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Biomedical subjects

G Hood

Publications and source records attributed to G Hood.

9 recordsLinked to original sources
PubMed1996

Ribosomal protein RL44 is encoded by two subfamilies in upland cotton (Gossypium hirsutum L.).

We have isolated 4 cDNA clones encoding the full-length sequence of the eukaryotic ribosomal protein RL44 from upland cotton (Gossypium hirsutum L.). Sequencing of these clones resulted in the classification of 2 subfamilies of RL44; these subfamilies had coding regions (315 bp) which were 92% identical. RL44-1 (454 bp) and RL44-2 (485 bp) constitute subfamily 1, whereas RL44-3 (913 bp) and RL44-5 (541 bp) constitute subfamily 2. The differences in nucleotide sequences, however, occurred only at third codon positions and the resulting amino acid sequences of the two RL44 subfamilies were identical. The ORF encoded a protein of 105 residues with a Mr = 12029. A bipartite nuclear targeting sequence was identified from residues 29 to 43.

Amino Acid Sequence↗
PubMed1994

Difficult intubation following thoracic trauma.

A previously fit 20-year-old man presented with a large haemothorax following a stab wound to the left chest. Pre-operative airway assessment indicated that tracheal intubation would be routine. On induction of anaesthesia, visualisation of the larynx proved impossible because of soft tissue swelling. Successful intubation was eventually achieved with the aid of a gum elastic bougie. At operation, the patient's common carotid artery was found to have been perforated close to its origin on the aorta. The patient made an uneventful recovery.

Adult↗
PubMed1991

Postoperative analgesia after triple nerve block for fractured neck of femur.

Fifty patients with fractured neck of femur that required surgical correction with either a compression screw or pin and plate device were randomly allocated to receive one of two anaesthetic techniques, general anaesthesia combined with either opioid supplementation or triple nerve block (three in one block) with subcostal nerve block. The nerve blocks significantly reduced the quantity of opioid administered after operation; 48% of these patients required no additional analgesia in the first 24 hours. Plasma prilocaine levels in these patients were well below the toxic threshold, and peak absorption occurred 20 minutes after the injection. No untoward sequelae were associated with the nerve blocks.

Aged↗
PubMed1984

Trophectoderm in control of murine embryonal carcinoma.

It has been shown previously that the intact blastocyst of the mouse can regulate tumor formation and colony formation of murine embryonal carcinoma. This effect is consistent with the close histogenetic correspondence between embryonal carcinoma and the inner cell mass of the blastocyst. The ability of inner cell mass, blastocele fluid, and inner and outer surfaces of trophectoderm to abrogate colony formation of a variety of malignant tumors has now been tested. Direct contact of the embryonal carcinoma cells with the blastocele surface of trophectoderm proved to be necessary for abrogation of colony formation of embryonal carcinoma. This effect was not seen with any of the other tumors tested. Some tumors, which lack a normal cellular counterpart in the blastocyst, grew poorly in the blastocele unless a fistula was made in the wall of the blastocyst. Colony formation of the embryonal carcinoma was regulated in blastocysts with fistulas, but the other tumors were not regulated under these conditions. It is concluded that colony formation of embryonal carcinoma cells is regulated by direct contact with the trophectoderm of its corresponding embryonic field in an unknown but specific manner.

Animals↗