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Biomedical subjects

G I Khanina

Publications and source records attributed to G I Khanina.

5 recordsLinked to original sources
PubMedDate not supplied

[Efficacy of a preparation based on Lactobacillus acidophilus for protection from myelotoxic effects of ionizing radiation and antineoplastic cytostatics].

The ability of a Lactobacillus acidophilius (LA) based preparation to prevent from a myelotoxic damage was studied on (CBA.C57BL/6)F1 mice upon total gamma-irradiation or single intraperitoneal injection of cyclophosphan. The antitumor and antimetastatic activity of LA-based preparation was studied in experiments with C57BL/6 mice bearing Lewis lung carcinoma or melanoma B16. The preparation obtained from heat-killed Lactobacillus acidophilius species provides protection of hemopoietic stem cells, as evidenced by the amount of endogenous CFUs increased 3.4-6.7 times. The LA-based preparation favored accelerated overcoming the radiation- and cyclophosphan-induced leukopenia. At the same time, the drug did not affect the proliferative activity and apoptosis of tumor cells, their growth rate, and metastatic activity. Nor did it reduce the efficacy of the experimental tumor radiotherapy.

Animals↗
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[Medicinal capsules].

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Biopharmaceutics↗
PubMedDate not supplied

[The use of eubiotics for the treatment of bacterial vaginosis].

The study was concerned with the problem of the treatment of bacterial vaginosis. To correct the dysbiotic condition in the vagina, a two-stage procedure was applied. The first stage was aimed at the provision of the normal physiological condition of the vaginal medium and mucosa and the second stage was aimed at the provision of the normal microbiocenosis. At the second stage biological preparations such as lactobacterin, acylact, bifidumbacterin and bifidin were used. The recovery was stated in 88.4 per cent of the cases after a single treatment course with the use of the biological preparations. In 4.7 and 2.1 per cent of the cases the recovery was stated after two and three treatment courses respectively. In 4.7 per cent of the cases the treatment was of low efficacy. The use of the eubiotics for the treatment of bacterial vaginosis was shown to be highly efficient.

Adjuvants, Immunologic↗
PubMedDate not supplied

[Biological preparation based on Lactobacillus acidophilus, a new agent in the early treatment of combined radiation-thermal injuries].

Male mice F1 (CBA x C57BL6) were used for experiments. Animals were exposed to 7 Gy gamma-radiation and additionally inflicted to full-thickness thermal burn 10% body surface. As it has been revealed, single subcutaneous injection of the created biopreparation based on inactivated lactobacillus microbic biomass increased mice survival with combined injury from 23% to 73%. Therapeutic efficacy of this remedy did not correlate with postradiation damages of the hemopoietic system. Injection of killed L. acidophilus mixture strikingly averted development of the intestine autoinfection. Possible mechanisms of the benefit therapeutic action of the new preparation are discussed.

Animals↗