Observations on kidney damage in hamsters following a non-icterohaemorrhagic form of disease resulting from infection by Leptospira interrogans serotype icterohaemorrhagiae.
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Biomedical subjects
Publications and source records attributed to G I Twigg.
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One thousand two hundred and sixty-nine freeliving, wild mammals, representative of 16 species from estates in Berkshire, Oxfordshire and Surrey, were examined for the presence of salmonellas. Salmonella typhimurium was isolated from 1 and S. dublin from 7 house mice (Mus musculus). There were no isolations from the other species examined. It was concluded that the house-mice infected with S. dublin acquired the organism from experimentally infected cattle. The wild mammal population does not at present appear to constitute a reservior for infection of domestic animals.
Histological examination of 69 pairs of infected kidneys from 12 species of Rodentia, Lagomorpha, Carnivora and Insectivora revealed that leptospires were confined mainly to the proximal and distal convoluted tubule, were less often found in the thick loop of Henle and only rarely in the collecting duct. On no occasion were the organisms present in the thin loop of Henle. Preliminary observations on the relationship of leptospires to tubule epithelium indicate some degree of physical attachment. It is suggested that the avoidance of the thin loop of Henle might be a reflection of its structural properties.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.