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Biomedical subjects

G I Grigor'ev

Publications and source records attributed to G I Grigor'ev.

13 recordsLinked to original sources
PubMed1999

[A method for atraumatic erythrocyte plasma removal to obtain membranes capable of performing the hemostatic function of thrombocytes].

A method for physiological hemoglobin elimination from erythrocytes is proposed. Its characteristic feature is increase of erythrocyte membrane permeability and complete release of hemoglobin from erythrocytes by adding an equal volume of 2% papaverin hydrochloride to washed erythrocyte suspension, followed by washing of empty erythrocyte membranes in isotonic sodium chloride solution. Clean intact erythrocytic membranes are obtained, possessing the hemostatic functions typical of blood platelets.

Adult↗
PubMed1995

["Sergeantella"--a morphological index of erythrodieresis or a result of degradation by fungi of the genus Paecilomyces].

The conception on fungal origin of sergentella-like elements in peripheral blood proposed by A. N. Dekhkan-Khodzhaeva et al. is discussed. According to the author, these elements are rather twisted coats of hemolyzed red cells. There is a close relationship between sergentellas and hemolysis activation in stress. It is suggested to count membranes of lyzed red cells in blood smears to rapidly diagnose latent hemolytic syndrome.

Erythrocyte Membrane↗
PubMed1987

[Experience with the clinical use of lithium oxybutyrate in patients with cardiac rhythm disorders].

An antiarrhythmic effect of lithium oxybutyrate was demonstrated in 81% of patients with ventricular extrasystole in the presence of affective disturbances, those with hypersympathicotonus in particular. In arrhythmic cases, lithium oxybutyrate was shown to have a hypokinetic effect on central hemodynamics and contribute to peripheral vasodilatation without causing clinically apparent circulatory disorders. The drug inhibits platelet aggregation and moderately increases blood procoagulation activity in the presence of greater erythrocyte deformability and improved bulbar conjunctival microcirculation.

Anti-Arrhythmia Agents↗
PubMed1978

[Importance of the thrombocytes and hemolytic syndrome in the pathogenesis of transient cerebral circulatory disorders in hypertension patients].

Study of the blood platelet functional activity and intensity of hemolysis in 41 patients with transient disorders of cerebral circulation and comparison of the results with the corresponding indices in healthy individuals, in 40 patients with hypertensive disease free of crisis, and in 25 patients with cerebral atherosclerosis led to the conclusion that the character of cerebral stroke is already determined in the pre-stroke period. It depends on the functional state of the blood platelets in many respects. In patients with hypertensive disease in a period clear of crisis, for instance, there is a tendency towards hypoaggregation possible associated with the presence of latent hemolysis. Platelet hypofunction progresses in the period of hypertensive encephalopathy and still more during its transformation into hemorrhagic stroke. On the contrary, in patients with atherosclerosis but no symptoms of cerebral ischemia the adhesion-aggregation activity of the platelets does not differ essentially from that in healthy individuals. With the development of signs of ischemia of the brain, the platelet activity grows considerably, particularly when transient cerebral circulatory disorders transform into ischemic stroke.

Blood Platelets↗
PubMedDate not supplied

[Effect of ethmozin and Ritmilen on microcirculatory hemostasis in patients with heart rhythm disorders].

Effects of ethmozine and ritmilen were studied in 75 patients with different disorders of cardiac rhythm predominantly proceeding in the form of extrasystole arrhythmia. The drugs were found to exert a distinct antiaggregant action on platelets and erythrocytes which was particularly pronounced at intravenous administration and transiently increased the number of leukocytes and their aggregation. A decrease of platelet aggregation was accompanied by an increase of their number and rejuvenascence of thrombocytogram. A marked antiarrhythmic effect was seen in 66% of patients, in the remaining patients cardiac extracontractions became more rare.

Adolescent↗