Mentors and manipulation.
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Allergy and Immunology↗
Biomedical subjects
G J V Nossal
Publications and source records attributed to G J V Nossal.
A healthier climate for the funding of vaccine research.
Vaccination is a marvel of scientific endeavor that benefits the masses. Yet the laissez-faire economy may not provide a sufficient push for vaccine research and development. The current climate that drives this globally important venture is examined here.
Antigens↗
One cell, one antibody: prelude and aftermath.
This essay seeks to summarize one scientist's pilgrim's progress through the world of antibody formation, attempting to capture the flavor of problems as encountered within their times. It seeks to portray a world where the direct template hypothesis ruled the day, where the function of lymphocytes was unknown, let alone the difference between T and B cells, and where antibody genes were but a dream. Struggles to establish the credentials of the clonal selection hypothesis are presented in some detail, as are the implications which followed the 'one cell - one antibody' discovery. The other two main preoccupations of the author are presented more briefly, namely the essential features of the germinal center and the cellular basis of immunological tolerance within the B lymphocyte compartment. Naturally, the experiments become more sophisticated as both knowledge and technology mature. A continuing thread within the unfolding story is that one must not shy away from developing new techniques when problems demand them.
Allergy and Immunology↗