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Biomedical subjects

G Huffmann

Publications and source records attributed to G Huffmann.

At least 37 records · Page 2Linked to original sources
PubMed1977

[Electromyographic studies on the effect of the cinnamamide derivative LCB-29 in spastic syndromes (author's transl)].

In ten patients with para- or tetraspastic syndromes of various etiology 5 different spastic phenomena demonstrating pathologically raised excitability of muscle regulation functions were registered electromyographically before and 1 h after i.v. administration of N-(hydroxy-2-ethyl)-cinnamamide (LCB-29). In the majority of cases a marked decrease of spasticity was registered. The rapid onset of this effect of LCB-29 allowed constant test conditions and therefore eliminated other influences on spasticity. The decrease of raised polysynaptic excitability at spinal level led, at least in part, to the assumption of a spinal site of action of LCB-29. The absence of a sedative effect with oral medication makes a strong central effect seem less probable.

Adult↗
PubMed1976

[Motoricity in the aging human (author's transl)].

Every period of human life is accompanied by its own motoricity. Apart from spastic, extrapyramidal and cerebellar disturbances resulting from various types of diseases of middle and old age, the individual associated movements in miming and gesture become unharmonious and stiffer with increasing age and the hyperkinesia which was hidden by combined motoricity becomes more marked. Occasionally even a pronounced decline of motor efficiency occurs with apraxia, abasia and astasia. Then the psychic performance is usually similarly altered at the same time.

Aged↗
PubMed1976

[N. interosseous anterior syndrome. Study in 4 cases of our own and in 49 cases from the literature (author's transl)].

The anterior interosseous nerve branches off from the median nerve distal of the pronator radii teres. It lies on the interosseous membrane, always innervates the flexor pollicis longus, usually the portion of the deep flexor belonging to the second, sometimes also the portion belonging to the third finger, then runs to the pronator quandratus. In 4 cases of our own and in 49 cases from the literature we could show that an isolated lesion of the motor division of the median nerve has been seen after fractures and in connection with dull traumas, unusual activities, pressure and medical procedures. A mechanical origin can be assumed also in the so-called "spontaneous" cases of paresis without any indication of exogenous influence. It is described twice as often on the right as on the left side and in 15 of 17 cases of operative revision fascial bands, adhesions, and similar compressions were found. Frequently, the only sign of the syndrome is paresis of the flexor pollicis longus. The diagnosis becomes clearer, when the flexor digitorum profundus is also affected, since the extension of the first two or three end phalanges during flexion of all fingers constitutes a characteristic clinical feature. Occasionally, pain is present on the outside of the forearm, and this can lead to differential diagnostic reflections. In spite of the convincing operative findings we find that the experience to date is not sufficient to give a general recommendation for operative treatment. The prognosis is favorable, apparently even without operative revision; in some cases, however, as in one of our patients, the paresis does not improve until the second year after onset.

Adult↗
PubMed1976

[Brachial plexus injuries caused by motor-cycle accidents- catamneses (author's transl)].

During the last eight years we examined 45 patients, mostly juvenile, with brachial plexus injuries arising from motor-cycle and moped accidents. The neurological findings, radiological picture on the myelogramme, sanguineous fluid, different electrodiagnostic examinations and sweat secretion tests provided information on the location of the lesion and the defects to be expected at a later date. However, no method permitted determination of the total extent of the damage. In some cases we observed partial, oftern considerable improvement even in the second and third post-accidential years. Follow-up studies showed the significance of the personality structure as well as social conditions with respect to vocational rehabilitation, and the danger of early resignation. Consequently, rehabilitation efforts should start immediately after the healing of the initially incurred injuries.

Accidents, Traffic↗
PubMed1976

[Catamnestic studies of the value of vocational prognoses for persons with infantile brain-damage (author's transl)].

The basis of this study is the examination of 100 people who suffered from severe neurological and psychic defect syndromes. Of this group 49 were re-examined eight years later- age-range then 20 to 34. The vocational prognoses which were given at the first examination were determined according to the degree of severity of the disability and proved to be correct in 39 cases. In five cases each, the level of productivity was assessed either too high or too low. Only eleven of the sample group had an income exceeding DM 500,-45 were living either with their families or in institutions, and of the remaining four, who rented rooms, two were married. The course of life of this category of people, who suffers from such a wide range of disabilities, can be facilitated if attention is paid to the vocational prognosis before the individual starts vocational training.

Adult↗
PubMed1975

["Fatiguability" in myasthenic syndromes].

Neuromuscular disorders accompanied by a "myasthenic reaction", but without other symptoms of myasthenia gravis and no therapeutic response to cholinergic drugs may be called myasthenic syndromes. The abnormal fatigability can be shown in the electromyogram. Lasting voluntary contraction of a muscle shows a rarefication of the EMG-pattern. Sometimes during repetitive stimulation of the motor nerve a decrease in the amplitude of the muscle potential may occur. This decrease is poorly influenced by cholinergic drugs. Often this observation was present in patients with myositis and myotonic dystrophy, sometimes in other myopathies and seldom in neurogenic disorders. A failure in the neuromuscular transmission is discussed not only in myasthenia gravis, but also in myasthenic syndromes. But there may be another explanation. A decreased number of intact muscle fibers during lasting innervation will cause a more rapid fatigation of the muscle fibers and in this way there will be an exhaustion. It is discussed, whether the symptoms in myasthenic syndromes can be explained by an abnormal "fatigability".

Adolescent↗
PubMed1975

[Electromyography and electroneurography in peripheral facial nerve paralysis (author's transl)].

The function of the facial nerve can be examined by 4 electrodiagnostic methods. In the nerve excitability test and electroneurography the facial nerve itself is stimulated over the stylomastoid foramen, whereas chronaximetry and electromyography are performed in the muscles. In the majority of patients with Bell's palsy it is possible to make a more or less favourable prognosis by clinical examination alone. As soon as the paralysis is evident only these diagnostic tests give an accurate prediciton. The early realisation of a poor prognosis is surgically important. Chronaximetry and electromyography do not facilitate early assessment of the prognosis. The nerve excitability test and electroneurography can assist in the prognosis within the first 6 days after the onset. This is especially so with electroneurography, in which the muscle action potentials are examined during facial stimulation. A continual decrease of amplitude of the action potential of 50% in 2 days and a complete loss of potential in 4 to 6 days indicate a total nerve degeneration with an unfavourable prognosis.

Action Potentials↗