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Biomedical subjects

G Just

Publications and source records attributed to G Just.

48 records · Page 3Linked to original sources
PubMedDate not supplied

Assisted living: challenges for nursing practice.

There can be no doubt about that, as the elderly population increases, there is a need to provide alternative models of housing and health care. The elderly have become a vocal group, defining their needs and demanding their rights. New models of care, such as assisted living, allow elders to age in place, and nurses are called upon to adapt to the challenges of practice. We need to be responsive to the changing needs of the elderly population, to alter the directive focus of our practice to a more assistive model, and we must look at our practice itself to determine what changes need to take place to promote aging with maximum independence.

Activities of Daily Living↗
PubMedDate not supplied

Chimeric RNA with modified backbones: alternating methylene(methylimino) linked phosphodiester backbone oligonucleotides with 2'-OH and 2'-OMe groups.

Synthesis of a novel ribo-MMI dimer with 2'-OH and 2'-OMe in 5'- and 3'-nucleosides, respectively is presented. The synthesis was accomplished by reductive coupling of 3'-deoxy-3'-C-formyluridine and 2'-O-methyl-5'-O-methylaminouridine via a thioacetal as the key intermediate for the top part of the dimer. Incorporation of ribo-MMI dimers into oligonucleotides increased binding affinity for target RNA.

Oligonucleotides↗