Biomedical subjects

G Inchauspe

Publications and source records attributed to G Inchauspe.

20 records · Page 2Linked to original sources

PubMed1987

Mechanism of selectivity in ion-pair high-performance liquid chromatography of aminoglycoside antibiotics using perfluorinated pairing ions.

The behaviour of perfluorinated carboxylic acids as pairing ions for the chromatography of the aminoglycoside antibiotics was studied. As with perhydrogenated pairing ions, the capacity factor can be modified according to the percentage of organic modifier and the nature and concentration of perfluorinated pairing ion in the mobile phase. The special selectivity effect observed with trifluoroacetic acid was investigated and interpreted as a concerted mechanism involving ionic and hydrophobic interactions.

Aminoglycosides↗

PubMed1985

Use of perfluorinated counter ions for the combination of ion pair HPLC and field desorption mass spectrometry. Application to the early characterization of aminoglycoside antibiotics.

The use of perfluorinated carboxylic acids counter ions is described for easy combination of ion pair HPLC and FD-MS. This technique is applied to the analysis of aminoglycoside antibiotics and to the problem of their early characterization from culture broths. Reliable molecular weight informations can be obtained with this method from minute amounts of purified products (10 micrograms) allowing formal identification in most cases.

Aminoglycosides↗