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Biomedical subjects

G Helmius

Publications and source records attributed to G Helmius.

29 records · Page 2Linked to original sources
PubMed1980

Coronary by-pass operation--graft and left ventricular function.

Of 121 patients surviving a by-pass operation 114 have been folowed up hitherto. At first follow-up - usually one year after operation - the angina pectoris was relieved in 87% of the patients and in 85% at least one vein by-pass was patent. A high correlation was found between subjective result and graft patency. Advanced arterial changes at preoperative coronary angiography did not prevent good result after surgery. In about half of the patients whose pain was relieved, the left ventricular ejection fraction was increased postoperatively. However, in many patients, who were subjectively improved, the ejection fraction was unchanged or even decreased.

Adult↗
PubMed1980

Myocardial infarction without coronary occlusion. A study with a new experimental method in sheep.

An experimental method for induction of myocardial infarction in sheep is described. This leads to local infarction without arteriographically demonstrable lesions in the coronary arteries. A 0.95 mm thick thermosonde is introduced into a coronary artery through a catheter. The tip of the thermosonde is heated to 45-65 degrees C for 1-2 min and the thermosonde is then removed. On heating of the tip, infarction occurs instantaneously, as observed both macro- and microscopically and at left ventricular angiography. The thermosonde method described makes it possible to induce myocardial infarction in sheep in a reproducible way and is therefore applicable to studies of the pathogenesis of infarction. This justifies its use in investigations of the effect of myocardial infarction on the anatomy and function of the left ventricle and coronary arteries.

Angiography↗
PubMedDate not supplied

Repeat femoral arteriography in hyperlipidemic patients. A study of progression and regression of atherosclerosis.

Femoral arteriography was performed in 62 patients with significant hyperlipidemia. Sixty were asymptomatic and two had intermittent claudication. The patients participated in a study aiming to demonstrate whether serum lipid lowering by drugs could influence the development of femoral artery atheromatous disease. Half of the patients were treated with fenofibrate and nicotinic acid and the other half served as a control group. At the first arteriography atherosclerotic lesions were found in 46 of the 62 patients (74%). Arteriography was repeated up to three times without complication. Visual analysis of angiograms revealed considerable inter-observer variation. An attempt was made to assess the angiograms by a computerized method which, however, still needs improvement and a computer designed for image analysis. Most patients had small or moderate atheromatous deposits in the femoral artery at the initial examination, in most cases showing no change during the study period of 18 months. Regression was found in five patients of the treated group, but in none of the control patients as judged by visual gradation (p less than 0.001).

Adult↗
PubMedDate not supplied

Quantitation of atherosclerosis in femoral arteriography with ECG gated exposures.

Using a densitometric method introduced in 1977 by Crawford et coll. the volumes of segments of the femoral artery were calculated from two angiographic series in each of 13 patients. ECG gated exposures were used to minimise the error of the method. The reproducibility of the method was found to be better than in a previous study in which ECG gating was not used. The method may therefore be of use in long term angiographic follow-up studies of atherosclerotic lesions, although the impact of different investigation parameters on methodologic precision is still not fully known.

Arteriosclerosis↗