PubMed Health⌕ Search

Biomedical subjects

G J Brooks

Publications and source records attributed to G J Brooks.

7 recordsLinked to original sources
PubMed1996

The effects of time interval after venipuncture and of anticoagulation on platelet adhesion and aggregation.

Abnormal platelet function plays an important role in atherosclerosis and thrombotic disorders. Simple in vitro testing of platelet function is preferable to other techniques, and adhesion measurement is especially important because it reflects an immediate platelet response. The time lapse after venipuncture and the anticoagulant may affect platelet function in an as yet unknown way. A method for determining platelet adhesion under controlled whole blood flow conditions and an aggregation study were used. Platelet adhesion and aggregation changed significantly with time elapsed since venipuncture, peaking after 60 min (P < 0.05): a plateau was reached only after more than 120 min. Platelet adhesion was directly suppressed by the use of sodium citrate as an anticoagulant, and surface density decreased from 14.2 to 8.8 (P < 0.001). To prevent the effect of time after venipuncture on platelet function, testing should be performed at the plateau phase.

Adenosine Diphosphate↗
PubMed1993

Information overload.

Explore the source record for details and available documents.

Information Storage and Retrieval↗
PubMed1992

DERMIS: a computer system for assisting primary-care physicians with dermatological diagnosis.

DERMIS is a computerized skin disease diagnostic prompting system which has been derived from the prospective study of 5203 cases. It has been designed for use by non-dermatologists such as general practitioners. The program produces a list of reasonable diagnoses based on probabilities calculated using Bayes' theorem. Out of 221 precise diagnoses made by the dermatologist in the clinic, 42 groupings were created to encompass the most common or important diseases encountered in general practice. Four 'remainder' or 'send to specialist' groups were included for the 13% of uncommon conditions. The program, when tested by 'one out' analysis on the original cases, placed the correct diagnosis first on 76% of occasions, and within the first three on 95% of occasions. In 76 of 125 cases randomly selected from the data base, a request for diagnostic assistance had been made by the referring general practitioner. It has been estimated that in 54 of these 76 cases the DERMIS system could have provided differential advice with the correct diagnosis appearing at the top of the list. The system has been written in MUMPS and runs on an IBM-compatible desk-top computer. The software allows real time data entry. Arrangements are in hand for performing clinical trials of the system in general practice. If current performance is maintained, and the response to the system's output is favourable, then DERMIS might well enhance performance in medical decision making for the benefit of patients, medical services and budget holders.

Diagnosis, Computer-Assisted↗
PubMed1986

Pulmonary barotrauma in submarine escape trainees and the treatment of cerebral arterial air embolism.

The reports of all dysbaric incidents occurring during submarine escape training at the Royal Navy's training facility in HMS Dolphin during 1954-84 were reviewed. All cases treated for unequivocal arterial gas embolism were used to assess the effectiveness of various treatments. Presentation and accident rates were analysed. As training techniques and treatments have varied over the years, the data were not uniform thus making comparison of treatments difficult. Both long air tables and RN Table 63 (USN6A) appear to offer effective treatment. There was insufficient data to assess the efficacy of prophylactic steroids in preventing relapse. It was concluded that the current recommendations for treating AGE by commencing on RN Table 63 with a change to RN Table 54 in the event of no response or of relapse should remain unchanged.

Accident Prevention↗