat cultures (18.4%). The rate of isolation of bacitracin-resistant beta-hemolytic streptococci was 9.6%. The frequency of group B, C, D, F and G beta-hemolytic streptococci was found 14.6%, 38.2%, 3.4%, 1.1% and 42.7% respectively. All strains were susceptible to penicillin, erythromycin and clindamycin.

Bacitracin↗
PubMed1989

[In vitro susceptibility of Campylobacter jejuni and Campylobacter coli to quinolone antibiotics].

In this study, in vitro susceptibilities of 24 campylobacter strains isolated from fecal samples were tested for quinolone antibiotics. 13 of the strains were identified as C. jejuni and 11 of them were C. coli. Antibiotics which were included in this study were ciprofloxacin, ofloxacin, pefloxacin and fleroxacin. Antibiotic susceptibility tests were performed on Mueller-Hinton agar (supplemented with 5% sheep blood) using the agar dilution method. Results showed that quinolone antibiotics are very active against Campylobacter species. There was not any marked difference between the susceptibility patterns of C. jejuni and C. coli.

Anti-Infective Agents↗
PubMed1989

[HBeAg and anti-HBe levels in HBsAg positive blood donors].

Serum samples from 110 blood donors who were carriers of hepatitis B surface antigen (HBsAg) were examined for the presence of hepatitis Be antigen (HBeAg) and its antibody. HBeAg was detected in 21 (19.09%) and anti-HBe in 87 (79.09%) blood donors. No significant association were found with blood groups and HBeAg or anti-HBe. The analysis of serum samples for HBeAg and anti-HBe at the blood transfusion centres, will be useful for determining if HBsAg carriers are infectious.

Blood Donors↗
PubMed1987

[The role of ofloxacin (Tarivid) therapy in respiratory and urinary tract infections].

In this study, 14 patients with urinary tract infection and 8 patients with respiratory tract infection were given 400 mg/day of ofloxacin. 12 of 14 patients with urinary tract infection and 4 of 8 patients with respiratory tract infection was cured and clinically improved. 12 of 13 E. coli isolates were eradicated with this treatment. No severe adverse reactions were observed. No in vitro resistance against ofloxacin was seen.

Acute Disease↗
PubMed1987

[A comparison of manual methods and enterotube II (Roche) for the identification of gram-negative enteric bacteria isolated from feces].

The Enterotube II and classic manual methods were used in parallel to identify 100 members of the enteric bacteria isolated from feces culture. Among these isolated bacteria Shigella, Salmonella and E. coli were found 34%, 25%, 22% respectively. The Enterotube II and classic manual methods gave the same results for identification of Salmonella and Shigella. The Enterotube II correctly identified 98% of all gram negative enteric bacteria. Other advantages and disadvantages of these methods are discussed in our study.

Bacteriological Techniques↗
PubMedDate not supplied

Effect of some anti-inflammatory drugs on human neutrophil chemotaxis.

The effects of piroxicam, tenoxicam, diclofenac sodium, acetylsalicylic acid and tiaprofenic acid on the chemotaxis and random migration of human polymorphonuclear leukocytes were investigated, using zymosan-activated serum as chemo-attractant, with a modified Boyden chamber technique. All five compounds significantly reduced chemotaxis. The random migration of polymorphonuclear leukocytes was inhibited by piroxicam, diclofenac sodium and tiaprofenic acid but not by tenoxicam or acetylsalicylic acid. The inhibitory effect of these non-steroidal anti-inflammatory drugs on polymorphonuclear leukocyte chemotaxis and on random migration was generally dose-dependent. The results suggest that the drugs studied may have a direct effect on polymorphonuclear leukocyte chemotaxis and that this activity may contribute to their anti-inflammatory properties.

Adult↗
PubMedDate not supplied

Helicobacter felis as a cofactor alone or together with stress in cryptosporidial activation in mice.

Cryptosporidiosis is caused by a protozoan parasite, mainly found in animals, which usually results in transient, mild gastroenteritis in humans but can cause severe and prolonged disease in immunocompromised individuals. Immunocompetent mice, naturally infected with Cryptosporidium muris, were used to investigate the effects of inoculation with Helicobacter felis and of stress on the activity of the C. muris infection, as indicated by histopathological examination of their stomachs. The results indicate that both H. felis inoculation and/or stress activate C. muris and cause gastric inflammation. The extent of the activation of C. muris depends on the duration of the stress.

Animals↗