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Biomedical subjects

G J Bonde

Publications and source records attributed to G J Bonde.

13 recordsLinked to original sources
PubMed1982

Serum antibodies and immunoglobulins in smokers and nonsmokers.

Antibodies to antigens in humidifier water were detected by double immunodiffusion in 30 of 63 (47.6%) persons who were exposed to aerosols from a water humidification unit in a cigar plant, whereas no antibodies could be detected in 49 unexposed blood donors (P less than 0.001). The presence of antibodies could not be related to fever or pulmonary symptoms (cough, expectoration, dyspnoe). Antibodies were found in 14 (93.3%) of 15 nonsmokers and in only 13 (31.7%) of 41 smokers (P less than 0.001), and the titres were highest in nonsmokers. Serum IgG and IgA levels were higher in nonsmokers than in smokers, and the variances within the groups were significantly different (F less than 0.05 and F less than 0.05, respectively). The mean serum IgM values were not significantly different in the two groups. Antibodies to Candida albicans and Escherichia coli 04 and 075 were detected with equal prevalences and titres in smokers and nonsmokers. These findings suggest that tobacco smoking may suppress the humoral immune response to inhaled antigens but not to antigens which are supposed to be absorbed through membranes other than those of the bronchopulmonary system. They may partly explain the reported increased incidence of allergic alveolitis in nonsmokers.

Adolescent↗
PubMed1981

Salmonella and other pathogenic bacteria.

The bacterial origin of waterborne diseases was discovered at the turn of this century. Introduction of slow sandfiltration, chlorination, and bacteriological control dates back to the same period. Although greater concern is given to-day to chemical pollutants or to viruses, bacteria are still a menace to countries with advanced water treatment. Within the last decade outbreaks were reported in Europe and the US due to Salmonella types, Shigella, E. coli, and to Vibrio cholerae, generally due to deficiencies in treatment, and often caused by smaller private works. A wider spectrum of bacteria must be taken into consideration to-day, Enterobacteriaceae are still the most important including Yersinia, E. coli, Klebsiella, and Enterobacter. The opportunistic microorganisms (pseudomonads, Acinetobacter, Campylobacter, Aeromonas, Flavobacterium) can also be a danger.

Bacterial Infections↗
PubMed1966

[Gas gangrene].

Explore the source record for details and available documents.

Clostridium perfringens↗
PubMedDate not supplied

Respiratory disease and lung function in a tobacco industry.

In a field study, 75 workers from a cheroot factory were compared with 50 reference workers from a large telephone company. Questionnaire responses revealed higher prevalences of cough and shortness of breath on exercise among the tobacco workers than controls. Cigarette smoking was the same in the two groups, but tobacco workers also smoked cheroots. Significantly decreased values (p less than .01) of forced expiratory volume in 1 sec (FEV1.0) and forced vital capacity (FVC) were found among tobacco workers compared to referents. After adjusting for number of cigarettes and cheroots smoked, there remained no significant differences. There was a suggestion (p less than .10) of decreased FEV1.0 among light or nonsmoking tobacco workers. When cigarette consumption only was considered, this difference was significant (p less than .01). Lung function values were not associated with the very low measured dust exposures. Bronchial reactivity to inhaled histamine, diurnal and weekly changes in FEV1.0, skin-prick tests with tobacco extracts, and precipitating serum antibodies to tobacco extracts and extracts of microorganisms were similar to that expected in a nonexposed population. Differences in lung function between the two groups may result from excess cheroot consumption and higher previous exposure to tobacco dust among the tobacco workers.

Adult↗