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Biomedical subjects

G Hubmer

Publications and source records attributed to G Hubmer.

At least 19 recordsLinked to original sources

In situ extracorporeal shock wave lithotripsy of ureteral calculi with the MPL-9000X lithotriptor.

Within the wide armamentarium of urinary stone treatment modalities extracorporeal shock wave lithotripsy (ESWL) has been established as the first line procedure. With the Dornier MPL-9000X lithotriptor one has the choice of ultrasound or fluoroscopic localization of calculi throughout the entire urinary tract. Except for the kidney, ultrasound guidance is preferred for calculi in the distal ureter, while fluoroscopy is generally used on the proximal two-thirds of the ureter. Between January and December 1990, 123 ESWL treatments were performed on 83 patients suffering from ureteral calculi with an average stone size of 9.3 x 6 mm. Median treatment parameters were 1,597 shock waves at 19.3 kv. for 43 minutes. For stones in the upper two-thirds of the ureter sedation analgesia was given, while ESWL on the pelvic ureter did not create intolerable pain. Of the treatments 69% were done on an outpatient basis. In situ ESWL treatment of urinary calculi was successful in 72 patients (86.7%), and 20 patients (24.1%) were treated with multiple treatment sessions. ESWL therapy for 47 stones in the distal ureter showed better results than for 33 stones plus 2 steinstrasse in the proximal part (95.5% versus 80% stone-free rate). Of 4 patients with mid ureteral calculi 2 could be rendered stone-free by ESWL alone. Auxiliary procedures, such as percutaneous nephrostomy or ureteral splints, had to be performed in 15.7%. Final endoscopic stone extraction was done in 7 cases and open surgery in 4, constituting a 13.3% failure rate for ESWL therapy. The results prove that the MPL-9000X lithotriptor is effective for primary noninvasive stone treatment.

Combined Modality Therapy

[Renal cell carcinoma with venous invasion: therapy--prognosis].

Between 1966 and 1988 a total of 406 patients with renal cell carcinoma (RCC) was treated at our department. Among these 51 patients were found to have gross renal vein involvement, in 21 cases with extension into V. cava. In one case the tumor-thrombus has been reaching the level of the hepatic veins, in two cases the right atrium. MR and sonography, especially echocardiography, seems to be the best choice of diagnostics. Because of the advanced stage of disease only 21 patients were selected for operative treatment, in two cases under extracorporal circulation. Prognosis seems to be very poor, 11 patients (more than 50%) died within 2 years after diagnosis. But still the high risk and the great expense of tumor nephrectomy and thrombectomy in such cases, even with substitution of extracorporal circulation, seems to be justified by the actuarial 5-year survival rate of 20%.

Carcinoma, Renal Cell

Organ-preserving surgery for renal cell carcinoma in patients with a solitary kidney or bilateral tumors.

Organ-preserving surgery is generally accepted when renal cell carcinoma (RCC) occurs in a solitary kidney or in both kidneys. Over a 12-year period, 238 patients underwent surgery for RCC at our hospital; 15 (6.3%) of these underwent organ-preserving procedures. Nine of ten patients with disease in a solitary kidney are alive without evidence of tumor (four more than 5 years postoperatively and five from 2 to 4 years). Six patients had bilateral disease, three of whom are alive at 2, 2, and 3 years, and three of whom died at 4, 5, and 9 years.

Carcinoma, Renal Cell

[Ureteral obstruction caused by a grenade splinter].

It is reported on a 59-year-old patient who towards the end of the Second World War suffered a shell-splinter injury and was admitted to hospital under the picture of an acute ureteric obstruction with pyonephrosis 40 years after the event. One year after the operative removal of the obstructing shell-splinter again normal contrast medium excretion of the kidney affected and subjective symptom-free state of the patient. The symptom-free interval of 4 decades is remarkable. The difficulties of the establishment of the primary diagnosis as well as possible early and late complications of bullet and splinter injuries of the urinary tract are discussed.

Foreign Bodies

[Advances in the surgical treatment of renal calculi (author's transl)].

The most important advances in the surgical management of renal calculi are reviewed and the following current concepts are discussed: operation of the kidney in situ with dorsal muscle-sparing lumbotomy; intrasinusal pyelolithotomy as a modern principle of stone surgery; modern techniques for the localization and removal of stones from the renal pelvis (X-ray, ultrasound, coagulum pyelotomy); methods of hypothermal kidney preservation and operative techniques for staghorn calculi; and modes of surgical stone prophylaxis.

Humans

Prostatectomy with a no-catheter technique.

A method of no-catheter prostatectomy is described and the results of 350 operations are presented. It has been demonstrated that this method of prostatectomy can be done aseptically.

Humans

Direct vision urethrotomy in the management of urethral strictures.

A series of 32 patients underwent direct vision urethrotomy. The technique is simple and the stay in hospital short. Intra- and postoperative complications are rare. Postoperatively, a silicon catheter is left for approximately 7 days, then hydraulic self-dilatation is performed by the patient for 6 months. 25 patients in this series (83%) voided satisfactorily after the procedure and needed no further treatment. Unsatisfactory results were obtained in patients with long strictures, in traumatic strictures with large scarred areas and in patients who failed to carry out regular hydraulic self-dilatation. We advise direct-vision urethrotomy as a treatment of choice for urethral strictures which do not exceed a length of 3 cm.

Adolescent

[Surgical treatment of wilms' tumour and neuroblastoma with particular reference to staging (author's transl)].

Combined surgical, irradiation and cytostatic therapy has considerably improved the outlook in cases of Wilms' tumour over the past years. Unfortunately the therapeautic results in neuroblastoma have not shown improvement to the same extent. Staging of the tumour is an essential basis for thee establishment of optimum therapeutic management and prognosis. Further improvement in results could be achieved with enhanced early diagnosis of these tumours and centralized treatment in centres with requisite specialist teams.

Age Factors

[Diagnostic problems in massive adrenal haemorrhage in the newborn (author's transl)].

Massive adrenal haemorrhage in the newborn frequently presents as an abdominal mass and is difficult to diagnose when this is the sole clinical feature. Surgery is indicated for the diagnosis and treatment of those cases in which a malignant tumour cannot be ruled out from the X-ray appearance with certainty. 3 cases are discussed in respect to clinical signs and the differential diagnosis of adrenal calcification in infancy is briefly mentioned in this connexion.

Adrenal Gland Diseases

[Histological findings of the ureteropelvic junction in congenital hydronephrosis (author's transl)].

Histological investigation of ureteropelvic junction (UPJ) specimens of 21 patients with congenital hydronephrosis revealed in 7 instances pathological changes, which might be responsible for the obstruction. In 15 cases a significant increase of collagenous tissue within the UPJ, along with a relative deficiency of monocytes was noted. Each of the smooth muscle fibers was surrounded by fibrous tissue, which caused interruption of the "nexus" function and therefore loss of muscle contractions. The inability of normal muscle contractions within the UPJ might be a contributing factor to the pathogenesis of congenital hydronephrosis.

Adolescent