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Biomedical subjects

G Iglesias Cubero

Publications and source records attributed to G Iglesias Cubero.

18 recordsLinked to original sources
PubMed2000

Left ventricular mass index and sports: the influence of different sports activities and arterial blood pressure.

BACKGROUND: The mechanisms by which endurance training produces physiological hypertrophy have been thoroughly investigated but not with young athletes. The aim of our study was to investigate arterial blood pressure exercise responses in young athletes who started heavy training by the age of 11, participating in metabolically different sports (cycling, kayaking, and soccer) and to analyse the influence that arterial blood pressure at maximum exercise and VO(2) max could have on the development of cardiac mass in these subjects. SUBJECTS AND METHODS: We studied a group of well trained normotensive male subjects, comprising 37 cyclists, 15 soccer players and 12 canoeists (mean age, 16+/-1 years). Evaluation included a clinical history and physical examination, M-mode and two-dimensional echocardiography, 12-lead resting electrocardiogram and a graded exercise test with direct determination of VO(2) max. Systolic and diastolic blood pressure were measured at rest and maximum exercise. Determination of the left ventricular mass index (LVMI) was performed using Devereux's formula with correction for the body surface area. RESULTS: Cyclists showed values of LVMI in g m(-2) significantly higher than those of other subjects (123 vs. 92 and 113). Canoeists showed the maximal arterial blood pressure at maximum exercise in mmHg (190 vs. 172 and 170) and cyclists showed the maximal VO(2) ml kg(-1) min(-1) uptake (57.6 vs. 48.5 and 53.3). A linear correlation was found between LVMI and VO(2) max (r=0.4727, P<0.001) and this correlation was also significant with systolic blood pressure at maximum exercise (r=0.2909, P<0.01). No differences in LVMI were found when comparing those subjects who presented systolic blood pressure at maximum exercise equal or greater than 195 mmHg with those who presented less than this value. CONCLUSIONS: It can be concluded that VO(2) max is the variable that better correlates with the LVMI. Athletes who reach greater systolic blood pressures at peak exercise have a tendency to develop greater LVMI. In comparison with soccer players and canoeists, cyclists are the sportsmen who develop a greater LVMI and VO(2) max.

Adolescent↗
PubMed2000

[Lipoprotein (a) as a predictor of severity of coronary artery stenosis documented by angiography in male coronary patients under 50 years old].

OBJECTIVE: To determine the relationship between lipoprotein (a) seric levels with the age of coronary artery disease debut and the severity of coronary lesions in a group of male patients less than 50 years old. PATIENTS AND METHODS: We studied a group of 230 male patients, younger than 50 who were consecutively admitted to the hospital because of an ischemic coronary event. During hospitalization, the lipoprotein (a) in plasma was measured in all patients. They were distributed in two groups according to age at time of coronary disease clinical presentation with a cut off age of 40. A group of 142 patients underwent a cardiac catheterism and coronariography due to clinical or electrical unstability. RESULTS: The lipoprotein (a) levels were related with the number of diseased vessels. In this way lipoprotein (a) levels were 12 mg/dl (1.5-75) in those patients showing a normal coronariography; 27 mg/dl (2. 5-96) in those with one vessel disease; 34 mg/dl (7-90) in those with two vessels affected and 63 mg/dl (2-116) in the case of three-vessel disease, with statistical significance of p = 0.003. No significant differences in lipoprotein (a) levels were found when the age of coronary artery disease presentation was taken into account. In this way lipoprotein (a) levels were 31 mg/dl (2-97) in patients younger than 40 years of age, in comparison to 33 mg/dl (2-94) in those older than 40. CONCLUSIONS: In our community male patients with a diagnosis of coronary artery disease and less than 50 years old showed a relationship between lipoprotein (a) levels and the severity and number of coronary vessel diseases. However, an association between lipoprotein (a) levels with the age of coronary disease presentation was not evident.

Adult↗
PubMed1999

[Acute myocardial infarction related to cocaine use].

Cocaine is a drug capable of potentiating the response to catecholamines. Acute myocardial infarction is the most frequently reported cardiac consequence of cocaine abuse, usually in those patients who had used cocaine in a habitual basis. We report a 30-year-old man, first-time cocaine user, that suffered an acute myocardial infarction.

Adult↗
PubMed1997

Primary amyloidosis and syncope.

A 59-year-old caucasian consulted our clinic with symptoms of dizziness and exertional syncope. The combination of myocardial hypertrophy diagnosed by echocardiography, together with a history of peripheral neuropathy made us suspect cardiac amyloidosis which was later proven by endomyocardial biopsy. A graded exercise test and two Holter monitoring studies revealed neither rhythm nor conduction abnormalities. A head-up tilt test revealed a vasovagal vasodepressor response.

Amyloidosis↗
PubMed1996

Variation in plasma lipid and lipoprotein concentrations in community-acquired pneumonia a six-month prospective study.

The nature of changes in the lipid profile caused by an acute infection is controversial. The aims of the present study were to study the changes in plasma lipids and lipoproteins in community-acquired pneumonia, to determine whether these changes differ according to the aetiologica/agents, and finally to observe the behaviour of these lipoproteins six months later. Sixty patients, aged between 18 and 87 years, admitted during the period September 1992 and April 1993 with suspected community-acquired pneumonia, were included in the study. Fifty-three of the patients completed the 15-day follow-up investigation, and 37 remained available for study for up to 6 months. On admission and at 15 and 180 days, analyses were carried out for total cholesterol, HDL cholesterol, apolipoproteins A1 and B, triacylglycerols and transaminases. Student's t test for parametric variables was used for statistical analysis, and the Mann-Whitney test for non-parametric variables. The concentrations of total cholesterol (4.2 +/- 1.0 vs 5.5 +/- 1.3 mmol/1), HDL cholesterol (0.9 +/- 0.4 vs 1.2 +/- 0.3 mmol/l), apolipoprotein A1 (0.80 +/- 0.25 vs 1.15 +/- 0.28 g/l) and apolipoprotein B (0.77 +/- 0.28 vs 0.95 +/- 0.28 g/l) showed significantly lower values during the acute infectious process. These analyte concentrations became stable after 15 days with the exception of HDL cholesterol which continued to increase until 6 months (1.2 +/- 0.3 vs 1.3 +/- 0.3 mmol/l, p < 0.01). Patients with non-viral atypical pneumonia showed, on admission, higher triacylglycerol values (1.8 +/- 0.8 vs 1.3 +/- 0.9 mmol/l, p < 0.01) and lower HDL cholesterol values (0.6 +/- 0.3 vs 1.0 +/- 0.4 mmol/l, p < 0.03). Values of aspartate aminotransferase (112 +/- 117 vs 23 +/- 11 U/l, p < 0.001), alanine aminotransferase (127 +/- 141 vs 24 +/- 16 U/l, p < 0.02) and gamma-glutamyl transferase (113 +/- 158 vs 33 +/- 25 U/l, p < 0.03) were higher in the subgroup of non-viral atypical pneumonia. In conclusion, patients with community-acquired pneumonia present a significant decline in total cholesterol, HDL cholesterol and apolipoprotein A1 and B concentrations. Lower concentrations of HDL cholesterol are maintained up 15 days. Patients with non-viral atypical pneumonia present on admission significantly higher triacylglycerol and lower HDL cholesterol values. Those with non-viral atypical pneumonia also present higher transaminase values.

Adolescent↗
PubMed1995

Prevalence and upper limit of cardiac hypertrophy in professional cyclists.

The term athlete's heart refers to an increased left ventricular mass. Few studies have assessed the prevalence and normal upper limit of cardiac hypertrophy in highly trained cyclists and this was the aim of this study. A group of 40 professional road cyclists [mean age 26 (SD 3) years] who had participated in European competitions for 3-10 years, were evaluated at the beginning of the 1992-93 season. Evaluation included a clinical history and physical examination, one and two-dimensional echocardiography, 12-lead resting electrocardiogram and a graded exercise test. Determination of the left ventricular mass index (LVMI) was performed using Devereux's formula with correction for the body surface area. Systolic and diastolic blood pressure were measured at rest and at peak exercise. Of the group 23 cyclists (58%) presented a LVMI greater than 130 g.m-2, 21 cyclists presented a diastolic ventricular thickness equal to or greater than 13 mm, with a superior limit of 19 mm; 3 cyclists presented asymmetrical septum hypertrophy; and the relationship between posterior wall and left ventricular diastolic radius was equal to or greater than 0.45 in 14 cases (35%). Electrocardiographic abnormalities of ST-T segment were seen in only 1 subject. No correlation was found between the degree of ventricular hypertrophy and arterial blood pressure. We concluded that these professional cyclists showed a high prevalence of cardiac hypertrophy (58%). The distribution of this hypertrophy was concentric in 20/33 and asymmetric in 3/23 of the subjects with left ventricular hypertrophy. The electrocardiograms were normal in 98% of the subjects.

Adult↗
PubMed1995

Aldosterone levels and cardiac hypertrophy in professional cyclists.

Aldosterone has been associated with the development of cardiac hypertrophy and a correlation has been found between levels of aldosterone and the degree of cardiac hypertrophy in hypertensive patients. Our study aimed to test the relation between physiologic cardiac hypertrophy and serum aldosterone in a group of highly trained cyclists. Determination of the left ventricular mass index (LVMI) was performed in a group of 40 professional cyclists by using Devereux's formula with correction for body surface area. After an overnight fast, blood samples were collected and serum aldosterone levels were measured using RIA. LVMI and serum aldosterone were intercorrelated using linear regression analysis. Twenty-three of the 40 cyclists (58%) presented an LVMI > 130 g.m-1 and the other 17 subjects (42%) presented an LVMI < 130 g.m-1. Serum aldosterone levels did not correlate with LVMI in either of the groups (LVMI > 130 g.m-1, r = -0.089; LVMI < 130 g.m-1, r = 0.146). The lack of correlation of this hypertrophy with serum aldosterone levels suggests that physiologic hypertrophy of the athlete's heart could be caused by a different stimulus to that seen in pathologic hypertrophy of hypertensives.

Adult↗
PubMed1995

Interrelationships between lipoprotein(a) and other cardiovascular risk factors.

Lipoprotein(a) [Lp(a)] had been shown to be a strong independent risk factor for ischaemic heart disease. Our aim was to investigate the relationships between Lp(a) and other cardiovascular risk factors. 423 male miners (age 40 +/- 8 years) were analysed according to the following variables: age, arterial blood pressure, alcohol and cigarette consumption, total cholesterol and Lp(a). Analysis of the data was performed using the Kruskal-Wallis and Spearman tests. Analysis of variance showed statistical differences in Lp(a) levels with cigarette consumption (p < 0.02) and age (p < 0.001). No differences with corrected total cholesterol, blood pressure and alcohol consumption were found. Lp(a) and total cholesterol were correlated (p < 0.0001), but after correction for the estimated contribution of Lp(a) cholesterol this significant correlation disappeared. We conclude that male smokers have significantly lower Lp(a) values than non-smokers and those who quit. Our findings suggest that cigarette consumption is a probable environmental factor that might influence Lp(a) levels.

Adult↗
PubMed1993

Restrictive cardiomyopathy caused by chloroquine.

A 59 year old white woman who had been treated with chloroquine phosphate for 25 years presented with signs of congestive heart failure and was diagnosed as having restrictive cardiomyopathy by non-invasive methods. Electron microscopy of a biopsy specimen of skeletal muscle showed lesions compatible with chloroquine myopathy. The patient died five weeks after presentation. Electron microscopy of heart tissue showed similar lesions to those of the skeletal muscle.

Cardiomyopathy, Restrictive↗
PubMed1993

Electrocardiographic patterns in V4R lead in experimental right ventricular infarction of rats.

Twenty-four male rats that became hypertensive after complete ligature of the abdominal aorta, just above the origin of the left renal artery, showed combined myocardial infarction. To study the electrocardiographic patterns of the experimental right ventricular infarction, the V4R right thoracic lead was recorded at different time intervals after aortic ligature. The patterns recorded were as follows: Q waves in 23 cases (95.8%), ST-T segment elevation in 11 cases (45.8%), ST-T segment depression in two cases (8.3%), and decrease in voltage of R wave in four cases (16.6%), with a predominance of the alterations of the ST-T segment in the acute phase and the appearance of Q waves during the subacute phase.

Animals↗
PubMed1992

[A free-ball thrombus in the left atrium in the absence of mitral pathology].

One male 53-year-old that was diagnosed of dilated myocardiopathy two years ago, was admitted at the emergency room by acute pulmonary oedema, showing the two dimensional echocardiographic study one free-floating thrombus in the left atrium. Waiting for surgery the patient suffered a syncope that was diagnosed of embolic origin and the left atrial thrombus has disappeared.

Cardiomyopathy, Dilated↗