Biomedical subjects
Publications and source records attributed to G Haupt.
In kidney tumors arising from the collecting duct epithelium (Bellini duct carcinoma), histologic examination shows both tubular and papillary architecture, which can lead to misinterpretation as renal cell or transitional cell carcinoma. A case of multifocal bellini duct carcinoma is described, to the authors' knowledge the first to be reported.
During the last decades the influence of physical factors on fracture healing has been widely described. With the use of shock waves for the treatment of urolithiasis, a new mechanical medium has been introduced into medicine. For the first time the influence of shock waves on fracture healing was studied in rats. With fractioned shock-wave treatment (5 times 100 shock waves at 14 or 18 kV) an enhancement in healing could be achieved.
Primary carcinoma of the urethra in women is extremely rare and associated with non-specific symptoms of the lower urinary tract, the vagina and the pelvic floor. On the basis of four case reports, the frequent delay in diagnosis is presented and the therapeutic course is outlined.
During the last 20 years, the role of various physical factors in wound healing has been widely studied and recognized. With the use of shock waves for the treatment of urolithiasis, a new mechanical medium has been introduced into medicine. The influence of shock waves on the reepithelialization of partial-thickness wounds was studied in four Yorkshire piglets by a quantitative morphometric method. Wounds were inflicted either in intact skin (three pigs) or in skin irradiated with 1500 rads to achieve delayed healing. A significant enhancement in normal or delayed healing was found with low-dose treatment (10 SW at 14 kV). High-dose application of shock waves (100 SW at 18 kV) resulted in inhibition of the rate of reepithelialization of the wounds. Shock waves of intermediate energies were without effect. The stimulating effect of low-energy shock waves coincides with significantly increased vascularization of the upper dermis and thicker layer of the newly formed epithelial cells covering the wound.
We report a case of ileal neobladder rupture after radical cystectomy due to mucus obstruction of the bladder neck. Since mucus production in bowel neobladders cannot be sufficiently influenced pharmacologically, patients with a continent urinary diversion connected to the urethra should learn self-catheterization.
Correlation between neu/c-erbB-2/Her-2 gene amplification and overexpression of the neu gene product has been reported in tumors of glandular origin, especially ductal breast carcinomas. Formalin-fixed and dewaxed sections from 23 cases of mammary (MPD) and 9 cases of extramammary (EPD) Paget's disease were immunohistochemically stained by means of the monoclonal antibody 3B5 directed against an intracellular domain of the neu gene protein. All MPDs exhibited a distinct membrane staining of tumor cells independent of the presence of ductal breast carcinomas found in 18 cases. All these breast carcinomas also were positive for neu staining. In contrast to MPD, all EPDs were negative. Normal epidermis was always negative. Northern blot analysis sustained the immunohistologic findings in that the presence of neu mRNA could be demonstrated in two of three cases with MPD. Negativity in one case was due to dilution effects by nontumor cells. Our results suggest that Paget cells of mammary and extramammary localization, although very similar phenotypically, derive from different genetic accidents. Furthermore neu positivity in all MPDs and all underlying ductal carcinomas suggests common genetic alterations for both tumors. However the finding of five neu protein-positive MPDs without associated ductal breast carcinomas may suggest a somewhat different transformation process.
Since the inception of extracorporeal shock wave lithotripsy 9 years ago treatment strategies have changed. Patients currently are receiving larger numbers of higher voltage shock waves. However, upper limits of safety for these treatments have not been established. In an attempt to address this question a comparative study of effects of extracorporeal shock wave lithotripsy on laboratory values between 2 stone centers, Munich and Tucson, using different treatment strategies 3 to 4 years apart was done to identify possible differing effects. Patient stone burdens were similar. However, Tucson patients received almost twice the number of shock waves. Both groups showed a significant decrease in hematocrit (by 8.7 per cent in Munich and 6.4 per cent in Tucson). Both groups had a significant increase in white blood count (14.5 per cent in Munich and 22.7 per cent in Tucson). In addition, both groups had increased serum levels of glutamic oxaloacetic transaminase of 43.3 and 59.7 per cent, respectively. However, only the Tucson group showed increases in serum glutamic pyruvic transaminase, lactic dehydrogenase and total bilirubin in 51.5, 40.8 and 46 per cent of the patients, respectively. Further analysis indicated that extracorporeal shock wave lithotripsy was associated with 2 significant short-term changes of blood or serum laboratory values: 1) those presumed to be dilutional from related infusions, rather than extracorporeal shock wave lithotripsy treatments themselves and 2) those presumed to be related to cellular injury after high energy treatments. Elevated serum glutamic pyruvic transaminase, lactic dehydrogenase and total bilirubin values of Tucson patients clearly were related to higher kilovolts and number of shocks or to treatments on the right side.(ABSTRACT TRUNCATED AT 250 WORDS)
Several permanent cardiac pacing techniques have been utilized to control resistant cardiac arrhythmias. SA block, sinus arrest and intermittent ventricular tachycardia was controlled by the use of an atrial 'J' catheter and a rate programmable demand pacemaker. When these arrhythmias were associated with AV conduction delay they were managed with an AV sequential pacemaker with the additional insertion of a ventricular pacing lead. Appropriate adjustment of the AV sequential interval inhibited reciprocal AV or VA reentry thus controlling reciprocal tachycardia. Frequent ventricular premature systoles or intermittent ventricular tachycardia with in appropriately delayed sinus or subsidiary escape cycle lengths appear best managed by an AV sequential pacemaker by adjusting the atrial return cycle. Intractable atrial reentry tachycardias appear best managed by paired or rapid atrial stimulating pacemakers. Development of variable atrial rate, AV sequential and atrial return cycle activating pacemakers offer an effective control of resistant cardiac arrhythmias.