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Biomedical subjects

G Hobbs

Publications and source records attributed to G Hobbs.

At least 37 records · Page 2Linked to original sources
PubMed1992

An integrated approach to studying regulation of production of the antibiotic methylenomycin by Streptomyces coelicolor A3(2).

A physiological and molecular biological study was made of the control of methylenomycin biosynthesis by Streptomyces coelicolor A3(2). A simple and reliable assay for this antibiotic was developed. Conditions that permit the synthesis of methylenomycin by S. coelicolor cultures grown in defined medium were elucidated: a readily assimilated carbon and nitrogen source is required. Under these conditions methylenomycin is produced late in the growth phase, at the time of transition from exponential to linear growth. Provided that the phosphate concentration in the medium is kept high, there is synthesis of methylenomycin but not of the other secondary metabolites that this strain can produce. These conditions were used to study the transcription of the methylenomycin gene cluster during the transition from primary to secondary metabolism. The biosynthetic genes of at least one of the mmy transcription units appear to be transcribed before the mmr resistance determinant. The possibility that methylenomycin induces the transcription of mmr is discussed.

Acetates↗
PubMed1989

Measuring outpatient satisfaction with rehabilitation services.

Rehabilitation Services Department staff at University Hospital-UBC site (Vancouver, British Columbia) conducted a patient satisfaction survey in 1987 to measure outpatient satisfaction with the care received. Fifty completed surveys, which represented approximately 10% of the outpatient population discharged during the study period, indicated that outpatients were primarily satisfied with the actual care and services provided and least satisfied with environmental factors, such as parking, waiting area conditions, and directions to treatment facility.

Adolescent↗
PubMed1988

Food poisoning due to the consumption of red whelks (Neptunea antiqua).

Two incidents of toxin-type food poisoning in N.E. Scotland associated with the consumption of red whelks (Neptunea antiqua) are described. Four patients developed symptoms within 1 h of consuming whole whelks. These included visual disturbances--double vision and difficulty in focusing--tingling of the fingers, prostration and in one subject nausea, vomiting, diarrhoea and ataxia. In all cases recovery was complete in 24 h. Using a newly developed analytical technique the concentration of the causative toxin, tetramine, in the salivary glands of the whelks consumed was estimated at 0.07%, equivalent to a content of 3.75 mg/100 g of the shellfish.

Adult↗
PubMed1982

Scombrotoxin and scombrotoxin-like poisoning from canned fish.

A number of scombrotoxin poisoning incidents which have recently occurred in the UK following the consumption of canned fish have been investigated. Symptoms are described and the relationship between the histamine content of incriminated samples and toxicity is discussed.

Animals↗
PubMed1980

Scombrotoxic fish poisoning: features of the first 50 incidents to be reported in Britain (1976-9).

Fifty incidents of scombrotoxic fish poisoning affecting nearly 200 people have been reported in Britain, the majority in 1979. Increased consumption of mackerel, inadequate storage conditions, and more general clinical recognition of the condition are considered responsible for the rise in outbreaks. Though the illness is generally not serious, it may be alarming and unpleasant and is totally preventable by proper attention to principles of hygiene at all stages of production, distribution, and storage.

Animals↗