[Effect of preliminary administration of the synthetic antioxidant ionol on the contractile function of the heart during transitory ischemia and reperfusion].
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Biomedical subjects
Publications and source records attributed to G I Markovskaia.
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The effect of preliminary Na gamma-hydroxybutyric acid (GHBA) injection on the activation of adrenergic and hypophyseal-adrenal systems during emotional-painful stress and ulcerous affection of the stomach after the stress cessation was studied in experiments on rats. It was established that the preliminary GHBA administration inhibits stimulation of stress causing systems and thereby prevents ulcerous affection of the stomach mucosa. It is suggested that the activation of GHBA-ergic inhibiting system, which accompanies the stress, is a natural mechanism of limitation of the stress reaction and prevention of the stress affections.
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A comparison was conducted between the contractile function of the heart of hares and rabbits at rest and under isometric contractions regimens, and under such conditions the concentration of ATP and its breakdown products was studied in the myocardium of both species. It was demonstrated that the cardiac muscle of hares adapted by the evolution to the performance of intensive work does not possess any increased ability of developing systolic tensions, or any increased power of the ATP resynthesis apparatus. The advantage of such a heart-- its ability to pump an increased blood volume -- must be ensured by some different mechanism that requires still further investigations.
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