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Biomedical subjects

G J Matz

Publications and source records attributed to G J Matz.

9 recordsLinked to original sources
PubMed1979

Sequential combination chemotherapy for advanced squamous cell carcinoma of the head and neck.

Thirty-four patients with advanced squamous cell carcinoma of the head and neck have been treated with sequential combination chemotherapy consisting of Cytoxan, methotrexate, oncovin, bleomycin and adriamycin, followed by Leucovorin (COMBAL). All patients had undergone extensive prior radiation and/or surgery. All the patients had recurrent cancer. Toxicity included two deaths from drug induced pancytophenia and one from sepsis. Treatment was well tolerated and could be given in the outpatient clinic. No bleomycin pulmonary or adriamycin cardiac toxicity was seen. Results include 4 patients who achieved complete remission, objective improvement in measurable lesions in 6 others, stabilization of disease for 1 to 3 mo. in 5, and progression of disease in 13. Survival has ranged from 1 to 19+ months with a median of 10.7 mo. for patients that were evaluated. We conclude that COMBAL produces objective evidence of improvement in approximately 45% of patients with far advanced, previously treated squamous cell carcinoma of the head and neck.

Adolescent↗
PubMed1977

Comparative clinical studies of ototoxicity and nephrotoxicity of amikacin and gentamicin.

A comparative study of the oto- and nephrotoxicity of amikacin and gentamicin was carried out prospectively. Twenty-six gentamicin-treated patients and 27 amikacin-treated patients were monitored for changes in auditory and renal function during and after therapy. Thirteen of those treated with gentamicin and 20 of those treated with amikacin underwent vestibular caloric testing which could be evaluated for evidence of toxicity. In four (15.4%) of the gentamicin-treated patients, nephrotoxicity developed; no such toxicity was seen in the amikacin-treated patients. This difference may have been due to a fortuitously higher incidence of pretreatment renal impairment in the gentamicin-treated group. In two gentamicin-treated patients (7.7%), ototoxicity developed (one auditory, one vestibular), and in two amikacin-treated patients (7.4%), auditory toxicity developed. Statistical analysis of oto- and nephrotoxicity and their risk factors was not attempted because of the small numbers of patients who could be evaluated. Additional patients are being studied.

Adult↗
PubMed1976

The ototoxic effects of ethacrynic acid in man and animals.

A review of the literature was carried out to summarize the ototoxic effects of ethacrynic acid on man and animal. The effects of this drug on the electrolytes of the endolymphatic and perilymphatic systems, on the cochlear potentials and the auditory cortical-evoked responses, were reviewed. Histological animal studies determined by light and electron microscopy were described. Potentiation of this drug with previous aminoglycoside therapy was discussed. In this paper, a human case report with temporal bone findings was present in addition to the histopathological effects of this drug which were shown in a series of animals receiving this drug over a period of time. Edematous and cellular changes in the stria vascularis, especially with animals receiving large doses of the drug, were described. No permanent alterations in the cochlear potentials resulted from the long-term therapy with ethacrynic acid.

Animals↗
PubMedDate not supplied

Suggestions for monitoring patients during treatment with aminoglycoside antibiotics.

Guidelines are suggested for the surveillance and prevention of ototoxicity in adults, based on experience and a compilation of opinions from otolaryngologists and infectious disease specialists. The influence of dosage and renal function on serum levels and their relevance to ototoxicity are discussed. Indications for testing of inner ear function are considered.

Amikacin↗
PubMedDate not supplied

Bleomycin.

Explore the source record for details and available documents.

Bleomycin↗
PubMedDate not supplied

Chondrosarcoma of the nasal septum extending into the maxillary sinus.

A case of chondrosarcoma of the nasal septum extending into the maxillary sinus is presented. These cartilaginous tumors are rare in the head and neck, with only 21 reported in the maxilla and four in the nasal septum. Careful histologic analysis is required for correct diagnosis. The present case was treated with an en bloc ethmoidectomy and medial maxillectomy, followed by fast neutron radiation therapy. The therapeutic program is analyzed for opportunity to provide an excellent chance of cure.

Adult↗
PubMedDate not supplied

Laryngeal stenosis in acromegaly: a possible cause of airway difficulties associated with anesthesia.

After difficult intubation in an acromegalic patient was encountered, 7 additional acromegalic patients were studied by measuring the cricoid width and anteroposterior diameter. Cricoid width and anteroposterior diameter were generally found to be narrower than in a group of normal patients. Such narrowing may explain airway problems encountered in acromegalic surgical patients.

Acromegaly↗