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Biomedical subjects

G J Acton

Publications and source records attributed to G J Acton.

At least 19 recordsLinked to original sources
PubMed2001

Interventions to reduce the burden of caregiving for an adult with dementia: a meta-analysis.

Because of conflicting results, in order to clarify the state of the science it was necessary to do a systematic analysis of the literature on research testing the effect of interventions on the burden of persons caring for family members with dementia. The purpose of this study was to evaluate, using meta-analytic techniques, those intervention strategies (support group, education, psychoeducation, counseling, respite care, and multicomponent) designed to help caregivers cope with the burden of caregiving. Using meta-analytic methods developed by Glass, McGraw, and Smith (1981) and Hedges and Olkin (1985), 24 published research reports testing 27 treatments for caregivers of adults with dementia were synthesized. Overall, the analysis showed that collectively the interventions had no effect on caregiver burden. Only the category of multicomponent interventions significantly reduced caregiver burden. Burden may be too global an outcome to be affected consistently by intervention. Better and more precise measures are needed to evaluate the effects of caregiver interventions properly.

Caregivers↗
PubMed2001

Meta-analysis: a tool for evidence-based practice.

Evidence-based practice rests on the knowledge generated from sound empirical research combined with clinical expertise. However, many clinicians lack the time to evaluate multiple studies. Meta-analysis is a statistical procedure for combining the results of multiple studies investigating a common problem or issue to produce a pooled effect size, and to evaluate the efficacy of interventions across studies. Meta-analysis can thus be used to synthesize and integrate empirical research to provide important evidence for best-practice decisions. This article examines the meta-analysis process and its links to evidence-based practice.

Evidence-Based Medicine↗
PubMed2000

Basic need status and health-promoting self-care behavior in adults.

Health-promoting self-care behavior emphasizing positive lifestyle practices may improve the health and quality of life of adults. One variable that may influence health-related decisions is the status of basic needs as described by Maslow. The purpose of this study was to investigate the relationships among basic need satisfaction, health-promoting self-care behavior, and selected demographic variables in a sample of community-dwelling adults. A convenience sample of 84 community-dwelling adults was recruited to complete the Basic Need Satisfaction Inventory, the Health-Promoting Lifestyle Profile II, and demographic information. Results of the study indicated that self-actualization, physical, and love/belonging need satisfaction accounted for 64% of the variance in health-promoting self-care behavior. The findings of this study are consistent with Maslow's theory of human motivation and suggest that persons who are more fulfilled and content with themselves and their lives, have physical need satisfaction, and have positive connections with others may be able to make better decisions regarding positive health-promoting self-care behaviors.

Adult↗
PubMed2000

Self-transcendence and family caregivers of adults with dementia.

Research has documented that caring for a family member with dementia is stressful and burdensome. However, difficult life experiences such as fear, loss, and grief may help persons move beyond a concern for self toward a larger perspective and concern for others. Both positive and negative experiences can promote positive movement toward growth and development. This movement has been described as self-transcendence, or the ability to look beyond the self and present difficulties, to extend concern to others, and to find personal meaning and wholeness in the context of life-changing events. The family caregiving experience with its inherent difficulties might provide the impetus for such a movement toward self-transcendence. The purpose of this article is to examine the concept of self-transcendence, explore its linkages to the caregiving experience, and suggest potential strategies to assist family caregivers to achieve self-transcendence.

Adaptation, Psychological↗
PubMed1999

Communicating with individuals with dementia. The impaired person's perspective.

1 To better meet needs of individuals with dementia, caregivers should focus on receiving and interpreting verbal and nonverbal messages conveyed by the afflicted individuals. 2 Prior research has focused on enhancing communication from caregivers to individuals with dementia; however, the content and meaning of communication received from individuals with dementia remains largely unexplored. 3 This study demonstrates that individuals with dementia are able to transmit meaningful communication and this communication can be interpreted by others, making client-centered interventions possible with this population. 4 If care models based on communication interpretation techniques can be built, perhaps the needs of individuals with dementia can be better met, tensions reduced, problematic behaviors decreased, and quality of life enhanced.

Aged↗
PubMed1997

Theory-based nursing practice.

Theory provides nurses with a perspective with which to view client situations, a way to organize the hundreds of data bits encountered in the day-to-day care of clients, and a way to analyse and interpret the information. A theoretical perspective allows the nurse to plan and implement care purposefully and proactively. When nurses practice purposefully and systematically, they are more efficient, have better control over the outcomes of their care, and are better able to communicate with others. Health care agencies can designate a specific nursing theory to guide the nursing practice within the entire organization. The critical component in choosing a nursing theory for an organization is the 'fit' between the philosophical assumptions of the organization and the theory. Modelling and role-modelling, a theory and paradigm for nursing, can be implemented in any setting. Hospice is a concept of care, not a place. Hospice care illustrates the excellent 'fit' between an existing philosophy of care and theory-based nursing practice. The 'fit' is based on the similarity of the philosophical assumptions of hospice and the nursing theory of modelling and role-modelling.

Aged↗
PubMed1997

Stress, hope, and well-being of women caring for family members with Alzheimer's disease.

The article describes a study that tested a midrange model of caregiver stress mediation in women caring for a family member with Alzheimer's disease. The study was grounded in the nursing theory of modeling and role modeling and tested two hypotheses based on theoretically derived propositions. A convenience sample of 88 female caregivers participating in a larger study completed measures of perceived stress, hope, and well-being. Significant correlations among the three variables occurred in the expected directions. Hope was found to mediate the relationship between stress and well-being, providing tentative support for the theoretically proposed linkages.

Adult↗
PubMed1997

Explicating middle-range theory through methodological diversity.

Debates about methodological diversity and the most appropriate paradigm for scientific inquiry are still flourishing within the community of nurse scholars. Rather than continuing to debate these controversies, the authors of this article suggest that nurse researchers set aside methodological differences and move to discover the truths that will build the foundational base of nursing practice and, thus advance the discipline. This article discusses the multiple methodological perspectives used to explicate middle-range concepts from the theory and paradigm for nursing, Modeling and Role-Modeling. Each author will demonstrate how combining different approaches and methodologies can be helpful in exploring and validating middle-range concepts.

Adaptation, Psychological↗
PubMed1997

Affiliated-individuation as a mediator of stress and burden in caregivers of adults with dementia.

The purpose of this study was to test a midrange model based on Modeling and Role-Modeling Theory. The self-care resource of affiliated-individuation was tested to determine its mediational qualities between the stress and burden of caregiving and caregiver life satisfaction. The sample of 107 family caregivers of adults with dementia completed measures of stress, burden, affiliation, individuation, and life satisfaction. All variables were correlated in the expected direction. Affiliated-individuation decreased the effects of stress and burden on caregiver life satisfaction, lending support for the theory-based model.

Adult↗
PubMed1991

Theory-testing research: building the science.

Lack of emphasis on the empirical validation of nursing models has hindered the development of nursing science. This article explores issues concerning theory development in nursing and criteria for evaluating theory-testing research. From a comprehensive review of the literature on theory testing, 15 criteria are identified as essential for evaluating theory-testing studies. The criteria are applied to selected research reports, and recommendations for future use of criteria are suggested.

Humans↗
PubMed1979

A releationship between protein-degradation rates in vivo, isoelectric points, and molecular weights obtained by using density labelling.

1. Half-lives of five plant enzymes were estimated by rate-labeling with 2H2O on the assumption that loss of catalytic activity is equivalent to protein degradation. 2. This involved measuring band-broadening of activity profiles after isopycnic centrifugation. 3. Isoelectric points were determined by isoelectric focusing, and molecular weights were estimated by gel filtration. 4. The conclusion is drawn from the experimental evidence presented that a weak correlation exists between rates of degradation and isoelectric points (r = 0.699; P greater than 0.10; not significant). 5. A highly significant relationship exists between the logarithm of subunit size and half-life (r = -0.939; P greater than 0.02). 6. A literature survey confirmed the trends observed.

Centrifugation, Isopycnic↗
PubMed1979

Purification to homogeneity and some properties of L-phenylalanine ammonia-lyase of irradiated mustard (Sinapis alba L.) cotyledons.

1. Lyase (L-Phenylalanine ammonia-lyase, EC 4.3.1.5) from far-red light-irradiated mustard cotyledons was purified to a single protein using ammonium sulphate fractionation, column chromatography on L-phenylalanyl-Sepharose 4B and on Sephadex G-200, isoelectric focusing and polyacryalmide gel electrophoresis. 2. The enzyme constituted 0.01% of total cellular protein, did not catalyse the deamination of L-tyrosine, had a pH optimum of pH 8.6 and an isoelectric point of pH 5.6. 3. The sedimentation coefficient was estimated as 11.3 S, the Stokes' radius 4.25 nm, and the molecular weight 240 000 +/- 9000 (S.E.). 4. Electrophoresis on denaturing polyacrylamide gels gave a single stained protein band corresponding to a subunit molecular weight of 55 000 indicating a tetrameric structure of equal (or near-equal) size subunits. 5. Maximum velocity (V) for the purified lyase at 25 degrees C was 3.83--4.10 nkat. 1(-1) enzyme and Km value 0.151--0.154 mM. Negative cooperativity (Hill coefficient, n = 1.08) was not detected over the substrate concentration range tested. 6. A putative non-diffusible inhibitor isolated from dark-grown gherkin hypocotyls inhibited the homogeneously purified mustard lyase.

Ammonia-Lyases↗
PubMed1975

Control over activation or synthesis of phenylalanine ammonia-lyase by phytochrome in mustard (Sinapis alba L.)? A contribution to eliminate some misconceptions.

1. Density labelling with 80 atom% of 2H2O has been used to examine the mode of action of phytochrome (continuous far-red light) in increasing levels of L-phenylalanine ammonia-lyase (EC 4.3.1.5) activity in cotyledons of developing mustard seedlings (Sinapis alba L.). 2. Bandwidths and density shifts of isopycnically banded enzyme show that in darkness the enzyme was synthesized de novo, continuously turning over (half-life approx. 3 h) and that maximum labelling achievable was reached at 12 h. 3. 2-fold (6h), 5-fold (12h) and 10-fold (24 h) light-mediated increases in enzyme activity were accompanied by a similar pattern of labelling as observed in darkness. 4. Experimental evidence and theoretical arguments are presented which make it unlikely that phytochrome increases enzyme activity by slowing down the rate of degradation or by activating preformed enzyme molecules. 5. The conclusion is drawn that the rate of turnover of phenylalanine ammonia-lyase in dark-grown mustard cotyledons is too rapid compared to the measured rise in enzyme activity for density labelling to reveal directly control over the rate of synthesis de novo by phytochrome. However, the elimination of other control mechanisms leads us to the conclusion that phytochrome most probably does control synthesis of this enzyme in mustard, which agrees with the previous findings for parsley cells.

Ammonia-Lyases↗
PubMed1974

Phytochrome-induced synthesis of ribonuclease de novo in lupin hypocotyl sections.

1. Density-labelling with 99 atoms% of (2)H(2)O distinguished pre-existing from newly synthesized ribonuclease molecules in sections of developing hypocotyl tissue. 2. Activity profiles of enzyme extracted from the fraction pelletable at 100000g showed heterogeneity after isopycnic centrifugation in CsCl gradients. 3. Measurement of density shifts of the entire heterogeneous band shows that ribonuclease protein is synthesized de novo in both continuous far-red light and darkness. 4. A twofold increase in enzyme activity after irradiation was accompanied by band-broadening and a significantly faster rate of labelling than in darkness. 5. The conclusion is drawn from the experimental evidence and theoretical arguments presented that phytochrome regulates the synthesis of new enzyme molecules against a background of continuous (dark-rate) synthesis and degradation. 6. Further information has been deposited as Supplementary Publication SUP 50033 (3 pages) at the British Library Lending Division (formerly the National Lending Library for Science and Technology), Boston Spa, Yorks. LS23 7BQ, U.K., from whom copies can be obtained on the terms indicated in Biochem. J. (1973), 131, 5.

Alkaline Phosphatase↗
PubMedDate not supplied

Communication from individuals with advanced DAT: can it provide clues to their sense of self-awareness and well-being?

Often communication from people with advanced dementia of the Alzheimer type (DAT) is regarded as incoherent and meaningless. However, with careful listening and observation, such communication often becomes more understandable. To better understand DAT communication, the investigators designed an exploratory qualitative study to videotape and critically analyze conversations between a clinical nurse specialist and 15 subjects with DAT ranging from mild to severe. One of the findings was that, even in later stages, indications were given that subjects had self-awareness of their cognitive decline. The investigators further examined the communication of the five most cognitively impaired subjects for other indications of self-awareness and well-being. To demonstrate this premise of awareness of cognitive decline and self in the later stages of DAT, excerpts from communication received from five subjects with advanced cognitive impairment are presented.

Aged↗
PubMedDate not supplied

The relationship between basic need satisfaction and emotional eating.

Eating in response to emotions may lead to the consumption of excessive calories which typically leads to weight gain. This study examined the relationship between basic need satisfaction as identified by Maslow's hierarchy and emotional eating. According to Modeling and Role-Modeling theory, when lack of basic need satisfaction functions as a stressor, individuals may be more likely to engage in emotional eating as a substitute for fulfilling their needs in order to maintain homeostasis. The Basic Need Satisfaction Inventory (BNSI) had a strong, negative correlation (r = -.49; p < .001) to the Emotional Eating Scale (EES) indicating that the lower the level of basic need satisfaction, the more likely one engaged in emotional eating. In predicting EES score, 27.7% of the variance was explained by the self-esteem subscale of BNSI. This study supports looking at underlying issues contributing to weight gain in order to develop effective interventions for weight management.

Adaptation, Psychological↗