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Biomedical subjects

G Jörgensen

Publications and source records attributed to G Jörgensen.

At least 19 recordsLinked to original sources
PubMed1985

[Human genetic aspects of inborn ear, nose, and throat diseases].

The genetic analysis of malformations enables us to distinguish four groups of different anomalies: 1. Chromosomal disorders (gene and chromosome mutations). 2. Single (monogenic) hereditary anomalies and malformations (gene mutations: point-mutations). 3. Malformations with polygenic multifactorial basis (combination of genetic and exogenous factors). 4. Exogenous non-hereditary malformations. We were able to classify malformations in one of the four groups using the three most important methods of human genetic investigations: (a) chromosomal analysis, (b) family investigations, (c) twin method. These methods can complement each other, but each has its own individual place. This review quotes examples of the four different etiological groups in otology, especially those affecting parts of the ear as well as those affecting whole ear.

Abnormalities, Drug-Induced↗
PubMed1981

[Human genetics and infectious diseases (author's transl)].

Infectious diseases, especially the worldwide epidemic diseases such as plague, smallpox, syphilis, tuberculosis have to a great extent selective effects. This is demonstrated inter alia in the different "selection values" in the ABO blood group system. Under present day civilized living conditions O carriers have a preservation advantage over blood group A. The deletion of the selection factor "infectious disease", which entails a decline of immunity, may nevertheless regain importance if environmental changes occur.

ABO Blood-Group System↗
PubMed1981

[Possibilities and limitations of genetic family counseling (author's transl)].

Genetic family counseling has gained increasing importance in Germany in recent years, although the material and in particular the personnel requirements are lacking to a considerable extent. It requires careful training and a high sense of responsibility. Wrong advice is worse than none. Besides the "classical" genetic family counseling--before founding a family, after the birth of a sick child, disease in the family, childlessness (eg frequent abortions), elderly parents, particularly mothers, before entering marriage with a blood relation--the individual genetic prognosis and prophylaxis (genetic individual prognosis) should be included more extensively in the "genetic prevention"--which is more than "just" a family counseling. This is particularly true of many frequently polygenic multifactorially induced diseases in general and internal medicine.

Chromosome Aberrations↗
PubMed1981

[Genetic and phylogenetic aspects of games and sports (author's transl)].

Games and sports have increasingly become a biologically necessary adaption reaction of man to his ever easier living conditions due to subjugation of the environment. "Physical performance", defined as the capacity of the individual to cope adequately with the physical and psychic demands of the environment and his career has doubtless played a great part in the phylogenetic development of man. Everything connected with it--and that is not only purely motor, but also corresponding esthesiophysiology and intellectual capacities--has contributed to a considerable extent to the selective formation of man.

Adaptation, Biological↗
PubMed1981

[Chromosome anomalies and their consequences for deviant behavior (author's transl)].

Chromosome anomalies are always accompanied by more or less serious behavior disorders. Yet deviant behavior in autosomal chromosome aberrations, especially the Down syndrome, on account of their severity and considerable reduction of intelligence of those affected, are far less important to the public than the gonosomal aberrations: the Klinefelter syndrome (XXY), the XYY syndrome, gonadal dysgenesis (Turner's syndrome, XO).

Antisocial Personality Disorder↗
PubMed1980

[Genetic aspects of risk factors with particular reference to ischemic heart disease (author's transl)].

Ischemic heart diseases are of a polyetiological nature. Primarily they appear to be consequences of "psychosocial factors". Genetic influences are also of importance. Epidemiological studies and investigations of twins, families and blood groups support this. Members of blood group A carry a disease risk 18% higher than blood group 0. The extent of the genetic partial factors cannot be estimated at present. In addition atherosclerosis is presumably genetically heterogenous. This communal cause should be taken into consideration for prevention in the sense of "genetic individual prognosis and prophylaxis".

ABO Blood-Group System↗