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Biomedical subjects

G J Xie

Publications and source records attributed to G J Xie.

6 recordsLinked to original sources
PubMed2001

[Kindling model of SD rats induced by injection of PTX intraperitoneally].

OBJECTIVE: To observe the kindling model of Sprague-Dawley (SD) rats induced by injection of different doses of picrotoxin (PTX) intraperitoneally, and to evaluate the effect of the drug on the model. METHODS: SD rats were devided randomly into four groups: control group, epilepsy Group I (PTX, 1.5 mg.kg-1.d-1), epilepsy Group II (PTX, 2 mg.kg-1.d-1) and the phenobarbital group. The kindling model of rats was induced by daily injection of PTX intraperitoneally. The seizures in the rats were observed, and the results of electroencephalography (EEG) were recorded. RESULTS: On the 20th day after injection of PTX, 71% SD rats were kindled in epilepsy Group I; 4 rats were dead, 2 rats were at stage IV of convulsions, and 2 rats were at stage V of convulsions in epilepsy Group II; 17% rats were kindled in the phenobarbital group. The EEG demonstrated spike discharges in the kindled rats. CONCLUSIONS: In this models, the better dose of PTX is 1.5 mg.kg-1.d-1, and phenobarbital sodium can protect SD rats injected PTX intraperitoneally from seizure.

Animals↗
PubMed2001

[Study on p53 gene expression following transient ischemia in the gerbil].

OBJECTIVE: To study the expression of p53 gene after transient ischemia in the gerbil. METHODS: Northern blot was used to detect the expression of the p53 mRNA in the forebrain during different periods after post-ischemic reperfusion in the gerbil. RESULTS: The expression of p53 mRNA increased in the forebrain during the 6th hour to the 3rd day of reperfusion following 6 min of ischemia (P < 0.05). CONCLUSION: The high level expression of p53 might induce neuronal apoptosis after ischemia.

Animals↗
PubMed2000

[Heat shock protein 70 expression following transient ischemia in the gerbil].

OBJECTIVE: To study the expression of heat shock protein 70(HSP70) following transient ischemia in the gerbil. METHODS: Immunohistochemistry(IHC) was used to determine the expression of the HSP70 protein in the forebrain during different periods after post-ischemic reperfusion in the gerbil, and the neuronal damage was examined with microscope. RESULTS: The HSP70 protein was only expressed at the 1st day of reperfusion(P < 0.01); and most of the neurons showed damage on the 7th day of reperfusion; heat-preconditioning could increase the expression of HSP70 protein(P < 0.01) and decrease the neuronal damage(P < 0.001) after 6 min of ischemia. CONCLUSION: Heat-preconditioning could protect neural cells from damage by increasing the expression of the HSP70 protein.

Animals↗
PubMed1998

Quality of life and personality in adults with epilepsy.

PURPOSE: This study was undertaken to understand the quality of life, personality, and associated factors in patients with epilepsy. METHODS: 117 patients with epilepsy and 84 healthy people were studied and tested using the Social Support Scale, the General Well-being Schedule, the Life-Event Scale, the Behavior Pattern Scale, and the Eysenck Personality Questionnaire (EPQ). RESULTS: There were no significant differences between the patients with epilepsy and the control group in the Social Support Scale results. The General Well-being Schedule scores were lower for the case patients than for the control group (p < 0.01). Scores for patients with frequent seizures (once a month or more) were lower than those without frequent seizures (less than once per month). The case patients had higher negative scores in the family-related problem section of the Life Events Scale, compared with the control group (p < 0.05). The patients with epilepsy were also more likely to lie (p < 0.05); their emotions were more changeable (p < 0.01), and their character more introverted (p < 0.05), although their behavior patterns were similar to the controls. We also studied associated factors related to personality, general well-being, and familial-negative life-events. CONCLUSIONS: These results provide information about patients with epilepsy that may be useful in their psychological treatment.

Adult↗
PubMed1990

[Pathologic observations on the peripheral nerves in simple polymyositis].

In 6 cases of polymyositis was performed muscle and sural nerve biopsy. All the 6 patients presented typical clinical pictures of simple polymyositis. Sural nerves showed demyelination and axonal changes, under light and electron microscopy. It seems that simple polymyositis accompanied by the alterations in peripheral nerves is not very rare. In 3 cases, a few small arteries in the interfascicular areas of the nerves were nearly totally occluded due to the intimal proliferation. Clinical examination revealed no evidence of systemic vasculitis. On the basis of these data, the authors suspect that the above mentioned pathological findings probably are partial presentations among the spectrum of allergic disorder, which presents many clinical types and various combinations.

Adolescent↗