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Biomedical subjects

G J Jahn

Publications and source records attributed to G J Jahn.

14 recordsLinked to original sources
PubMed1988

[Virologic considerations in donor selection for allogeneic keratoplasty].

Over a period of 14 months (from October 1985 to December 1986) 152 potential cornea donors were evaluated for human immunodeficiency virus (HIV) and hepatitis B surface (HBs) antigen. In three clinically normal donors (two deaths due to natural causes, one as a result of an automobile accident), HIV seroconversion was found by ELISA techniques in two cases and a positive Western Blot test in one. The two elderly patients had previously undergone multiple blood transfusions during major abdominal surgery in smaller community hospitals before blood donors were routinely tested for HIV; one 20-year-old patient was probably a homosexual, as in-depth interviews with his family doctor revealed. Hepatitis B serology was positive in four potential cornea donors. The authors conclude that interdisciplinary work-ups of potential cornea donors should include screening for infectious diseases.

Acquired Immunodeficiency Syndrome↗
PubMed1987

Evaluation of diagnostic tools for adult chlamydial keratoconjunctivitis.

Conjunctival smears and serum specimens of 150 patients with presumed chlamydial keratoconjunctivitis were evaluated over a period of 16 months and compared to age- and sex-matched healthy controls. Sensitivity, specificity, and predictive values of fluorescent monoclonal antibody (FMAb) direct tests, IgG single antigen tests for the detection of serum antibody (IgG-IFT), and IgA and IgG immunoperoxidase tests (IgA-IPAs and IgG-IPAs) for serum antibody were compared to McCoy cell culture techniques in a nonoptimized clinical setting. Thus, FMAb sensitivity was 100%, specificity was 52%, and predictive value was 30%. IgG-IFT sensitivity was 94%, specificity was 67%, and predictive value was 37%. IgA-IPA sensitivity was 100%, specificity was 70%, and predictive value was 40%. The IgG-IPA was sensitive but nonspecific. With respect to the current epidemiologic situation in our area, FMAb and IgA-IPA in addition to McCoy cell culture techniques may represent valuable diagnostic tools for the detection of chlamydial disease.

Adult↗
PubMed1987

[Several years' course of an oculogenital Chlamydia infection].

A 46-year-old woman had been suffering from recurrent bilateral keratoconjunctivitis, vascularized corneal scars, and incipient pannus vasculosus for five years. Oculogenital chlamydial disease was diagnosed by Giemsa stains, McCoy cell culture, and serum IgG immunofluorescent techniques. Isolates from cervical smears were positive for C. trachomatis in cell cultures. Systemic therapy with doxycycline 200 mg per day for 14 days resulted in resolution of the acute symptoms and no further recurrences. The patient's partner was also treated with tetracyclines. Because of reduction of vision, a lamellar corneal grafting was performed.

Chlamydia Infections↗
PubMed1987

[Diagnosis of ocular Chlamydia infections by direct detection].

Conjunctival smears of 75 patients with a presumptive diagnosis of oculogenital chlamydial infection were evaluated with the monoclonal antibody direct test (SyvaMerck and Orion Research). 69 isolates were correlated with McCoy cell cultures and serum IgG immunofluorescent tests. Sensitivity (100%) and specificity (56-76%) of the monoclonal antibody direct test was comparable to data from recently published studies on genital smears.

Antibodies, Monoclonal↗
PubMed1987

[The cat as a possible infection source for Chlamydia psittaci keratoconjunctivitis in humans].

Acute follicular keratoconjunctivitis in a 25-year-old female patient was diagnosed as an infection with Chlamydia psittaci supposedly originating from a household cat with similar symptoms. The diagnosis was based on clinical symptoms, the appearance of Chlamydia-psittaci-specific IgM in the patient and the cat, and excluded other pathogenic agents. Chlamydiae organisms could not be isolated, probably due to prior antibiotic treatment. Two weeks of continuous treatment led to complete recovery of the patient and the cat. Other zoonotic infections of conjunctivitis in cats and keratoconjunctivitis in man caused by Chlamydia psittaci are mentioned.

Adult↗
PubMed1986

Epidemiology of chlamydial eye diseases in a mixed rural/urban population of West Germany.

4260 conjunctival specimens of 2850 outpatients with keratoconjunctivitis of presumed infectious etiology were studied. Two thousand six hundred sixty-eight specimens (63%) revealed growth of bacteria, and 80 (2%) growth of fungi. One hundred ninety-nine specimens (5%) were McCoy cell culture or direct stain (monoclonal antibody or Giemsa) positive for Chlamydia trachomatis. two patients had a C. psittaci infection (ELISA techniques). In patients with keratoconjunctivitis of bacterial etiology, overall incidence of McCoy cell culture-proven chlamydial infections was 7%; in the 20 to 30-year age group it was 12.5%. Simultaneous infections of chlamydiae and other bacteria were seen in 34 patients. Since sensitive and specific tests to diagnose chlamydial infections are available, ophthalmologists may be able to prevent these infections by agent-specific antibiotic therapy.

Adult↗
PubMed1986

[Keratoconjunctivitis caused by Chlamydia psittaci].

A 25-year-old female patient suffering from acute follicular keratoconjunctivitis with epithelial and subepithelial corneal infiltrates was examined. Antibodies of the IgM class directed against C. psittaci were found. Infection due to C. trachomatis was ruled out by serology (ELISA) and negative isolation attempts. The patient's cat had rhinitis and conjunctivitis and a positive C. psittaci specific IgM antibody titer. Systemic application of tetracycline resulted in fast resolution of symptoms in both the patient and her cat.

Adult↗
PubMed1985

[Corneal symptoms in keratoconjunctivitis caused by Chlamydia].

Between December 1983 and June 1984 280 patients with keratoconjunctivitis had a laboratory work-up for Chlamydia trachomatis infections. Serologic or culture tests produced positive results in 114 cases. Of these, 3 were neonatal blennorrheas and 111 chlamydial keratoconjunctivitides in adults. Corneal involvement was seen in 57 patients. Diffuse punctate keratopathy was noted frequently. Stromal infiltrates were sometimes found in the limbal area distributed evenly over the cornea. Corneal scars were diagnosed in 11 patients and pannus vasculosus in 2. The clinical range of corneal symptoms in chlamydial infections is illustrated with reference to 4 patients.

Adult↗
PubMed1984

[Evaluation of infectious, inflammatory external eye diseases].

Over a period of 4 months the authors observed 240 outpatients with 302 "red eyes." Oculogenital strains of Chlamydia trachomatis were diagnosed in 12.5% of these cases. Bacterial monoinfections were found in 13.9%, coinfections in 63.9%. The remaining 9.7% included Candida sp. (4%) and Herpes I (1.4%) infections, while 4.3% remained unidentified. Allergic conjunctivitis and "dry eye" syndromes were not considered separately in this study. Specific antibiotic therapy improved the clinical condition due to "saprophytic" bacterial coinfections, indicating the pathogenic importance of this type of infection.

Adolescent↗
PubMed1983

[Massive blenorrhea in a newborn infant caused by a Chlamydia trachomatis subtype].

An 8-day-old baby girl was found to be suffering from massive blennorrhoea caused by a strain of Chlamydia trachomatis. Differential diagnosis included possible bacterial (e.g. Pseudomonas, Staphylococci and Haemophilus sp.) and viral causes of the disease. A 10-day systemic therapy with erythromycin 50 mg/kg/body weight is sufficient to prevent possible complications such as pneumonia. The parents also have to be treated for this disease.

Chlamydia trachomatis↗