Biomedical subjects
Publications and source records attributed to G J Radcliffe.
Metastatic lesions of the parotid gland are well described in the literature. Metastatic spread to the parotid from renal cell carcinoma is rare. We present the only reported case of facial nerve palsy caused by a metastasis to the parotid from a renal cell carcinoma.
Packing of the nasal cavity following intranasal surgery is still widely practised. The removal of this packing is invariably associated with a significant amount of pain. We designed a prospective randomised case-controlled study to look at the efficacy of 4% lignocaine solution as a potential analgesic in the removal of Merocel nasal packs. Each patient had bilateral packs and acted as his or her own control with one pack being rehydrated with lignocaine and the other with saline. We found that there was a reduction in the level of discomfort experienced on the side rehydrated with lignocaine, although this reduction did not reach significance. We emphasize the importance of rehydration of these packs prior to removal.
Explore the source record for details and available documents.
The presenting features and management of three cases of chondroma and one of chondrosarcoma in different head and neck sites are described. The rarity of this tumour is emphasized by a brief review of the literature. The fact that all the above cases presented within two years to one District General Hospital makes this series very unusual indeed.
A method of producing a soft, comfortable, lightweight immediate obturator is described. This can be changed in an out-patient environment.
Explore the source record for details and available documents.
Scotophobin is a peptide previously extracted from brains of rodents shocked in the dark compartment of a white/dark apparatus and identified as the behaviorally active dark avoidance-inducing factor. This study attempted to ascertain whether a stable synthetic analog of scotophobin induced no adrenocortical stress reaction, a generalized, unconditioned stress reaction, or a stress reaction selectively triggered by the dark compartment of the apparatus. Twenty eight mice were injected IP with the synthetic substance and 28 with placebo. A day later half of each group was placed in the dark compartment and the other half in the light compartment. Fifteen min afterward, the animals were bled, and serum samples were obtained. Plasma corticoid levels were determined by radioassay. Only the animals injected with scotophobin analog and exposed to the dark box had elevated levels. The interaction effect between drug treatment and light or dark environment was highly significant.
Explore the source record for details and available documents.