Biomedical subjects
Publications and source records attributed to G Holub.
This report deals with a female patient with Wegener's granulomatosis, exhibiting characteristic asymptomatic lung disease and palpable purpura but also a granulomatous vasculitis of the intestine which led to multiple perforations. Therapy with cyclophosphamide and corticosteroids brought remission of all lesions.
Plasma prolactin was measured in 10 patients with prostatic cancer during treatment with cyproterone acetate (300 mg/week i.m.) Prolactin was assayed during a six month period at weekly intervals during the first 4 weeks and then at monthly intervals. Orchiectomy was not carried out. After 6 months prolactin levels were elevated compared with pre-treatment levels. It is concluded from this study that cyproterone acetate interferes with prolactin secretion by the pituitary gland.
Over a period of four years 352 patients suspected of having a carcinoma of the prostate were investigated and 463 cytological and 343 histological examinations were undertaken. In 340 cases the cytological findings on transrectal aspiration biopsy according to Franzen [14] were compared with the histological findings on transperineal punch biopsy. This comparison showed an accuracy of 64.5% and if the PAP III findings were included, of 76.6% in diagnosing prostatic carcinoma by the cytological method. Since the majority of cases were first biopsies and a repeat biopsy was not made in view of the positive punch findings, the chances of detecting a carcinoma of the prostate by aspiration biopsy alone theoretically increase to almost 90%. The reasons for failures in concurrence of findings by the two methods are discussed.
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