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Biomedical subjects

G I Savitskiĭ

Publications and source records attributed to G I Savitskiĭ.

At least 19 recordsLinked to original sources
PubMed1988

[The immune status in variants of the course and outcome of acute delta virus infection].

The immune status was investigated in 32 patients with acute hepatitis of mixed etiology and in 39 HBsAg carriers, superinfected with delta virus. The relationship of changes in the immune status with a course and outcomes of acute delta virus infection was revealed. These changes returned to normal on patients with a cyclic course of disease, persisted in patients with a lingering process, and progressed in the development of subacute liver dystrophy. The most noticeable shifts (a decrease in all indices of the immune system) were revealed in patients with a fulminant course of disease.

Acute Disease↗
PubMed1987

[The outcome of viral hepatitis B and cellular immunity function].

Immunological examination of 158 patients with viral type B hepatitis (VH) was performed over time. Patients with HBsAg elimination for 60 days from the onset of jaundice and a favorable outcome of hepatitis at the height of the process demonstrated a decrease in the relative number of theophylline resistant lymphocytes (T-helpers), a decrease in theophylline sensitive lymphocytes (T-suppressors), an increase in the helper/suppressor (H/S) ratio up to 13.1/1 (the normal ratio being 3.9/1), a certain increase in the number of B-lymphocytes, activation of rosette-forming function of neutrophils, and a tendency to an increase in the activity of natural killer cells (NK). Patients with HBs-antigenemia over 60 days with subsequent convalescence also demonstrated similar changes of immunoregulating T-lymphocyte subpopulations but they developed later in relation to the onset of viral hepatitis. In the formation of chronic persistent hepatitis (CPH) there was no decrease in the absolute and relative number of T-suppressors from the onset of disease, the level of T-helpers and the H/S ratio were moderately lowered. Unlike CPH the suppression of the effector link of the immune system (phagocytosis and NK) and a decrease in the level of T-suppressors were noted in the development of chronic active hepatitis in all the periods of the process. The application of the above regularities to prognosis of VH outcomes, the choice and assessment of efficacy of immunocorrective therapy was discussed.

Adolescent↗
PubMed1984

[Possibilities of eradicating the persistent HBsAg carrier state].

Five HBsAg carriers were examined by clinical, biochemical, radionuclide, immunologic and histomorphologic methods. Different variants of structural and functional relations were established. Attempts were made to eradicate the persistent virus carrierstate with the aid of the antiviral drug virasol, the immunomodulating drug levamisole, nonspecific (BCG vaccine) and specific (original corpuscular vaccine against hepatitis B) immunostimulants. No positive therapeutic effect was obtained. The difficulties and possibilities of a further study into the title problem with due regard for integration mechanisms of infection and prospects of the effective prophylaxis of virus transmission from the mother to the child at birth are discussed.

Adult↗
PubMedDate not supplied

[Natural killers and interferon in complicated influenza and other acute respiratory viral diseases in children].

The results of the study on the functional activity of natural killers (NK) and serum interferon in 118 children ranging in age from 3 months to 5 years suffering from influenza and other acute respiratory viral diseases complicated with croup, pneumonia, and obstructive syndrome (66 children with influenza, 21 with parainfluenza, 16 with adenovirus infection, and 15 with respiratory syncytial virus diseases) are presented. The control group consisted of 22 normal children. Decreased NK activity was demonstrated in the acute period of all ARVD but was more marked in adenovirus disease and complications with pneumonia, bronchiolitis, obstructive syndrome. While in hospital, children with low interferon titres developed a new acute viral disease more frequently or their principal disease was complicated with pneumonia. The detection of NK cell inhibition in some patients with ARVD complicated with pneumonia, bronchiolitis and decreased serum interferon levels in these patients are considered as indications for administration of immunotherapy (levamisole, zixorin, cathergen).

Acute Disease↗
PubMedDate not supplied

[A study of the effect of thymotropin on immunologic indicators and excretion of virus in women with chronic cytomegalovirus infection].

Thymotropic hormone was given subcutaneously in a dose of 100 mg twice a week for 3 months to 10 women with verified chronic cytomegalovirus infection. After termination of the treatment, in 8 women the virus excretion was decreased and this was accompanied with some improvement in immunological parameters: increased activity of natural killers, enhanced interferon-producing activity of lymphocytes, higher theophylline-resistant lymphocytes, and lower theophylline-sensitive T-cells. The above results confirm the association between the activity of cytomegalovirus infection and the state of immunity and allow thymotropic hormone to be recommended for treatment of other groups of patients with cytomegalovirus infection.

Chronic Disease↗
PubMedDate not supplied

[Lymphocyte subpopulations in patients with viral hepatitis B and delta-infections].

Changes in subpopulations of T3, T4, T8, HNK-1, Ia-positive, B-IgM and B-IgG producing lymphocytes were studied in patients with acute and chronic active virus hepatitis B and delta infection. A decrease of T4-helpers/inducers was demonstrated in all the groups under study and of T3-lymphocytes only in patients with delta-hepatitis turning into liver cirrhosis. The number of suppressors/cytotoxic T8 cells increased and T4/T8 ratio decreased in most patients. The number of HNK-1, Ia-positive, B-IgM and B-IgG lymphocytes increased in many subjects examined. Most marked quantitative changes in lymphocyte subpopulations were observed in patients with severe forms of delta-hepatitis and with liver cirrhosis. Changes in lymphocyte subpopulations in patients with viral hepatitis B and delta-infection are explained by reconstruction of the immune system in response to infection, affection of lymphocytes with viruses and emergence of antilymphocyte antibodies.

Antigens, Viral↗
PubMedDate not supplied

[Indices of T-lymphocytes and their subpopulations in children with influenza].

The results of the study of T lymphocytes and their subpopulations in 150 children ranging in age from 2 months to 5 years suffering from influenza complicated with croup, pneumonia, and obstructive syndrome are presented. In 47 children, mixed infection: influenza with concomitant adenovirus infection or respiratory-syncytial infection was observed. The control group consisted of 22 normal children. In the acute period of influenza the number of T lymphocytes and their subpopulations was found to decrease. The greatest decrease in the levels of T lymphocytes and especially of E-theophylline-sensitive ones was observed in cases complicated with pneumonia and obstructive syndrome. In mixed infections, inhibition of E-RFC and their subpopulations was more marked in influenza and adenovirus disease. The data obtained by catamnestic observations of children with lowered levels of T lymphocytes suggest that such children should be referred to a risk group and apparently require immunocorrective therapy.

Adenovirus Infections, Human↗
PubMedDate not supplied

[Effect of levamisole on the course of chronic cytomegalovirus infection in women].

The therapeutic effect of orally given levamisole in the treatment of women with chronic cytomegalovirus infection was studied. The patients were examined serologically, cytologically, virologically; the factors of cell-mediated immunity were also studied. Oral therapy with levamisole resulted in a definite increase of the cell-mediated immunity with a trend for decrease in antibody titres and reduced virus excretion. Evaluation of the clinical effect of levamisole therapy, however, revealed no distinct difference in the outcomes of pregnancy in the groups of women treated or not treated with levamisole.

Adjuvants, Immunologic↗
PubMedDate not supplied

[Indices of cellular immunity in patients with influenza A1].

The content of T-lymphocytes was determined by the method of spontaneous rosette formation according to Bach et al. and of B-lympocytes by the method of complementary rosette formation according to Mendes et al. in patients with uncomplicated and complicated influenza A1. In the acute period the values of T-lymphocytes were low and of B-lymphocytes and "O" cells high. During the convalescent period the amount of T-lymphocytes became normal in most patients. In patients with concurrent chronic diseases and in elderly patients the amount of T-lymphocytes remained low for a longer period and did not become normal in most of them during convalescence. The amount of B-lymphocytes at the time of recovery remained high, but in patients with complicated forms of the diseases the values were higher.

Adolescent↗
PubMedDate not supplied

[Natural killer activity in influenza patients].

The activity of natural killers (NK) for K-562 target cells (human myeloleukemia cells) was determined in 20 patients with influenza complicated with pneumonia and in 11 patients with uncomplicated influenza. The influence of the autologous blood serum and recombinant alpha 2-interferon (reaferon) on NK activity was studied in vitro. In uncomplicated influenza, the activity of natural killers in the acute period of the disease was higher, and in patients with influenza complicated by pneumonia lower than in normal subjects. In the convalescent period, the activity of natural killers increased or approached the norm in complicated cases, and the average values showed no significant difference from those in normal subjects. The stimulating effect of the autologous blood serum and reaferon on the activity of natural killers in patients with complicated influenza was demonstrated in vitro.

Adolescent↗
PubMedDate not supplied

[Lymphocyte blast transformation to HBsAg and HBcAg in patients with various clinical forms of hepatitis B].

Sensitization of the peripheral blood lymphocytes to HBsAg and HBcAg in 51 patients with acute hepatitis B (HB) in the time course of infection, in 13 with chronic active hepatitis B (CAH) and 8 HBsAg carriers was studied by lymphocyte blastogenesis assay. In patients with mild or moderately severe forms of acute HB at the peak of the disease lymphocyte blastogenic response to HBcAg was observed; sensitization to HBsAg was lacking and could be detected only in the stage of convalescence when the specific response to HBcAg was already undetectable in most patients. No lymphocyte sensitization to HBsAg either at the peak of the disease or in convalescence was observed in patients with a lingering form of acute HB as well as in those with CAH and HBsAg carriers. At the peak of severe HB blastogenic response was demonstrated to both antigens under study but was more marked to HBcAg. Most patients with CAH showed lymphocyte blastogenic response to HBcAg. It is concluded that specific lymphocyte response to HBV antigens varies in relation to the severity and course of the infection.

Acute Disease↗