Lack of ragweed in northwestern US.
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Allergens↗
Biomedical subjects
G J Kadlec
Publications and source records attributed to G J Kadlec.
Pharmacokinetics and taste acceptance of an alcohol-free oxtriphylline solution.
As follow-up to earlier studies done on the pharmacokinetics of theophylline preparations in young children, an alcohol-free oxtriphylline syrup preparation was studied. Oxtriphylline syrup demonstrated no appreciable change in the pharmacokinetic parameter of half-life in this young age group. Therapeutic dose relationship were studied in conjunction with trough level measurements. Patient acceptance of this preparation is judged to be excellent.
Asthma↗
Non-compliance in asthmatic children: a study of theophylline levels in a pediatric emergency room population.
Sub-therapeutic theophylline levels due to patient (parent) non-compliance is a significant cause of outpatient treatment failure in childhood asthma. In a study of 50 known asthmatic children with acute asthmatic episodes, 98% had sub-therapeutic theophylline levels less than 10 mcg/ml with 75.5% due to inadequate patient (parent) compliance.
Adolescent↗
Corticosteroids in asthma.
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Adrenal Cortex Hormones↗
Effect of ampicillin on theophylline half-life in infants and young children.
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Ampicillin↗
Theophylline half-life in infants and young children.
Pharmacokinetics of theophylline elimination were studied in a 54-child population. Subjects' ages ranged from three months to six years. The mean half life was 4.92 hours, with S.D. +/- 1.88 hours. This is at variance with previous reports. Ages and half lives were compared and there were no correlations in this young age group.
Child↗
Acute theophylline intoxication. Biphasic first order elimination kinetics in a child.
An acute theophylline intoxication in a child is reported. It was characterized by two distinct first-order elimination processes with t1/2 = 12.6 hr (ke = 0.056 hr-1) and t1/2 = 5.4 hr (ke = 0.128 hr1), respectively. It is proposed that the slower process, which was seen at high plasma levels, represents renal plus saturated hepatic elimination. The later, more rapid process seen at therapeutic plasma levels is consistent with hepatic elimination by biotransformation.
Acute Disease↗