Biomedical subjects

G Hold

Publications and source records attributed to G Hold.

7 recordsLinked to original sources

PubMed1995

Pulmonary oedema in healthy persons during scuba-diving and swimming.

The prevalence of pulmonary oedema during scuba-diving is unknown. In our referral centre for diving accidents we have observed several episodes of pulmonary oedema in four previously healthy persons while scuba-diving or swimming. Four events were documented by physical findings, typical chest radiographic changes, and arterial hypoxaemia. Four additional episodes were identified in one of the individuals by a suggestive history. No technical problems with the diving equipment were detectable and none of the individuals reported aspiration of water. In order to gather information about the incidence of pulmonary oedema, we carried out a survey among 1,250 divers. To elucidate possible underlying mechanisms of this complication we investigated forearm vascular resistance, levels of vasoreactive hormones, and left ventricular function by Doppler echocardiography, at room temperature and during cold exposure, in four patients and in healthy control subjects. We found only one additional person with a history suggestive of pulmonary oedema among 460 responders to the survey. We found no differences in forearm vascular resistance, left ventricular systolic and diastolic function, and plasma levels of epinephrine, norepinephrine, cortisol, aldosterone, renin and atrial natriuretic peptide between the patients with a history of pulmonary oedema and the control subjects. We conclude that the occurrence of pulmonary oedema during scuba-diving or swimming is an extremely rare event in healthy individuals. The mechanisms responsible remain unclear.

Adult↗

PubMed1993

[Antibiotic-resistant pneumonia].

A 77-year-old lady with malaise, cough, weight loss, an elevated ESR and bilateral patchy infiltrates on the chest X-ray is described. The symptoms progressed inspite of antibiotic treatment. On the basis of clinical findings, transbronchial biopsy, bronchoalveolar lavage and lung function tests the diagnosis of a bronchiolitis obliterans, organizing pneumonia (BOOP) was established. The clinicopathological entity of BOOP, its differential diagnosis and treatment are discussed.

Aged↗

PubMed1993

[Febrile status and micronodular changes of the lung parenchyma in HIV infection].

This 49-year-old man with the acquired immunodeficiency syndrome (AIDS) was admitted to the hospital because of fever, weight loss and respiratory symptoms. The radiograph of the chest showed diffuse fine nodular opacities. Histology of lung and lymph node revealed a necrotising granulomatosis and yeasts suggesting histoplasmosis. It's identity was confirmed by positive cultures for Histoplasma capsulatum in blood, urine, lung specimen and lymph node. There was a successful induction treatment and a maintenance therapy with amphotericin B. We discuss disseminated histoplasmosis in the immunodeficiency syndrome.

AIDS-Related Opportunistic Infections↗

PubMed1993

[Thoracic pain].

A 28-year-old male patient was admitted to our outpatient clinic because of severe chest pain. Past history, ECG and laboratory findings revealed an anterior myocardial infarction and rhabdomyolysis after cocaine consumption. Coronary arteriography performed six days after the infarction showed no significant stenoses. In view of these findings a coronary vasospasm due to cocaine was postulated. Cocaine effects are discussed.

Acute Disease↗

PubMed1992

[Pulmonary changes in ulcerative colitis].

We report on a 54-year-old patient who developed symptoms of bronchitis 3 months after colectomy for ulcerative colitis. Bronchiectases were documented by high resolution computer lung scan. Several cases of ulcerative colitis associated with alterations of the airways, of the pulmonary parenchyma, of the lung vessels and of the pleura have been published. Symptoms of bronchitis, often on the basis of bronchiectases, are the most commonly observed pulmonary problems in this inflammatory bowel disease. Furthermore, abnormal pulmonary functions have been found even in asymptomatic patients. Our patient was treated with oral and topical corticosteroids. The symptoms disappeared and pulmonary function returned to normal.

Adrenal Cortex Hormones↗

PubMed1992

Diagnostic value of hemosiderin-containing macrophages in bronchoalveolar lavage.

STUDY OBJECTIVE: Our objective was to determine if the hemosiderin content of BAL macrophages allows us to draw any differential diagnostic conclusions in a variety of lung diseases. PATIENTS AND STUDY DESIGN: One hundred one patients who underwent BAL for different diagnostic reasons were studied prospectively. MAIN RESULTS: The highest values for the hemosiderin score (HS) were found in patients with active alveolar hemorrhage and patients who had undergone heart transplantation for congestive heart failure. Compared to a control population, patients with Pneumocystis carinii pneumonia or invasive aspergillosis had a higher HS than patients with bacterial pneumonia or mycobacterial lung infection. High or intermediate values for HS were more often found in patients with a low than in those with a normal platelet count. CONCLUSIONS: The differential diagnostic conclusions which can be based on an HS are limited.

Adolescent↗

PubMed1982

[Epiphysiolysis of the distal tibia. Treatment and results].

23 patients with traumatic epiphyseolysis of the distal tibia with and without additional metaphysical fragment have been seen at the Surgical Department of the University Children's Hospital, Zurich. 21 were treated conservatively, only 2 were operated upon. 21 of the 23 children were found for follow-up 2 to 11 years, mean 6 years after trauma. 15 were well and without any clinical symptoms, 6 had occasional slight pains with changing weather etc. Clinical examination was normal in all patients. 4 had axial malposition of more than 8 degrees at X-ray control. One patient with additional periostal interposition had an early epiphyseal closure and needed therefore an epiphyseodesis of the contralateral distal tibia. None of the 21 patients had more than 10 mm difference in length compared with the non-injured leg. Our late results confirm that in cases of traumatic epiphyseolysis, the conservative way is usually the treatment of choice.

Adolescent↗