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Biomedical subjects

G Ippoliti

Publications and source records attributed to G Ippoliti.

14 recordsLinked to original sources
PubMed1979

Partial trisomy 1 due to 1/17 translocation in Ph'-positive chronic myelocytic leukemia.

A patient with chronic myelocytic leukaemia (CML) had the Philadelphia chromosome from the standard 9/22 translocation, a partial trisomy 1 secondary to an unbalanced 1/17 translocation, and a more recent clone with the addition of trisomy 22. This is the third case of partial trisomy 1 associated with the Philadelphia chromosome. Trisomy 1 in haematological disorders is discussed with reference to its clinical significance in CML, the segment of chromosome no. 1 involved, and the mechanism of origin of the partial trisomies. Anomalies of chromosome 1, although not specific to any of them, seem to be important in the development of myeloproliferative disorders and of neoplasms in general.

Chromosomes, Human, 1-3↗
PubMed1978

The amyloidosis.

The clinical and pathological features of amyloidosis are examined in the light of a classification based on anatomical models of amyloid distribution: 1) generalised amyloidosis, including primary and secondary sporadic forms, hereditary and familial amyloidosis, and senile amyloidosis; 2) local amyloidosis, including amyloid tumours, neoplasia with amyloid stroma, and other forms. The nature of amyloid is described. Morphological, ultrastructural, biochemical and immunochemical research has shown that: 1) amyloid is a fibrillar protein with a typical EM and X-ray diffraction appearance; 2) two main types of amyloid proteins exist, one related to Ig light chains and found in primary forms and in association with myeloma, the other (called AA proteins) being the main component of secondary forms and certain types of familial amyloidosis; 3) serum proteins structurally related to the AA proteins may be used as amyloid precursors. The cause and mechanisms of amyloid production are becoming clearer. In particular, a relation with the production of Igs has been established. Improved methods for the diagnosis and treatment of the disease will throw more light and the nature of amyloid and its protein precursors.

Age Factors↗
PubMed1977

[2 cases of thorotrastosis].

Two cases of thorotrastosis unsuspected by the patients themselves are reported. Attention is drawn to the relevance of this disease at the present time. Reference is made to the relevant literature in asserting that the pathology of thorotrastosis must be understood if early diagnosis is to be obtained, and so initiate suitable treatment and satisfy medicolegal requirements.

Aged↗