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Biomedical subjects

G I Sandle

Publications and source records attributed to G I Sandle.

61 records · Page 4Linked to original sources
PubMed1981

The effect of hydrocortisone on the transport of water, sodium, and glucose in the jejunum. Perfusion studies in normal subjects and patients with coeliac disease.

During perfusion of an isotonic solution containing 56 mmol/l glucose and 122 mmol/l sodium chloride, net movements of water and sodium and glucose absorption were measured in the absence and presence of intraluminal hydrocortisone along 20-cm segments of proximal jejunum in five normal subjects and five patients with active coeliac disease. In normal subjects, the mean net absorption of water and sodium was significantly increased in the presence of hydrocortisone decreased. In the coeliac patients, the mean net secretion of water and sodium was significantly decreased. In neither group was the effect of hydrocortisone associated with a significant increase in glucose absorption. Similar changes in net movements of water and sodium occurred in both groups, even though absorption of hydrocortisone in coeliac patients was 44% of the control value. These results suggest that hydrocortisone may have exerted a local effect on the mucosal transport of water and sodium.

Adult↗
PubMed1978

Pancreatic enzymes in human duodenal juice--a comparison of responses in secretin pancreozymin and Lundh Borgström tests.

We have compared the concentrations and total outputs of trypsin, amylase, and lipase secreted into the duodenum during secretin pancreozymin and Lundh Borgström tests in order to assess the relative intensity of pancreatic stimulation provided by these means. The mean concentration of trypsin, and the mean 10 minute total output of trypsin, amylase, and lipase after the meal (though less than the peak post-prandial responses) were equal to the respective peak enzyme responses after intravenous injection of 2 Crick Harper Raper units per kg of secretin Boots; and after intravenous injection of 2 Crick Harper Raper units per kg of pancreozymin Boots.

Amylases↗