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Biomedical subjects

G Heidbreder

Publications and source records attributed to G Heidbreder.

7 recordsLinked to original sources
PubMed1980

[Acrobullous photodermatitis caused by PUVA: measurement of dermo-epidermal adhesion].

In 65 patients suffering from psoriasis treated with photochemotherapy and 32 healthy controls the dermo-epidermal junction was measured by experimental blistering. A significantly shortened blistering time was shown in PUVA-patients. The reasons in discussion are the increase of activated melanocytes (clear cells) in the basal membrane region and changes in the connective tissue by long term PUVA-therapy.

Adult↗
PubMed1979

Therapy of psoriasis with retinoid plus PUVA: clinical and histologic data.

In a group of 40 patients suffering from wide-spread psoriasis oral administration of a retinoid (Ro 10-9359) was followed by PUVA therapy. The clearance rate was increased by 30% as compared to PUVA alone. Except for cheilitis no side effects were seen. Histological analysis in 20 patients before, during and after therapy revealed an intensification of psoriatic tissue changes after retinoid treatment. Loss of corneal layers, massive exoserosis, and neutrophil migration were prominent features. Mitotic counts were not increased by the pretreatment. The increased susceptibility of diseased skin to PUVA as produced by this drug appears to be based on several factors related to the tissue changes revealed by histology.

Humans↗