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Biomedical subjects

G Hinz

Publications and source records attributed to G Hinz.

At least 19 recordsLinked to original sources
PubMed1991

[The behavior of substance P concentration in rat plasma in the acute single- and combined-actions of trichloroethylene and ethanol].

In experimental studies in male Wistar-rats exerted for determination of trichloroethylene, ethanol and combined action influences on the substance P plasma concentrations. These concentrations were determined by a radioimmunological method. The acute exposure of trichloroethylene and ethanol lead to a significant rise of substance P. We found high substance P concentration peaks, in principle, 4 h after acute exposure and the combined action shows the greatest effect.

Animals↗
PubMed1978

Apparent effects of neurotransmitters on sexual differentiation of the brain without mediation of sex hormones.

Male sexual behaviour was found to be permanently decreased in neonatally reserpinized or paragylinized male rats. On the other hand, hypoplasia of sex organs was only observed in reserpinized, but not in pargylinized newborn males. Furthermore, male sexual behavior was found to be permanently increased in neonatally pyridostigminized males which showed even a slight hypoplasia of seminal vesicles in neonatal life. These findings suggest that changes of neurotransmitter concentrations and/or turnover rates apparently induced by psychotrophic drugs can affect sex-specific brain differentiation by direct action without mediation of sex hormones. Hence, neurotransmitters may be regarded as organizers of the brain.

Animals↗
PubMed1977

[Significance of body weight in degenerative skeletal diseases (author's transl)].

An attempt was made to ascertain the influence of body weight on degenerative skeletal diseases in a group of 250 hospitalized patients suffering from gonarthrosis and/or lumbar syndrome. The current average body weight according to age, size and sex (Geigy Tables) were used as the standard. Patients with gonarthrosis were significantly overweight while patients with lumbar syndrome fell within the normal range. A prearthrosis or prearthritic deformity of the vertebral column or knee could be demonstrated in the majority of patients, particularly the younger ones. In most of the older patients, an age-induced reduction in the quality of cartilage and tissue of the intervertebral disk was already present. For the established casual significance of prearthroses, the only possible influence of body weight on the development of alterations is as a contributing factor, to functional strain. A statement cannot be made concerning the importance of this contributing factor for methodological reasons; an essential influence, however, is doubtful. Overweight alone does not tend to induce degenerative skeletal alterations under normal static and occupational conditions.

Adult↗
PubMed1977

[Trial of piracetam in children with cerebral organic mental deficiency].

The administration, in a double blind experiment, of piracetam to two homogeneous groups of 32 and 34 eight- to twelve-year-old brain-injured special education children lacking normal mental ability, where the daily doses administered for a period of thirteen weeks were 3 tablets or 1.2 g (administered to second and third graders) and 5 tablets or 2.0 g (administered to fourth graders), respectively, did not produce a lasting effect upon the capacity to acquire and apply knowledge, the concentration power, the proficiency level, and the behavior shown by pupils during and out of school hours. On the other hand, there was observed, in patients receiving placebos, a nonsignificant tendency toward improvement in physical well-being, so that the effect produced by the drug may here be considered to be a negative one.

Attention↗
PubMed1976

[Influence of prenatal malnutrition on later body-weight gain in guinea pigs].

In prenatally underfed guinea pigs the following data were obtained: 1. On the 1st day of life the mean body weight of 18 underfed animals was significantly reduced as compared to that of 18 control animals. This difference was not compensated by postnatal feeding ad libitum but persisted up to the 36th week of life (day of sacrificing). 2. The mean food intake per day estimated over 10 days during the 5th month of life was also significantly diminished in the prenatally underfed animals. 3. A significant positive correlation was found between the body weight at birth and the adult body weight, adult body length and adult body weight/body length, when the parameters of the experimental plus control animals were evaluated together. These findings suggest that in guinea pigs, which are born in a relatively mature stage, the prenatal nutrition can influence body weight, body length and body weight/body length ratio as well as food intake in adulthood.

Animals↗
PubMed1976

Teratopsychogenetic effects apparently produced by nonphysiological neurotransmitter concentrations during brain differentiation.

In male rats treated with pargyline, reserpine or pyridostigmine during neonatal life significant permanent changes of sexual behaviour and conditioned learning behaviour were observed in juvenile and/or adult life. Male sexual activity and learning capacity were permanently decreased in neonatally pargyline- or reserpine-treated animals, but permanently increased in neonatally pyridostigmine-treated rats. These findings suggest that nonphysiological concentrations and/or turnover rates of neurotransmitters, if produced during a critical period of brain differentiation, are able to induce lifelond effective behavioural changes, i.e. teratopsychogenetic effects.

Animals↗
PubMed1976

[Reflex-dystrophic pseudo-arthritis or Sudeck syndrome (author's transl) ].

Local bone- and tissue dystrophies identical with Sudeck's syndrome and progressing in 3 stages are called reflex dystrophies. In the 1st and 2nd stages complete recovery is possible, in the 3rd stage only irreversible dysptrophic-ankylosing defect-healing. Etiologic significance of causal factors discussed is not certain. In, initially similar, inflammatory and rheumatic arthritis often only the further course and radiologic appearance provide a diagnosis. So far we have no desirable clear definition of reflex dystrophic conditions.

Adult↗
PubMed1975

Androgen dependent brain differentiation and life span.

Intact females without neonatal hormone treatment served as control animals. A second group of female rats received 1.25 mg testosterone propionate subcutaneously on the first day of life causing in these genetic females a male-type brain differentiation. Male rats orchidectomized on the 75th day of life served as male "control" animals, since there was no lack of androgen during the neonatal phase of brain organization. A fourth treatment group consisted of males which had been orchidectomized on the first day of life representing males with female-type differentiated brains. The experimental animals belonging to the Sprague-Dawley-derived strain of our laboratory were kept under standard conditions for food, illumination and temperature.

Androgens↗