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Biomedical subjects

G Helbing

Publications and source records attributed to G Helbing.

31 records · Page 2Linked to original sources
PubMed1979

[In vitro study of isolated chondrocytes concerning the prognosis of transplanted cartilage].

In order to find out reliable criteria to conclude on the prognosis of transplanted cartilage the quality of isolated rabbit chondrocytes was assayed in vitro. Using a semisolid medium a culture system is introduced, which is able to detect colony forming units of chondrocytes. Furthermore their proliferative and differentiating capacity was investigated. Colony formation in vitro follows a strict dose response relationship. An inverse relationship was observed between the age of the donor and the colony incidence in vitro. Cells from neonatal cartilage could be induced to grow as fibroblastic colonies in the presence of conditioned medium from fibroblastic monolayer cultures. No effect, however, could be observed with chondrocyte derived conditioned medium.

Age Factors↗
PubMed1978

[Stability after obtaining cancellous bone from the greater trochanter].

To test the endangered stability after obtaining cancellous bone from the greater trochanter, the ultimate breaking force of 40 human femura was measured with a material testing machine (Instron 1115). 1. 10 Femura after removing bone from the greater trochanter as a routine clinical procedure showed a significantly reduced trochanteric stability (p less than 0.05), 4 subtrochanteric and 3 pertrochanteric fractures, compared to 10 intact opposite femura with vertical shear fractures of femural neck and head without damage to the trochanteric region. 2. The number of fractures crossing the window was reduced by half, p less than 0.05 when a round cortical window compared to when a square window of the same area was cut. As the reduced stability caused by the remove of cancellous bone can not be avoided, we can clearly reduce the danger of stress concentration in the notches by cutting a round corticalis window. Cancellous bone from the greater trochanter should only used, if it cannot be taken from the brim or posterior iliac spine of the pelvis.

Biomechanical Phenomena↗
PubMed1978

[In vitro culture system for the characterization of growth potential of cartilage transplants].

In order to find reliable criteria for determining the prognosis of transplanted cartilage, the quality of isolated rabbit chondrocytes was assayed in vitro. A culture system of semisolid medium was able to detect colony-forming units of chondrocytes. Also their proliferative and differentiating capacity could be investigated. Colony formation in vitro follows a strict dose-response relationship. An inverse relationship was observed between age of the donor and the colony incidence in vitro. Cells from neonatal cartilage could be induced to grow as fibroblastic colonies in the presence of conditioned medium from fibroblastic monolayer cultures. No effect, however, could be observed with chondrocyte-derived conditioned medium.

Age Factors↗
PubMed1977

[Management of ligamentous knee injuries (author's transl)].

Injury to ligaments, which will eventually result in knee instability, requires operative treatment when the radiologic tilt exceeds 3 degrees. Therapy comprises anatomic reconstruction of the capsule, ligaments, and menisci. Postoperatively, a hinge cast (limited motion cast = LMC) is applied; a range of motion of 40 degrees does not endanger stability. Excellent subjective results were found in 90% of 80 cases with acute ligamentous lesion upon follow-up examination; 77 patients returned to work after an average of 5.3 weeks after removal of the LMC; range of motion was satisfactory with full stability in 69 patients.

Animals↗
PubMed1977

[Knee-ligaments--operation and functional postoperative care (author's transl)].

After surgical repair of ruptured knee-ligaments the patients have a functional treatment with the help of a limited-mobilization cast (LMC). Flexion from 20 to 60 degrees exerts no tension on the knee-ligaments. Damage to the cartilage by immobilisation can be prevented, the frequency of post-traumatic arthrosis reduced.

Casts, Surgical↗